Results 1 to 10 of about 220,080 (264)
Frontiers in Molecular Neuroscience, 2023 Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circuitry ...
Julien Gasser +7 more
doaj +1 more source
Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke. [PDF]
, 2023 Ischemic stroke is a major global health issue and characterized by acute vascular dysfunction and subsequent neuroinflammation. However, the relationship between these processes remains elusive.
Roth, Stefan +23 more
core +1 more source
Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway [PDF]
, 2022 Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia and astrocytes, play key roles in the activation and maintenance of inflammatory responses in the ...
Gonçalves, Carlos Alberto +13 more
core +2 more sources
Frontiers in Immunology, 2023 NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death.
Marie-Laure Clénet +7 more
doaj +1 more source
Brain, Behavior, & Immunity - Health, 2020 Early life adversities during childhood (such as maltreatment, abuse, neglect, or parental deprivation) may increase the vulnerability to cognitive disturbances and emotional disorders in both, adolescence and adulthood.
S. Bachiller +4 more
doaj +1 more source
Scientific Reports, 2021 Microglial cells are affected in Alzheimer’s disease (AD) and interact with amyloid-beta (Aβ) plaques. Apart from memory loss, depression is common in patients with AD.
Martina Svensson +6 more
doaj +1 more source
Journal of Neuroinflammation, 2023 Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific targeting of both T and B cell effector functions ...
Mathangi Janakiraman +4 more
doaj +1 more source
Scientific Reports, 2021 The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hhet TREM2 ...
Katharina Cosker +7 more
doaj +1 more source
PET Radioligands for in Vivo Visualization of Neuroinflammation. [PDF]
, 2014 Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders. The microglia which make up the innate immune system of the central nervous system are key cellular mediators of ...
Ory, Dieter +4 more
core +1 more source
Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response
Frontiers in Cellular Neuroscience, 2018 Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization,
Sara Bachiller +6 more
doaj +1 more source