Results 21 to 30 of about 159,456 (265)
Cells, 2021 In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in ...
Alejandro Torrillas de la Cal +7 more
doaj +1 more source
Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology
Journal of Neuroinflammation, 2023 Background Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune ...
Grégoire Stym-Popper +8 more
doaj +1 more source
PPARs in Neuroinflammation [PDF]
PPAR Research, 2008 Welcome to this special issue of PPAR Research dedicated to “PPARs in Neuroinflammation.” The central nervous system (CNS) was once thought to be an immune-privileged site void of significant inflammation. However, it is now clear that activated peripheral immune cells are capable or entering and functioning within the CNS. In addition, resident immune
Paul D. Drew, Michael K. Racke
openaire +3 more sources
Molecular Neurodegeneration, 2022 ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's ...
Rosalía Fernández-Calle +11 more
doaj +1 more source
Neuroinflammation in Friedreich’s Ataxia
International Journal of Molecular Sciences, 2022 Friedreich’s ataxia (FRDA) is a rare genetic disorder caused by mutations in the gene frataxin, encoding for a mitochondrial protein involved in iron handling and in the biogenesis of iron−sulphur clusters, and leading to progressive nervous system damage.
Apolloni, Savina +2 more
openaire +3 more sources
Molecules, 2021 Imidazo[1,2-b]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity.
Rakesh Kumar Sharma +7 more
doaj +1 more source
Estrogens, Neuroinflammation, and Neurodegeneration [PDF]
Endocrine Reviews, 2016 Inflammatory activation of microglia is a hallmark of several disorders of the central nervous system. In addition to protecting the brain against inflammatory insults, microglia are neuroprotective and play a significant role in maintaining neuronal connectivity, but the prolongation of an inflammatory status may limit the beneficial functions of ...
VILLA, ALESSANDRO MARIA GIOVANNI +3 more
openaire +3 more sources
Neuroinflammation in Alzheimer's disease [PDF]
The Lancet Neurology, 2015 Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release ...
Heneka, Michael T +36 more
openaire +14 more sources
NeuroImage: Clinical, 2016 Spinal cord (SC) atrophy, i.e. a reduction in the SC cross-sectional area (CSA) over time, can be measured by means of image segmentation using magnetic resonance imaging (MRI).
Marios C. Yiannakas +11 more
doaj +1 more source
Journal of Neuroinflammation, 2022 Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing ...
S. Bachiller +12 more
doaj +1 more source