Results 21 to 30 of about 220,080 (264)

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats [PDF]

, 2013
Purpose: Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia.
Banister, S D, Julyan, P, Rothwell, N J, Alison Smigova (281869), Galea, James, Cawthorne, Christopher, Wilkinson, S M, Christian Prenant (281864), Herholz, K; id_orcid, Renaud Maroy (281866), Herholz, Karl, Michael Kassiou, Wilkinson, Shane M, Peter Julyan (281871), Maroy, Renaud, Gavin Brown, Samuel D Banister, Boutin, Hervé, Banister, Samuel D, Greenhalgh, A D, Wilkinson, Shane M., Karl Herholz, Prenant, Christian, Karl Herholz (281875), Boutin, H, Hervé Boutin (281863), Michael Kassiou (281876), Hervé Boutin, Christopher Cawthorne, Rothwell, Nancy J., Brown, G, Nancy J. Rothwell (281877), Banister, Samuel D., Kassiou, M, James Galea (281867), Alison Smigova, Julyan, Peter, Brown, Gavin, Smigova, Alison, Smigova, A, Andrew D. Greenhalgh (281868), Gavin Brown (281874), James Galea, Kassiou, Michael, Rothwell, Nancy J, Christian Prenant, Samuel D. Banister (281873), Christopher Cawthorne (281870), Renaud Maroy, Maroy, R, Peter Julyan, Prenant, C, Greenhalgh, Andrew D., Greenhalgh, Andrew D, Shane M. Wilkinson (281872), Boutin, Hervé; id_orcid, Andrew D Greenhalgh, Cawthorne, C, Nancy J Rothwell, Galea, J, Shane M Wilkinson, Wilkinson Shane M., Rothwell, N, Banister Samuel D., Maroy Renaud, Greenhalgh, A, Banister, S, Prenant Christian, Herholz, K, Greenhalgh Andrew D., Herholz Karl, Julyan Peter, Julyan, Peter J, Galea James, Boutin Hervé, Smigova Alison, Wilkinson, S, Brown Gavin, Cawthorne Christopher, Kassiou Michael, Rothwell Nancy J.   +80 more
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RelB and Neuroinflammation

, 2021
Neuroinflammation within the central nervous system involves multiple cell types that coordinate their responses by secreting and responding to a plethora of inflammatory mediators.
Alexandra Gonsiewski, Karli Mockenhaupt, Tomasz Kordula   +2 more
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Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation

, 2019
Publisher Copyright: © 2019 The Author(s).Background: Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease (PD) and sepsis. Despite microglial cells being
Elgueta, Daniela, Bono, María Rosa, Universidad San Sebastián, Montoya, Andro, Matus, Soledad, Campos, Javier, Falcón, Paulina, Pacheco, Rodrigo, Chovar, Ornella, Alfaro, Iván   +9 more
core   +2 more sources

Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology

Journal of Neuroinflammation, 2023
Background Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune ...
Grégoire Stym-Popper, Karen Matta, Thomas Chaigneau, Roshan Rupra, Alexandros Demetriou, Stéphane Fouquet, Cira Dansokho, Cécile Toly-Ndour, Guillaume Dorothée   +8 more
doaj   +1 more source

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Molecular Neurodegeneration, 2022
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's ...
Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg   +11 more
doaj   +1 more source

Neuroinflammation in Prion Disease

, 2021
Neuroinflammation, typically manifest as microglial activation and astrogliosis accompanied by transcriptomic alterations, represents a common hallmark of various neurodegenerative conditions including prion diseases.
Meiling Chen, Bei Li, Caihong Zhu
core   +1 more source

Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32

Molecules, 2021
Imidazo[1,2-b]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity.
Rakesh Kumar Sharma, Manisha Singh, Khagendra Ghimeray, Pinky Juneja, Gagan Dev, Sridhar Pulavarthi, Sabbasani Rajasekhara Reddy, Ravi Shankar Akundi   +7 more
doaj   +1 more source

Using antifibrinolytics to tackle neuroinflammation [PDF]

, 2020
Plasmin is generally known as a promotor of inflammation. Recent advancement suggests that it has a complex role as immunity modulator. Pharmacological inhibition of plasmin production and activity has been proven to improve neurological outcomes in ...
Atsev, Stanimir, Tomov, Nikola Stefanov, Tomov N, Atsev S   +3 more
core   +2 more sources

Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis

NeuroImage: Clinical, 2016
Spinal cord (SC) atrophy, i.e. a reduction in the SC cross-sectional area (CSA) over time, can be measured by means of image segmentation using magnetic resonance imaging (MRI).
Marios C. Yiannakas, Ahmed M. Mustafa, Benjamin De Leener, Hugh Kearney, Carmen Tur, Daniel R. Altmann, Floriana De Angelis, Domenico Plantone, Olga Ciccarelli, David H. Miller, Julien Cohen-Adad, Claudia A.M. Gandini Wheeler-Kingshott   +11 more
doaj   +1 more source

Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner

Journal of Neuroinflammation, 2022
Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing ...
S. Bachiller, I. Hidalgo, M. G. Garcia, A. Boza-Serrano, A. Paulus, Q. Denis, C. Haikal, O. Manouchehrian, O. Klementieva, J. Y. Li, C. J. Pronk, G. K. Gouras, T. Deierborg   +12 more
doaj   +1 more source