Results 41 to 50 of about 211,053 (311)

Diesel exhaust impairs TREM2 to dysregulate neuroinflammation

, 2020
BACKGROUND: Air pollution has been linked to neurodegenerative diseases, including Alzheimer's disease (AD), and the underlying neuroimmune mechanisms remain poorly understood.
Messenger, Evan J., Royland, Joyce L., Greve, Hendrik J., Mumaw, Christen L., Block, Michelle L., Kodavanti, Prasada R. S., Kodavanti, Urmila P.   +6 more
core   +1 more source

Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury

Scientific Reports, 2023
Emerging evidences suggest that immune receptors participate in diverse microglial and macrophage functions by regulating their immunometabolism, inflammatory phenotype and phagocytosis. CD300f, a TREM2-like lipid sensing immune receptor, that integrates
Daniela Alí-Ruiz, Nathalia Vitureira, Hugo Peluffo   +2 more
doaj   +1 more source

Perivascular spaces and their role in neuroinflammation. [PDF]

, 2022
It is uncontested that perivascular spaces play critical roles in maintaining homeostasis and priming neuroinflammation. However, despite more than a century of intense research on perivascular spaces, many open questions remain about the anatomical ...
Proulx, Steven T, Okar, Serhat V, Reich, Daniel S, Engelhardt, Britta, Lassmann, Hans, Ineichen, Benjamin V   +5 more
core   +1 more source

Exosomes: unconventional players in spinal cord neuroinflammation [PDF]

, 2022
Neuroinflammation is a common underlying event in all central nervous system diseases, essentially based on altered communication patterns between resident cells (neurons and glia), which finally leads to detrimental functional alteration and potentially
Memo, Christian
core  

Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration [PDF]

, 2023
Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability.
Jialiu Zeng, Kah Leong Lim, Cristian Silva, Reynolds, Richard, Lim, Kah Leong, Wong, Jia Hui, Barron, Anna M, Richard Reynolds, Zeng, Jialiu, Lo, Chih Hung, Silva, Cristian, Joseph D. Quick, Anna M. Barron, Jia Hui Wong, Quick, Joseph D, Chih Hung Lo   +15 more
core   +1 more source

Experimental autoimmune encephalomyelitis from a tissue energy perspective [version 1; referees: 2 approved]

F1000Research, 2017
Increasing evidence suggests a key role for tissue energy failure in the pathophysiology of multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE), a commonly used model of MS, have been instrumental in illuminating the ...
Roshni A Desai, Kenneth J Smith
doaj   +1 more source

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice [PDF]

, 2020
Background: Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes.
Liu, Y, Wong, GTC, Yan, T, Chu, JMT, Zhang, Y, Chen, Y, Chang, RCC   +6 more
core   +1 more source

Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease. [PDF]

, 2012
In Alzheimer’s disease (AD), persistent microglial activation as sign of chronic neuroinflammation contributes to disease progression. Our study aimed to in vivo visualize and quantify microglial activation in 13- to 15-month-old AD mice using [11C]-(R ...
Viel, Thomas, Neumaier, Bernd, Höhn, Mathias, Rapic, Sara, Van der Linden, Annemie, Höhn, M., van der Linden, A., Jacobs, Andreas H, Kummer, Markus P., Jacobs, Andreas H., Hoehn, Mathias, Vollmar, Stefan, Heneka, M., Rapic, S., Backes, H., Jacobs, A., HENEKA, Michael, Vollmar, S., Neumaier, B., Kummer, M., Monfared, P., Backes, Heiko, Kummer, Markus P, Viel, T., Heneka, Michael T., Heneka, Michael T, Monfared, Parisa   +26 more
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Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration

Clinical and Developmental Immunology, 2008
Endothelial cells that functionally express blood brain barrier (BBB) properties are useful surrogates for studying leukocyte-endothelial cell interactions at the BBB.
Shumei Man, Eroboghene E. Ubogu, Katherine A. Williams, Barbara Tucky, Melissa K. Callahan, Richard M. Ransohoff   +5 more
doaj   +1 more source

Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia

Neurobiology of Stress, 2016
Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery.
Martina Svensson, Philip Rosvall, Antonio Boza-Serrano, Emelie Andersson, Jan Lexell, Tomas Deierborg   +5 more
doaj   +1 more source