Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer's mouse model [PDF]
, 2020 Background Diabetes is a risk factor for developing Alzheimer's disease (AD); however, the mechanism by which diabetes can promote AD pathology remains unknown.
Fernández Ponce, Cecilia Matilde +7 more
core +3 more sources
Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI)
Cells, 2022 STING-associated vasculopathy with onset in infancy (SAVI) is a type I interferonopathy caused by gain-of-function mutations in STING1 encoding stimulator of interferon genes (STING) protein.
Clémence David, Marie-Louise Frémond
doaj +1 more source
Brain SciencesRecent research in neuroscience has shown significant advancements in relation to neuroinflammation, especially its role in neurological diseases, including neurodegenerative diseases [...]
Junhui Wang, Jing Sun, Hongxing Wang
openaire +3 more sources
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]
, 2016 BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki +9 more
core +2 more sources
Disseminated Intracranial and Spinal Neurenteric Cysts: A Case Report and Literature Review
Case Reports in Neurological MedicineNeurenteric cysts (NECs) are rare congenital, benign lesions of the central nervous system (CNS), predominantly located within the spinal cord. However, they may also occur less frequently within the brainstem, fourth ventricle, or cerebellopontine angle
Jan Kuschick Feher +6 more
doaj +1 more source
Scientific Reports, 2023 Magnetic resonance neurography (MRN) has been used successfully over the years to investigate the peripheral nervous system (PNS) because it allows early detection and precise localisation of neural tissue damage.
Ratthaporn Boonsuth +7 more
doaj +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Real‐World Comparison of High‐Efficacy Versus Non‐High‐Efficacy Therapies in Multiple Sclerosis
Annals of Clinical and Translational NeurologyObjective The choice of the first disease modifying treatment (DMT) in multiple sclerosis (MS) is a topic of great interest, and whether high‐efficacy DMTs should be the first choice remains debated. We compared treatment outcomes (no evidence of disease
Sarmad Al‐Araji +9 more
doaj +1 more source
Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
Annals of Clinical and Translational Neurology, 2021 We present a case of atypical recurrent optic neuritis. A man in his 50s presented with right optic neuritis and profound visual loss, associated with elevated inflammatory markers. Lymph‐node biopsy was consistent with sarcoidosis.
Michael A. Foster +4 more
doaj +1 more source