Results 71 to 80 of about 220,080 (264)

The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia

, 2018
microglia; MMP; neuroinflammation; neuroprotection; TIMP-
김희선, 이은정
core   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Magnetisation transfer ratio combined with magnetic resonance neurography is feasible in the proximal lumbar plexus using healthy volunteers at 3T

Scientific Reports, 2020
Magnetic resonance neurography (MRN) has been used extensively to study pathological conditions affecting the peripheral nervous system (PNS).
Marios C. Yiannakas, Torben Schneider, Masami Yoneyama, Innocent Aforlabi-Logoh, Ferran Prados, Olga Ciccarelli, Claudia A. M. Wheeler-Kingshott   +6 more
doaj   +1 more source

Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway [PDF]

, 2020
Background: Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission.
Felipo, Vicente, Mora-Navarro, Eloy, Juciute, Nora, Cabrera-Pastor, Andrea, Arenas Ortiz, Yaiza María, Vicente Felipo, Andrea Cabrera-Pastor, Yaiza M. Arenas, Eloy Mora-Navarro, Nora Juciute   +9 more
core   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Neuroinflammation: Molecular Mechanisms and Therapeutic Perspectives

, 2022
Background: Neuroinflammation is a key component in the etiopathogenesis of neurological diseases and brain aging. This process involves the brain immune system that modulates synaptic functions and protects neurons from infection or damage.
Santoro A., Mele E., Operto F. F., Pastorino G. M. G., Meccariello R., Viggiano A., Marino M.   +6 more
core   +2 more sources

KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by β-amyloid (βA) accumulation, neuroinflammation, excessive synaptic pruning, and cognitive decline. Despite extensive research, effective treatments remain elusive.
Almazán, Jorge L., Valle-García, David, Arcos-Encarnación, Bolivar, Almazán, Jorge Luis, Hovan, Ladislav, Gil, Jeovanis, Encarnación-Guevara, Sergio, Cortes-Flores, Eladio, Pérez-Martínez, Leonor, Camacho-Concha, Nohemi, Pedraza-Alva, Gustavo, Meza-Sosa, Karla F., Kuijjer, Marieke L., Díaz de León-Guerrero, Sol, González-Arenas, Aliesha, Kuijjer, Marieke Lydia, Barón-Mendoza, Isabel, Barón-Mendoza, Isabel,, Valle-García, David,, Pérez-Martínez, Leonor,, Arcos-Encarnación, Bolivar,, Encarnación-Guevara, Sergio,, Meza-Sosa, Karla F.,, Cortes-Flores, Eladio,, Hovan, Ladislav,, Gil, Jeovanis,, Kuijjer, Marieke Lydia,, González-Arenas, Aliesha,, Lund University.   +28 more
core   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Ecto-5ʹ-nucleotidase/CD73 reduces COX-2 expression in activated macrophages

Scientific Reports
Extracellular ATP (eATP) is a significant contributor of inflammation through enhanced expression of cyclooxygenase 2 (COX-2). In this study, we explored whether overexpression of ectonucleotidases such as ecto-5’-nucleotidase (NT5E, or CD73 ...
Md. Mostafizur Rahman, Anuvrat Sircar, Simran Lakhina, Prem Kumar, Rinkoo Devi Gupta, Ravi Shankar Akundi   +5 more
doaj   +1 more source

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Cells, 2020
The retina is a highly metabolically active tissue with high-level consumption of nutrients and oxygen. This high metabolic demand requires a properly developed and maintained vascular system.
C. Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósio   +3 more
doaj   +1 more source