Results 91 to 100 of about 264,543 (300)

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Magnetisation transfer ratio combined with magnetic resonance neurography is feasible in the proximal lumbar plexus using healthy volunteers at 3T

Scientific Reports, 2020
Magnetic resonance neurography (MRN) has been used extensively to study pathological conditions affecting the peripheral nervous system (PNS).
Marios C. Yiannakas, Torben Schneider, Masami Yoneyama, Innocent Aforlabi-Logoh, Ferran Prados, Olga Ciccarelli, Claudia A. M. Wheeler-Kingshott   +6 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]

, 2015
Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky, Demon, Dieter, Janssens, Sophie, Lamkanfi, Mohamed, Lornet, Guillaume, Timmerman, Vincent, Ydens, Elke   +6 more
core   +2 more sources

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Ecto-5ʹ-nucleotidase/CD73 reduces COX-2 expression in activated macrophages

Scientific Reports
Extracellular ATP (eATP) is a significant contributor of inflammation through enhanced expression of cyclooxygenase 2 (COX-2). In this study, we explored whether overexpression of ectonucleotidases such as ecto-5’-nucleotidase (NT5E, or CD73 ...
Md. Mostafizur Rahman, Anuvrat Sircar, Simran Lakhina, Prem Kumar, Rinkoo Devi Gupta, Ravi Shankar Akundi   +5 more
doaj   +1 more source

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Cells, 2020
The retina is a highly metabolically active tissue with high-level consumption of nutrients and oxygen. This high metabolic demand requires a properly developed and maintained vascular system.
C. Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósio   +3 more
doaj   +1 more source

The Tale of the Residual Tail: Insights From Continuous Intracranial Monitoring From Post‐Hippocampectomy Dynamics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett, Syeda Amrah Hashmi, Amaan Qureshi, Heather Spader, Shayan Moosa, Ifrah Zawar   +5 more
wiley   +1 more source

Disease-modifying therapies alter gut microbial composition in MS. [PDF]

, 2019
Objective:To determine the effects of the disease-modifying therapies, glatiramer acetate (GA) and dimethyl fumarate (DMF), on the gut microbiota in patients with MS.
Baranzini, Sergio E, Bencosme, Yadira, Brandstadter, Rachel, Casaccia, Patrizia, Cekanaviciute, Egle, Clemente, Jose C, Crabtree-Hartman, Elizabeth, Cree, Bruce AC, Debelius, Justine, Katz Sand, Ilana, Knight, Rob, Ntranos, Achilles, Singh, Sneha, Zhu, Yunjiao   +13 more
core  

Pathophysiologisch-serologische, bildgebende und klinische Charakteristika der Neuromyelitis Optica [PDF]

, 2019
Hintergrund: Neuromyelitis optica-Spektrum-Erkrankungen (NMOSD) stellen eine Gruppe neuroinflammatorischer Erkrankungen dar, die mit dem klinischen Auftreten von Myelitiden und/oder Optikusneuritiden (ON) einhergeht.
Schumacher, Sophie
core   +1 more source