Results 91 to 100 of about 211,053 (311)

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Ecto-5ʹ-nucleotidase/CD73 reduces COX-2 expression in activated macrophages

Scientific Reports
Extracellular ATP (eATP) is a significant contributor of inflammation through enhanced expression of cyclooxygenase 2 (COX-2). In this study, we explored whether overexpression of ectonucleotidases such as ecto-5’-nucleotidase (NT5E, or CD73 ...
Md. Mostafizur Rahman, Anuvrat Sircar, Simran Lakhina, Prem Kumar, Rinkoo Devi Gupta, Ravi Shankar Akundi   +5 more
doaj   +1 more source

Generation of IgG-Fc Glycovariants Using Recombinant Glycosidases and Glycosyltransferases

Bio-Protocol, 2016
The immunoglobulin G (IgG) fragment crystallizable (Fc) domain contains a single, highly conserved asparagine 297 (N297) glycosylation site in the CH2 domain, which is buried within the hydrophobic core of each of the two heavy chains.
Isaak Quast, Michael Maurer, Jan Lünemann   +2 more
doaj   +1 more source

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Cells, 2020
The retina is a highly metabolically active tissue with high-level consumption of nutrients and oxygen. This high metabolic demand requires a properly developed and maintained vascular system.
C. Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósio   +3 more
doaj   +1 more source

The Role of Neuroinflammation in Parkinson's Disease

, 2011
Parkinson's disease (PD) is the second most common neurodegenerative disorder, after Alzheimer's disease (AD). It is characterized by progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) that results in
Chen, Xi, Xi Chen, Malú G. Tansey, Tansey, Malú G   +3 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease [PDF]

, 2012
Background: Neuroinflammation is associated with virtually all major neurodegenerative disorders, including Alzheimer's disease (AD). Although it remains unclear whether neuroinflammation is the driving force behind these disorders, compelling evidence ...
Li, Yazhou, Kathryn A. Frankola, Van Praag, Henriette, Caracciolo, Luca, Susanna Rosi, Greig, Nigel H, Sergio Barlati, Tweedie, David, Weiming Luo, Kelly Fishman, Henriette Van Praag, Barlati, Sergio, Holloway, Harold W, Bosetti, Francesca, Rosi, Susanna, Ray, Balmiki, Yazhou Li, Luca Caracciolo, Ferguson, Ryan A, Fishman, Kelly, Luo, Weiming, Ryan A. Ferguson, Frankola, Kathryn A, Frankola, Kathryn A., RUSSO, ISABELLA, Nigel H. Greig, Lahiri, Debomoy K., David Tweedie, Balmiki Ray, Greig, Nigel H., Lahiri, Debomoy K, Ferguson, Ryan A., Holloway, Harold W., Francesca Bosetti, Harold W. Holloway, Debomoy K. Lahiri   +35 more
core   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models

, 2020
Background: Neuroinflammation plays a pivotal role in the pathogenesis of Parkinson's disease (PD). Thus, the development of agents that can control neuroinflammation has been suggested as a promising therapeutic strategy for PD.
임예현, 이지희, 박은미, 박진선, 김희선, 최윤희   +5 more
core   +1 more source

Neuroinflammation in Prion Disease

, 2021
Neuroinflammation, typically manifest as microglial activation and astrogliosis accompanied by transcriptomic alterations, represents a common hallmark of various neurodegenerative conditions including prion diseases.
Meiling Chen, Bei Li, Caihong Zhu
core   +1 more source