Results 1 to 10 of about 324,064 (169)
Dissecting the human leptomeninges at single-cell resolution
Nature Communications, 2023 Emerging evidence shows that the meninges conduct essential immune surveillance and immune defense at the brain border, and the dysfunction of meningeal immunity contributes to aging and neurodegeneration.
Nicola A. Kearns +8 more
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npj Digital Medicine, 2023 Hand drawing, which requires multiple neural systems for planning and controlling sequential movements, is a useful cognitive test for older adults.
Shinya Tasaki +6 more
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Acta Neuropathologica Communications, 2021 Lewy bodies (LBs) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older persons and associated with cognitive impairment.
Sonal Agrawal +6 more
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Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks
Nature Communications, 2022 Protein changes in a brain with Alzheimer’s are not often accompanied by transcriptional differences. Here, using a deep neural network that predicts protein abundance from mRNA expression, the authors track the early protein changes in Alzheimer’s ...
Shinya Tasaki +8 more
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Brain Sciences, 2021 The aim of the study was to examine potential cognitive, mood (depression and anxiety) and behavioral changes that may be related to the quarantine and the lockdown applied during the COVID-19 pandemic in Greek older adults with mild cognitive impairment
Marianna Tsatali +20 more
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Alzheimer’s Research & Therapy, 2022 Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) and plasma from ...
Eric B. Dammer +7 more
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Cortical proteins may provide motor resilience in older adults
Scientific Reports, 2021 Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that ...
Aron S. Buchman +11 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background We previously outlined the importance of considering acculturation within the context of older Latino adults' lived experience (ie, acculturation in context) to better capture contributors to cognitive aging.
Melissa Lamar +8 more
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Differential vulnerability of the dentate gyrus to tauopathies in dementias
Acta Neuropathologica Communications, 2023 The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer’s type due to Alzheimer’s disease (DAT-AD), but less is known about the susceptibility ...
Allegra Kawles +14 more
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Assessment of Screening Approach in Early and Differential Alzheimer’s Disease Diagnosis
Antioxidants, 2021 Background: Alzheimer’s disease (AD) is the leading cause of dementia in the elderly population. Currently, diagnosis is based on invasive and expensive techniques, so there is a growing need to look for other possible tests, as well as carry out ...
Laura Ferré-González +5 more
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