Results 41 to 50 of about 400,612 (318)
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019 Introduction There is a 99.6% failure rate of clinical trials for drugs to treat Alzheimer's disease, likely because Alzheimer's disease (AD) patients cannot be easily identified at early stages. This study investigated machine learning approaches to use
Jack Albright +1 more
doaj +1 more source
, 2016 Additional file 1. The approval Letter from Taipei City Hospital Institutional Review Board.
Shun-Ku Lin +3 more
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Communicability disruption in Alzheimer’s disease connectivity networks
, 2019 In real-world networks, information from source to destination does not only flow along the shortest path connecting them, but can flow along any alternative route.
Eufemia Lella +6 more
core +1 more source
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease [PDF]
, 2023 Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD).
Shin, Monica +11 more
core
Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer’s Disease
Biomedicines, 2022 Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical ...
Md Riad Chowdhury +2 more
doaj +1 more source
, 2016 Additional file 2. The approval Letter from National Institutes of Health.
Shun-Ku Lin +3 more
openaire +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
, 2017 Cost-effectiveness of cerebrospinal biomarkers for Alzheimerâ s diagnosis: supplemental Methods, Results, figures and tables as referenced in the text. (DOCX 91 kb)
Lee, Spencer +3 more
openaire +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source