Results 41 to 50 of about 238,162 (269)

Brain insulin signaling and cerebrovascular disease in human postmortem brain

Acta Neuropathologica Communications, 2021
Insulin is an important hormone for brain function, and alterations in insulin metabolism may be associated with neuropathology. We examined associations of molecular markers of brain insulin signaling with cerebrovascular disease.
Zoe Arvanitakis, Ana W. Capuano, Hoau-Yan Wang, Julie A. Schneider, Alifiya Kapasi, David A. Bennett, Rexford S. Ahima, Steven E. Arnold   +7 more
doaj   +1 more source

Additional file 3: of Older patients are still under-represented in clinical trials of Alzheimerâ s disease

, 2016
List of studies included. (DOCX 34 kb)
Banzi, Rita, Camaioni, Paolo, Tettamanti, Mauro, Bertele’, Vittorio, Lucca, Ugo   +4 more
openaire   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Additional file 1 of A novel approach for multi-SNP GWAS and its application in Alzheimerâ s disease

, 2016
Table 3. Gene pairs with SNP pairs having r 2â Ľ 0.04. (PDF 169 kb)
Bodily, Paul, M. Fujimoto, Page, Justin, Clement, Mark, Ebbert, Mark, Ridge, Perry   +5 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Structural variants linked to Alzheimer’s disease and other common age-related clinical and neuropathologic traits

Genome Medicine
Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder with substantial genetic influence. While genome-wide association studies (GWAS) have identified numerous risk loci for late-onset AD (LOAD), the functional mechanisms underlying
Ricardo A. Vialle, Katia de Paiva Lopes, Yan Li, Bernard Ng, Julie A. Schneider, Aron S. Buchman, Yanling Wang, Jose M. Farfel, Lisa L. Barnes, Aliza P. Wingo, Thomas S. Wingo, Nicholas T. Seyfried, Philip L. De Jager, Chris Gaiteri, Shinya Tasaki, David A. Bennett   +15 more
doaj   +1 more source

Additional file 2: of Older patients are still under-represented in clinical trials of Alzheimerâ s disease

, 2016
list of excluded studies. (DOCX 129 kb)
Banzi, Rita, Camaioni, Paolo, Tettamanti, Mauro, Bertele’, Vittorio, Lucca, Ugo   +4 more
openaire   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

MOESM1 of Histone post-translational modifications in frontal cortex from human donors with Alzheimerâ s disease

, 2015
Additional file 1: Table S1. Donor information.
Anderson, Kyle, Turko, Illarion
openaire   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source