Results 61 to 70 of about 238,162 (269)

Baseline neuroimaging profiles and predictive modelling for early Alzheimer disease prognosis

Scientific Reports
Alzheimer’s disease (AD) presents significant clinical heterogeneity in cognitive decline. Neuroimaging profiles and peripheral biomarkers, such as plasma oxidative stress biomarkers could provide information on AD progression.
Aleix Martí-Navia, Alejandro López-Bellido, Ángel Balaguer, Sara Ballesta-Martínez, Lourdes Álvarez-Sánchez, Mar Peretó, Lorena García-Vallés, Luis Raga, Miguel Baquero, Consuelo Cháfer-Pericás   +9 more
doaj   +1 more source

The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults

Alzheimer’s Research & Therapy, 2023
Background Insulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer’s clinical syndrome in epidemiologic studies but have not been associated with tau tangles in neuropathological research and have been ...
Gilda E. Ennis, Tobey J. Betthauser, Rebecca Langhough Koscik, Nathaniel A. Chin, Bradley T. Christian, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin   +7 more
doaj   +1 more source

Additional file 6: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S6. Negative controls for Fig. 8, panel a (Aβ1â 42 expression). Negative controls are reported in all panels marked with acronyms of secondary antibodies labeled with, respectively, Texas Red (TR) (PDF 455 kb)
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Pathogenic PS1 phosphorylation at Ser367

eLife, 2017
The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ...
Masato Maesako, Jana Horlacher, Katarzyna M Zoltowska, Ksenia V Kastanenka, Eleanna Kara, Sarah Svirsky, Laura J Keller, Xuejing Li, Bradley T Hyman, Brian J Bacskai, Oksana Berezovska   +10 more
doaj   +1 more source

Additional file 5: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S5. Co-localization of CD3 and FoxP3 in the human AD brain. Immunofluorescence in representative samples for both molecules was detected in immune cells in the hippocampus of AD patients, whereas it was absent in the brain of healthy individuals (merge column; DAPIâ =â nuclear staining).
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults

Communications Biology
Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected.
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett   +10 more
doaj   +1 more source

Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits

Scientific Reports, 2023
Differential gene expression (DGE) analysis has been widely employed to identify genes expressed differentially with respect to a trait of interest using RNA sequencing (RNA-Seq) data.
Shizhen Tang, Aron S. Buchman, Yanling Wang, Denis Avey, Jishu Xu, Shinya Tasaki, David A. Bennett, Qi Zheng, Jingjing Yang   +8 more
doaj   +1 more source

Additional file 1: of A phase III randomized trial of gantenerumab in prodromal Alzheimerâ s disease

, 2017
List of institutional review boards and independent ethics committees. (DOCX 20 kb)
Ostrowitzki, Susanne, Lasser, Robert, Dorflinger, Ernest, Scheltens, Philip, Barkhof, Frederik, Nikolcheva, Tania, Ashford, Elizabeth, Retout, Sylvie, Hofmann, Carsten, Delmar, Paul, Klein, Gregory, Andjelkovic, Mirjana, Dubois, Bruno, Boada, Mercè, Blennow, Kaj, Santarelli, Luca, Fontoura, Paulo   +16 more
openaire   +1 more source