Results 61 to 70 of about 647,233 (310)
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Genome MedicineBackground Alzheimer’s disease (AD) is a complex neurodegenerative disorder with substantial genetic influence. While genome-wide association studies (GWAS) have identified numerous risk loci for late-onset AD (LOAD), the functional mechanisms underlying
Ricardo A. Vialle +15 more
doaj +1 more source
Relationship between afternoon napping and cognitive function in the ageing Chinese population
General Psychiatry, 2021 Background Several studies have shown that afternoon napping promotes cognitive function in the elderly; on the other hand, some studies have shown opposite results.
Wei Li +5 more
doaj +1 more source
Storying Alzheimer's Disease in Lisa Genova's Still Alice [PDF]
, 2014 Taking as its starting point the value of literary studies to work on ageing, this paper explores the contribution of literature to the discourse of ageing and illness, focussing on an illness synonymous with ageing in the cultural imagination ...
Falcus, Sarah
core
Predicting Alzheimer's risk: why and how? [PDF]
, 2011 Because the pathologic processes that underlie Alzheimer's disease (AD) appear to start 10 to 20 years before symptoms develop, there is currently intense interest in developing techniques to accurately predict which individuals are most likely to become
Barnes, Deborah E, Lee, Sei J
core +2 more sources
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Scientific Reports, 2023 Differential gene expression (DGE) analysis has been widely employed to identify genes expressed differentially with respect to a trait of interest using RNA sequencing (RNA-Seq) data.
Shizhen Tang +8 more
doaj +1 more source
An Investigation of the Efficacy of Curcumin for Treatment of Alzheimer\u27s Disease [PDF]
, 2016 Curcumin is the primary curcuminoid found in the rhizome of the turmeric plant (Curcuma longa), responsible for the spice’s distinctive yellow color. Research conducted within the past two decades suggests that the compound may be an effective treatment ...
Patel, Parantap
core +1 more source
Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients. [PDF]
, 2018 In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a
Adler, Deb +38 more
core +2 more sources
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source