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Interaction of Proteins Involved in Neuronal Proteinopathies
Life, 2023 Proteinopathy is characterized by the accumulation of aggregates of a specific protein in a target organ, tissue, or cell. The aggregation of the same protein can cause different pathologies as single protein can adopt various amyloidogenic, disease ...
Konstantin Y. Kulichikhin +4 more
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Applied Biochemistry and Biotechnology, 2012 The common view of amyloids and prion proteins is that they are associated with many currently incurable diseases and present a great danger to an organism. This danger comes from the fact that not only prion proteins, but also the infectious form(s) of amyloids, as it has been shown recently, are able to transmit the disease.
Pulawski W +3 more
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AmyloGraph: a comprehensive database of amyloid–amyloid interactions
Nucleic Acids Research, 2022 Abstract Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located in almost 200 publications (selected out of 562 initially considered), obtaining details of 883 ...
Michal Burdukiewicz +14 more
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Functional Mammalian Amyloids and Amyloid-Like Proteins
Life, 2020 Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD ...
Maria S. Rubel +6 more
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eJHaem, 2022 The causal protein of amyloid light‐chain (AL) amyloidosis is a monoclonal immunoglobulin free light chain (mFLC), which must be quantified in the serum for patient diagnosis and monitoring.
Hajer Abroud +18 more
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Biomedical Papers, 2017 Amyloidosis is a heterogeneous group of diseases characterized by the deposition of amyloid. It is caused by extracellular deposition of insoluble fibrils with beta-pleated sheet configuration. The protein misfolding abnormalities result in amyloid fibrils and may manifest as primary, secondary, or familial amyloidosis.
Lucie Karafiatova, Tomas Pika
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Microbial amyloids in neurodegenerative amyloid diseases
The FEBS Journal, 2023 Human‐disease associated amyloidogenic proteins are not unique in their ability to form amyloid fibrillar structures. Numerous microbes produce amyloidogenic proteins that have distinct functions for their physiology in their amyloid form, rather than solely detrimental. Emerging data indicate associations between various microbial organisms, including
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An Efficient Method for Isolation of Plasmid DNA for Transfection of Mammalian Cell Cultures
Methods and Protocols, 2020 In this article, we present several protocols that describe the steps from cloning and obtaining a large amount of pure plasmid DNA to generation of lentiviruses based on these constructs.
Daniel V. Kachkin +3 more
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Clinical Medicine Insights: Cardiology, 2022 Background: Wild-type transthyretin amyloid cardiomyopathy (ATTR-CM) is a frequently under-recognized cause of heart failure (HF) in older patients. To improve identification of patients at risk for the disease, we initiated a pilot program in which 9 ...
Joshua D Mitchell +6 more
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Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential [PDF]
Arquivos de Neuro-Psiquiatria, 2020 Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible loss of cognitive function. The presence of senile plaques is one of the pathological markers of the disease and is associated with the ...
Júlia Canto e SOUSA +2 more
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