Results 21 to 30 of about 405,002 (265)

Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth

Experimental Hematology & Oncology, 2018
Background The monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protein on myeloma and also on CD34+ hematopoietic progenitor cells.
Xun Ma, Sandy W. Wong, Ping Zhou, Chakra P. Chaulagain, Parul Doshi, Andreas K. Klein, Kellie Sprague, Adin Kugelmass, Denis Toskic, Melissa Warner, Kenneth B. Miller, Lisa Lee, Cindy Varga, Raymond L. Comenzo   +13 more
doaj   +1 more source

Prevalence and determinants of iron deficiency in cardiac amyloidosis

ESC Heart Failure, 2022
Aims Iron deficiency (ID) is common in patient with chronic heart failure (HF) and has been widely studied. In contrast, data concerning ID in cardiac amyloidosis (CA) are limited.
Antoine Jobbé‐Duval, Mélanie Bézard, Stéphane Moutereau, Mounira Kharoubi, Silvia Oghina, Amira Zaroui, Arnault Galat, Coraline Chalard, Elisabeth Hugon‐Vallet, Francois Lemonnier, Damien Eyharts, Elsa Poulot, Pascale Fanen, Benoit Funalot, Valérie Molinier‐Frenkel, Vincent Audard, Luc Hittinger, Marc Antoine Delbarre, Emmanuel Teiger, Thibaud Damy   +19 more
doaj   +1 more source

Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience

Haematologica, 2013
Amyloidosis of the gastrointestinal tract, with biopsy-proven disease, is rare. We reviewed a series of patients who presented with biopsy-proven gastrointestinal amyloidosis and report their clinical characteristics, treatments, and survival.
Andrew J. Cowan, Martha Skinner, David C. Seldin, John L. Berk, David R. Lichtenstein, Carl J. O'Hara, Gheorghe Doros, Vaishali Sanchorawala   +7 more
doaj   +1 more source

A multidisciplinary case report of multiple myeloma with renal and cardiac involvement: a look beyond amyloidosis

BMC Nephrology, 2022
Background Multiple myeloma (MM) is a malignant neoplasm associated with kidney involvement in nearly half of the patients. Cast nephropathy, monoclonal immunoglobulin deposition disease (MIDD), and light chain (AL) amyloidosis are the most common ...
Samantha Innocenti, Beatrice Bacchi, Marco Allinovi, Federico Perfetto, Elisabetta Antonioli, Niccolo’ Marchionni, Carlo Di Mario, Leonardo Caroti, Francesco Cappelli, Pierluigi Stefàno   +9 more
doaj   +1 more source

Melphalan, lenalidomide and dexamethasone for the treatment of immunoglobulin light chain amyloidosis: results of a phase II trial

Haematologica, 2013
We report results of a phase II trial of combination of melphalan, lenalidomide, and dexamethasone for the treatment of immunoglobulin light chain (AL) amyloidosis.
Vaishali Sanchorawala, Jaymin M. Patel, J. Mark Sloan, Anthony C. Shelton, Jerome B. Zeldis, David C. Seldin   +5 more
doaj   +1 more source

Amyloid goiter

International Journal of Surgery, 2008
Amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. Amyloidosis is a rare occurrence in thyroid gland.A systematic review of the published data on amyloid goiter was carried out by searching Medline and other online databases (such as Scopus and Endnote) for the period from 1951 to ...
VILLA F, DIONIGI, GIANLORENZO, TANDA, MARIA LAURA PIERA, ROVERA, FRANCESCA ANGELA, BONI, LUIGI   +4 more
openaire   +4 more sources

The Role of Amyloidogenesis in Cancer Development: An Investigation of Transcription Factors

Proceedings
Cancer remains the leading cause of death due to a wide range of molecular mechanisms [...]
Marina V. Ryabinina, Andrew A. Zelinsky, Aleksandr A. Rubel   +2 more
doaj   +1 more source

Beyond Amyloid Fibers: Accumulation, Biological Relevance, and Regulation of Higher-Order Prion Architectures

Viruses, 2022
The formation of amyloid fibers is associated with a diverse range of disease and phenotypic states. These amyloid fibers often assemble into multi-protofibril, high-order architectures in vivo and in vitro.
Wesley R. Naeimi, Tricia R. Serio
doaj   +1 more source

Bacterial Amyloids [PDF]

, 2012
Many bacteria can assemble functional amyloid fibers on their cell surface. The majority of bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface or with another cell. Bacterial amyloids, like all functional amyloids, share structural and biochemical properties with disease-associated eukaryotic ...
Yizhou, Zhou, Luz P, Blanco, Daniel R, Smith, Matthew R, Chapman   +3 more
openaire   +2 more sources

Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells

Biochemistry and Biophysics Reports
Background: Light chain research is hampered by lack of mammalian cell lines producing human light chains (FLC). Therefore, we used heterohybridoma (HH) technology to produce clones making FLC thereby providing tools to study light chain behavior ...
P. Zhou, X. Ma, S. Scalia, D. Toskic, X. Wu, T. Fogaren, Nancy Coady Lyons, Luis del Pozo-Yauner, R.L. Comenzo   +8 more
doaj   +1 more source