Results 41 to 50 of about 560,049 (292)
Exploring Biomolecular Self-Assembly with Far-Infrared Radiation
Biomolecules, 2022 Physical engineering technology using far-infrared radiation has been gathering attention in chemical, biological, and material research fields. In particular, the high-power radiation at the terahertz region can give remarkable effects on biological ...
Takayasu Kawasaki +4 more
doaj +1 more source
The amyloid precursor protein: beyond amyloid.
Molecular neurodegeneration, 2006 The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Zheng H., Koo E.H.
openaire +3 more sources
Yeast Approach in Amyloidogenic Proteins Study
ProceedingsSelf-reproducing protein aggregates of a fibrillar nature (amyloids) are associated with a number of animal and human diseases [...]
Andrew A. Zelinsky +3 more
doaj +1 more source
Night‐to‐night variability in sleep and amyloid beta burden in normal aging
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023 INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants
Aurore Jouvencel +10 more
doaj +1 more source
Implication of tau propagation on neurodegeneration in Alzheimer’s disease
Frontiers in Neuroscience, 2023 Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression of Alzheimer’s disease (AD). Although it is not well-established what drives or attenuates tau spreading, new studies on human brain using
Daniel Lamontagne-Kam +4 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]
, 2006 Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Patterns of amyloid accumulation in amyloid-negative cases
Neurobiology of Aging, 2022 Introduction: Amyloid staging models showed that regional abnormality occurs before global positivity. Several studies assumed that the trajectory of amyloid spread is homogeneous, but clinical evidence suggest that it is highly heterogeneous. We tested whether different Aβ-patterns exist by applying a clustering on negative scans and investigating ...
Alchera, Nicola +10 more
openaire +4 more sources