Results 41 to 50 of about 652,108 (304)
The Development of an Early Diagnostic Method for Alzheimer’s Disease
ProceedingsAlzheimer’s disease (AD) is the most common form of dementia, characterized by neuronal degeneration and death [...]
Yulia K. Styufliaeva +3 more
doaj +1 more source
Night‐to‐night variability in sleep and amyloid beta burden in normal aging
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023 INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants
Aurore Jouvencel +10 more
doaj +1 more source
Implication of tau propagation on neurodegeneration in Alzheimer’s disease
Frontiers in Neuroscience, 2023 Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression of Alzheimer’s disease (AD). Although it is not well-established what drives or attenuates tau spreading, new studies on human brain using
Daniel Lamontagne-Kam +4 more
doaj +1 more source
Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]
, 2018 IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat +7 more
core +1 more source
Yeast Approach in Amyloidogenic Proteins Study
ProceedingsSelf-reproducing protein aggregates of a fibrillar nature (amyloids) are associated with a number of animal and human diseases [...]
Andrew A. Zelinsky +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2018 Many bacteria can assemble functional amyloid fibers on their cell surface. Most bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface or with other cells. Bacterial amyloids, like all functional amyloids, share structural and biochemical properties with disease-associated eukaryotic amyloids.
Margery L, Evans +3 more
openaire +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers. [PDF]
, 2020 Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene.
de Oliveira, Guilherme AP +8 more
core +1 more source
Molecular Dynamics Studies on 3D Structures of the Hydrophobic Region PrP(109-136) [PDF]
, 2013 Prion diseases caused by the conversion from a soluble normal cellular prion protein into insoluble abnormally folded infectious prions, are invariably fatal and highly infectious degenerative diseases that affect a wide variety of mammalian species. The
Zhang, Jiapu, Zhang, Yuanli
core +4 more sources