Results 51 to 60 of about 547,277 (291)

Functional Amyloids [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are usually associated with disease including Alzheimer's. However, amyloid has many useful features.
Otzen, Daniel, Riek, Roland
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Analysis of the Amyloid-like Properties of COL2A1 Protein

Proceedings
Amyloids are proteins which exist in the form of insoluble aggregates and possess a characteristic cross-beta structure [...]
Aleksandra Brukkel, Andrew A. Zelinsky, Marina V. Ryabinina, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults

Frontiers in Aging, 2021
An enriched environment is effective in stimulating learning and memory in animal models as well as in humans. Environmental enrichment increases brain-derived neurotrophic factor (BDNF) in aged rats and reduces levels of Alzheimer-related proteins in ...
Allison N. Grossberg, Brianne M. Bettcher, Kim A. Gorgens, Aurélie Ledreux   +3 more
doaj   +1 more source

Patterns of amyloid accumulation in amyloid-negative cases

Neurobiology of Aging, 2022
Amyloid staging models showed that regional abnormality occurs before global positivity. Several studies assumed that the trajectory of amyloid spread is homogeneous, but clinical evidence suggests that it is highly heterogeneous. We tested whether different amyloid-β (Aβ) patterns exist by applying clustering on negative scans and investigating their ...
Alchera, Nicola, Garibotto, Valentina, Tomczyk, Szymon, Treyer, Valerie, Hock, Christoph, Gietl, Anton F, Lövblad, Karl-Olof, Scheffler, Max, Chincarini, Andrea, Frisoni, Giovanni B, Ribaldi, Federica   +10 more
openaire   +4 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Prevalence, Characteristics, and Impact on Prognosis of Aortic Stenosis in Patients With Cardiac Amyloidosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac amyloidosis (CA) is frequently found in older patients with aortic stenosis (AS). However, the prevalence of AS among patients with CA is unknown.
Mohamed‐Salah Annabi, Rasmus Carter‐Storch, Amira Zaroui, Arnault Galat, Silvia Oghina, Mounira Kharoubi, Mélanie Bezard, Geneviève Derumeaux, Pascale Fanen, François Lemonnier, Elsa Poullot, Emmanuel Itti, Romain Gallet, Emmanuel Teiger, Philippe Pibarot, Thibaud Damy, Marie‐Annick Clavel   +16 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Association of Cerebral Amyloid-beta Aggregation With Cognitive Functioning in Persons Without Dementia [PDF]

, 2018
Importance: Cerebral amyloid-beta aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the ...
Fagan, A.M., Madsen, K., Alcolea, D., Nordberg, A., Spiru, L., Waldemar, G., Alexander, M., Scheltens, P., Rodríguez-Rodríguez, E., Zboch, M., Drzezga, A., Leon, M., Freund-Levi, Y., Herukka, S.K., Sarazin, M., Hellwig, S., Kohler, S., Chetelat, G., Aalten, P., Ivanoiu, A., Johannsen, P., Teunissen, C.E., Forster, S., Novak, G.P., Sanchez-Juan, P., Blennow, K., Verhey, F.R.J., van Buchem, M.A., Chipi, E., Gkatzima, O., Klunk, W.E., Meulenbroek, O., Mroczko, B., Almdahl, I.S., Fladby, T., Stomrud, E., Møllergård, H.M., Struyfs, H., van Waalwijk van Doorn, LJC, Camus, V., Lleo, A., Frederiksen, K.S., van der Flier, W.M., Baldeiras, I., Hildebrandt, H., Froelich, L., Chen, K., Koglin, N., Lisetti, V., Rowe, C.C., Gordon, M.F., Kornhuber, J., Mollergard, H.M., Cavedo, E., Vos, SJB, Newberg, A., Wolk, D.A., Aarsland, D., Hampel, H., Roe, C.M., Vandenberghe, R., Parnetti, L., Peters, O., Verhey, FRJ, Verbeek, M.M., Tijms, B.M., Mintun, M.A., Kramberger, M.G., Rot, U., Zetterberg, H., Villemagne, V.L., Mattsson, N., Morris, J.C., Soininen, H., Laere, K. Van, Brooks, D.J., Ossenkoppele, R., de Mendonça, A., Wallin, Å.K., Grimmer, T., Landau, S.M., Sabri, O., Na, D.L., Rinne, J.O., Rüther, E., Fleisher, A.S., Kapaki, E., Buchem, M.A. van, Meyer, P.T., Hausner, L., Schröder, J., Rabinovici, G.D., Berckel, B.N. van, Frisoni, G.B., Ramakers, I., et al., Ramakers, IHGB, Rami, L., Gabryelewicz, T., Mendonca, A. de, Fortea, J., Flier, W.M. van der, Wallin, A., Jansen, W.J., Visser, P.J., Maier, W., Hansson, O., Cohen, A.D., Lee, D.Y., van Laere, K., van Berckel, BNM, Wiltfang, J., Paraskevas, G.P., Mok, V., Arnold, S.E., Marcusson, J., Tsolaki, M., Oliveira, C. de, Barthel, H., Santana, I., Klimkowicz-Mrowiec, A., Molinuevo, J.L., Engelborghs, S., Resende de Oliveira, C., Nordlund, A., Perera, G., de Leon, M., Popp, J., Jagust, W.J., Seo, S.W.   +128 more
core   +1 more source