Amyloidogenicity assessment of transthyretin gene variants [PDF]
Annals of Clinical and Translational Neurology, 2022 Objective Hereditary transthyretin‐mediated amyloidosis is a treatable condition caused by amyloidogenic variants in the transthyretin‐gene resulting in severe peripheral neuropathy or cardiomyopathy.
Nicolai B. Grether +11 more
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Cardiac Transthyretin Amyloidosis: Hidden in Plain Sight
Case Reports in Medicine, 2021 Amyloidosis is an underappreciated medical condition with symptoms camouflaging as common medical comorbidities leading to its underdiagnosis due to its systemic involvement.
Constantine N. Logothetis +2 more
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Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis [PDF]
Drug Design, Development and Therapy, 2019 Veena Mathew,1 Annabel K Wang1,2 1Department of Neurology, UCI ALS and Neuromuscular Center, University of California, Irvine, Orange, CA, USA; 2Neurology Section, Tibor Rubin VA Medical Center, Long Beach, CA, USA Abstract: Hereditary transthyretin ...
Mathew V, Wang AK
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Transthyretin is a novel innate immune effector against Gram negative bacteria. [PDF]
PLoS PathogensPseudomonas aeruginosa is an opportunistic pathogen that frequently causes severe bloodstream and respiratory infections, yet the interactions between this bacterium and the innate immune system remain poorly investigated.
Tania Bernabé +7 more
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Serum transthyretin combined with first trimester uterine artery doppler ultrasound for preeclampsia prediction in singleton pregnancies: a prospective observational study [PDF]
Scientific ReportsThis study aimed to evaluate the predictive value of serum transthyretin levels in conjunction with uterine artery Doppler ultrasound during the first trimester for predicting preeclampsia.
Siraphat Fungtammasan, Vorapong Phupong
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Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation
Angewandte Chemie - International Edition, 2016 Mutations in the protein transthyretin can cause as well as protect individuals from transthyretin amyloidosis, an incurable fatal inherited disease.
Jin Hae Kim +2 more
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Utility of Genetic Testing in Patients with Transthyretin Amyloid Cardiomyopathy: A Brief Review
Biomedicines, 2023 Transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly diagnosed condition. Although wild-type transthyretin amyloidosis (ATTRwt) is the most common ATTR-CM, hereditary transthyretin amyloidosis (ATTRv) may also occur.
Ana-Maria Merino-Merino +4 more
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Indonesian Biomedical Journal, 2022 BACKGROUND: Transthyretin protein experiences misfolding and aggregation in preeclampsia due to placental ischemia and inflammation. Placental endothelial damage occurring in preeclampsia stimulates the production of larger young platelets in the bone ...
Asri Ragil Kemuning +4 more
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Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease. [PDF]
PLoS ONE, 2015 Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system.
Gonçalo da Costa +10 more
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Biomedicines, 2022 Background: In cardiac amyloidosis, the prevalence of thromboembolic events and atrial fibrillation is higher in transthyretin amyloidosis compared to immunoglobulin light chain amyloidosis.
Mathijs O. Versteylen +3 more
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