Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease. [PDF]
PLoS ONE, 2015 Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system.
Gonçalo da Costa +10 more
doaj +1 more source
Biomedicines, 2022 Background: In cardiac amyloidosis, the prevalence of thromboembolic events and atrial fibrillation is higher in transthyretin amyloidosis compared to immunoglobulin light chain amyloidosis.
Mathijs O. Versteylen +3 more
doaj +1 more source
Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study [PDF]
, 2015 Background Serum retinol concentration determined by high-performance liquid chromatography (HPLC) is recommended by the World Health Organization to assess population vitamin A status.
Inge D Brouwer +18 more
core +2 more sources
Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis [PDF]
The FEBS Journal, 2009 Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins.
openaire +2 more sources
Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome [PDF]
, 2013 Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types.
Banypersad, SM +15 more
core +1 more source
The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig [PDF]
, 2004 Peer ...
Eckersall, P D +71 more
core +1 more source
Transthyretin Amyloidosis and the Kidney [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary The amyloidoses are protein-misfolding disorders associated with progressive organ dysfunction. Immunoglobulin light chain is the most common, amyloid A the longest recognized, and transthyretin-associated amyloidosis (ATTR) the most frequent inherited systemic form.
Luísa, Lobato, Ana, Rocha
openaire +2 more sources
Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein. [PDF]
, 2014 Human transthyretin has an intrinsic tendency to form amyloid fibrils and is heavily implicated in senile systemic amyloidosis. Here, detailed neutron structural studies of perdeuterated transthyretin are described.
core +1 more source
Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Scientific Reports, 2017 In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10−/− mice.
Mancy Tong +7 more
doaj +1 more source