Results 41 to 50 of about 32,046 (240)

Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients

JACC: Basic to Translational Science
Summary: Amyloidogenic transthyretin (ATTR) amyloidosis is a relentlessly progressive disease caused by the misfolding and systemic accumulation of amyloidogenic transthyretin into amyloid fibrils.
Rose Pedretti, BS, Lanie Wang, BS, Anna Yakubovska, MS, Qiongfang S. Zhang, BS, Binh Nguyen, PhD, Justin L. Grodin, MD, Ahmad Masri, MD, Lorena Saelices, PhD   +7 more
doaj   +1 more source

Transthyretin: a multifaceted protein

BioMolecular Concepts, 2014
Abstract Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system.
Vieira Marta, Saraiva Maria João
openaire   +3 more sources

Misdiagnosis of hereditary amyloidosis as AL (Primary) amyloidosis [PDF]

, 2002
Background: Hereditary, autosomal dominant amyloidosis, caused by mutations in the genes encoding transthyretin, fibrinogen A -chain, lysozyme, or apolipoprotein A-I, is thought to be extremely rare and is not routinely included in the differential ...
Booth, D.R., Gilbertson, J.A., Hawkins, P.N., Booth, S.E., Lachmann, H.J., Gillmore, J.D., Bybee, A., Pepys, M.B.   +7 more
core  

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Determinants of transthyretin levels and their association with adverse clinical outcomes among UK Biobank participants

Nature Communications
Transthyretin is a transport protein whose misfolding has been implicated in the development of cardiac amyloidosis. Here, we examine the clinical correlates of transthyretin levels, the differences in transthyretin levels according to the pathogenic ...
Naman S. Shetty, Mokshad Gaonkar, Nirav Patel, Akhil Pampana, Nehal Vekariya, Peng Li, Garima Arora, Pankaj Arora   +7 more
doaj   +1 more source

Amyloid Transthyretin Cardiomyopathy in Elderly Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The prevalence of calcific aortic stenosis and amyloid transthyretin cardiomyopathy (ATTR‐CM) increase with age, and they often coexist. The objective was to determine the prevalence of ATTR‐CM in patients with severe aortic stenosis and ...
Stephan Dobner, Thomas Pilgrim, Daniel Hagemeyer, Dik Heg, Jonas Lanz, Nicole Reusser, Christoph Gräni, Ali Afshar‐Oromieh, Axel Rominger, Bettina Langhammer, David Reineke, Stephan Windecker, Stefan Stortecky   +12 more
doaj   +1 more source

Assessing the Clinical Relevance of Blood Soluble Triggering Receptor Expressed on Myeloid Cells 2 in Neurological Diseases. [PDF]

Eur J Neurosci
Blood sTREM2 is emerging as a potential biomarker of neuroinflammation, yet its biological significance remains poorly understood. In this study, plasma sTREM2 was quantified in 547 individuals across Alzheimer's disease, mild cognitive impairment, multiple sclerosis, ATTR polyneuropathy, asymptomatic ATTR mutation carriers, and healthy controls ...
Agnello L, Gambino CM, Salemi G, Di Stefano V, Piccoli T, Masucci A, Novara S, Ciaccio AM, Del Ben F, Capello D, Ciaccio M.   +10 more
europepmc   +2 more sources

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Transthyretin is a novel innate immune effector against Gram negative bacteria.

PLoS Pathogens
Pseudomonas aeruginosa is an opportunistic pathogen that frequently causes severe bloodstream and respiratory infections, yet the interactions between this bacterium and the innate immune system remain poorly investigated.
Tania Bernabé, María Verd, Guillem Ramis, Alex González-Alsina, Mohammad Qadi, Margalida Mateu-Borrás, Antonio Doménech-Sánchez, Sebastián Albertí   +7 more
doaj   +1 more source

Amyloid polyneuropathy caused by wild‐type transthyretin [PDF]

, 2015
IntroductionAmyloidosis derived from transthyretin (TTR) molecules is typically caused by mutations of the TTR gene.MethodsWe describe an elderly patient with a severe length-dependent polyneuropathy that unexpectedly proved to be caused by wild-type ...
Lam, Lynda, Margeta, Marta, Layzer, Robert   +2 more
core   +1 more source