Results 21 to 30 of about 28,989 (238)

Transthyretin amyloidosis [PDF]

Nursing, 2020
Abstract: Cardiac amyloidosis is a poorly understood cause of heart failure and is often undiagnosed. Recent advances in diagnostic testing and understanding of the disease have enhanced the ability of clinicians to detect this disease and provide patients with appropriate treatment.
Renáta Aiglová, Miloš Táborský, Pavla Flodrová, Alexander Schee   +3 more
openaire   +3 more sources

Pharmacological Interventions for Hereditary Transthyretin-Related Amyloidosis With Polyneuropathy: Systematic Review and Network Meta-Analysis. [PDF]

Eur J Neurol
We conducted a systematic review and network meta‐analysis on pharmacological therapies for ATTRv‐PN. Gene‐silencing therapies were more efficacious than stabilizers for neurological and quality‐of‐life outcomes; there were no differences in serious adverse events.
Duarte GS, Machado TLGN, Rodrigues FB, Conceção I, Pareyson D, da Costa JNMPG, Task Force of the EAN/PNS Joint Guideline for the Management of Neurological Manifestations in Hereditary Transthyretin Amyloidosis.   +6 more
europepmc   +2 more sources

Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein. [PDF]

, 2014
Human transthyretin has an intrinsic tendency to form amyloid fibrils and is heavily implicated in senile systemic amyloidosis. Here, detailed neutron structural studies of perdeuterated transthyretin are described.

core   +1 more source

Transthyretin Amyloidosis and the Kidney [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Summary The amyloidoses are protein-misfolding disorders associated with progressive organ dysfunction. Immunoglobulin light chain is the most common, amyloid A the longest recognized, and transthyretin-associated amyloidosis (ATTR) the most frequent inherited systemic form.
Luísa, Lobato, Ana, Rocha
openaire   +2 more sources

Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia

Scientific Reports, 2017
In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10−/− mice.
Mancy Tong, Shi-bin Cheng, Qi Chen, Joana DeSousa, Peter R. Stone, Joanna L. James, Lawrence W. Chamley, Surendra Sharma   +7 more
doaj   +1 more source

Decreased transthyretin predicts a poor prognosis in primary myelodysplastic syndrome

Frontiers in Nutrition, 2023
BackgroundThis study aims to investigate the prognostic significance of transthyretin in newly diagnosed myelodysplastic syndromes (MDS).MethodsThe clinical, laboratory, and follow-up data of 280 newly diagnosed patients with MDS were collected.
Ying Chen, Ying Chen, Tingting Niu, Tingting Niu, Ting Chen, Ting Chen, Yue Wu, Yue Wu, Duobing Zou, Duobing Zou, Cong Shi, Cong Shi, Ying Wu, Ying Wu, Zhaoyi Zhang, Zhaoyi Zhang, Ningning Wu, Ningning Wu, Yi Zhang, Yi Zhang, Xiao Yan, Xiao Yan, Lixia Sheng, Lixia Sheng, Dingfeng Lv, Guifang Ouyang, Guifang Ouyang, Xueqin Chen, Qitian Mu, Qitian Mu   +29 more
doaj   +1 more source

Eplontersen for Hereditary Transthyretin Amyloidosis With Polyneuropathy: An Exploratory Analysis of Treatment Effect in Male and Female Patients. [PDF]

Muscle Nerve
This exploratory analysis of data from the NEURO‐TTRansform trial evaluated sex‐specific responses in patients with ATTRv‐PN who had received eplontersen in NEURO‐TTRansform versus a historical placebo. Eplontersen can lead to substantial decreases in percentage serum TTR levels, arrest neuropathy impairment, and improve patient quality of life ...
Waddington Cruz M, Berk JL, Parman Y, Gertz M, Khella S, Weiler M, Kwoh TJ, Pola M, Reicher B, Nåtman J, Dasgupta NR, Wixner J.   +11 more
europepmc   +2 more sources

Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction

, 2021
Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of pro-amyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology.
Arun, Raja, Andras, Varadi, Aravindan, Jayaraman, Christopher L., Cioffi, Parthasarathy, Muthuraman, Konstantin, Petrukhin, Srinivasan, Jayakumar, Boglarka, Racz   +7 more
core   +1 more source

Spectrum of transthyretin gene mutations and clinical characteristics of Polish patients with cardiac transthyretin amyloidosis

Cardiology Journal, 2022
BACKGROUND: Transthyretin amyloidosis (ATTR) is a rare, life-threatening systemic disorder. We present first findings on the cardiac hereditary ATTR in Poland.
Monika Gawor, Katarzyna Holcman, Maria Franaszczyk, Marta Lipowska, Piotr Michałek, Anna Teresińska, Zofia T. Bilińska, Paweł Rubiś, Magdalena Kostkiewicz, Wojciech Szot, Piotr Podolec, Jacek Grzybowski   +11 more
doaj   +1 more source

A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

EMBO Molecular Medicine, 2015
The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing
Julien Marcoux, P Patrizia Mangione, Riccardo Porcari, Matteo T Degiacomi, Guglielmo Verona, Graham W Taylor, Sofia Giorgetti, Sara Raimondi, Sarah Sanglier‐Cianférani, Justin LP Benesch, Ciro Cecconi, Mohsin M Naqvi, Julian D Gillmore, Philip N Hawkins, Monica Stoppini, Carol V Robinson, Mark B Pepys, Vittorio Bellotti   +17 more
doaj   +1 more source