Results 21 to 30 of about 10,856 (192)

Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein. [PDF]

, 2014
Human transthyretin has an intrinsic tendency to form amyloid fibrils and is heavily implicated in senile systemic amyloidosis. Here, detailed neutron structural studies of perdeuterated transthyretin are described.

core   +1 more source

Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction [PDF]

, 2021
Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of pro-amyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology.
Arun, Raja, Andras, Varadi, Aravindan, Jayaraman, Christopher L., Cioffi, Parthasarathy, Muthuraman, Konstantin, Petrukhin, Srinivasan, Jayakumar, Boglarka, Racz   +7 more
core   +1 more source

The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker

Frontiers in Physiology, 2019
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body.
Meesha Sharma, Sheeza Khan, Safikur Rahman, Laishram Rajendrakumar Singh   +3 more
doaj   +1 more source

Specific Therapy for Transthyretin Cardiac Amyloidosis: A Systematic Literature Review and Evidence‐Based Recommendations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The emergence of specific therapies for transthyretin cardiac amyloidosis (CA) warrants the need for a systematic review of the literature.
Nuno Marques, Olga Azevedo, Ana Rita Almeida, Dina Bento, Inês Cruz, Emanuel Correia, Carolina Lourenço, Luís Rocha Lopes   +7 more
doaj   +1 more source

Domino living donor liver transplantation of familial amyloid polyneuropathy patient - A case report - [PDF]

Anesthesia and Pain Medicine, 2020
Background Familial amyloid polyneuropathy (FAP) is caused by mutation in a gene transcribing transport protein produced mainly by the liver. Liver transplantation is required to stop FAP progression, but the pathology causes anesthetic management ...
Sungrok Cha, Jiwon Kim, Soo Joo Choi, Gaab Soo Kim   +3 more
doaj   +1 more source

Management of transthyretin amyloidosis

Swiss medical weekly, 2021
Transthyretin amyloidosis (ATTR amyloidosis) is a disease caused by deposition of transthyretin fibrils in organs and tissues, which causes their dysfunction. The clinical heterogeneity of ATTR amyloidosis and the variable presentation of symptoms at early disease stages, historically meant treatment delays. Diagnostic tools and therapy options of ATTR
Condoluci, Adalgisa, Théaudin, Marie, Schwotzer, Rahel, Pazhenkottil, Aju P, Arosio, Paolo, Averaimo, Manuela, Bacher, Ulrike, Bode, Peter, Cavalli, Andrea, Dirnhofer, Stefan, Djerbi, Nadia, Dobner, Stephan, Fehr, Thomas, Garofalo, Maura, Gaspert, Ariana, Gerull, Sabine, Heimgartner, Raphael, Hübers, Annemarie, Jung, Hans H, Kessler, Chiara, Knöpfel, Raphael, Laptseva, Natallia, Magini, Giulia, Manka, Robert, Mazzucchelli, Luca, Meyer, Martin, Mihaylova, Violeta, Monney, Pierre, Mylonas, Alessio, Nkoulou, René, Pabst, Thomas, Pfister, Otmar, Rüfer, Axel, Schmidt, Adrian, Seeger, Harald, Stämpfli, Simon F, Stirnimann, Guido, Suter, Thomas, Treglia, Giorgio, Tzankov, Alexandar, Vetter, Friederike, Zweier, Markus, Flammer, Andreas J, Gerber, Bernhard   +43 more
openaire   +5 more sources

Reply: Bio-Profiling of Transthyretin Amyloid Cardiomyopathy

, 2021
Reply: Bio-Profiling of Transthyretin Amyloid ...
Maurer M. S., Rapezzi C., Sultan M. B., Claudio Rapezzi, Mathew S. Maurer, Marla B. Sultan   +5 more
core   +1 more source

Proteomic analysis of plasma proteins of high-flux haemodialysis and on-line haemodiafiltration patients reveals differences in transthyretin levels related with anaemia

Scientific Reports, 2020
A large proportion of end-stage renal disease (ESRD) patients under long-term haemodialysis, have persistent anaemia and require high doses of recombinant human erythropoietin (rhEPO).
Emma Martínez-Alonso, Paula Alcázar, Emilio Camafeita, Milagros Fernández-Lucas, Gloria Ruíz-Roso, Alberto Alcázar   +5 more
doaj   +1 more source

Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy

Journal of the American College of Cardiology, 2019
Transthyretin (TTR) amyloidosis is an underdiagnosed disease caused by destabilization of TTR due to pathogenic mutations or aging. Both pathogenic and protective mutations illuminate mechanisms of disease and potential interventions. AG10 is a selective, oral TTR stabilizer under development for transthyretin amyloidosis cardiomyopathy (ATTR-CM) that ...
Daniel P, Judge, Stephen B, Heitner, Rodney H, Falk, Mathew S, Maurer, Sanjiv J, Shah, Ronald M, Witteles, Martha, Grogan, Van N, Selby, Daniel, Jacoby, Mazen, Hanna, Jose, Nativi-Nicolau, Jignesh, Patel, Satish, Rao, Uma, Sinha, Cameron W, Turtle, Jonathan C, Fox   +15 more
openaire   +2 more sources

Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient: a case report

Journal of Medical Case Reports, 2017
Background Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy.
Benjamin Terrier, Magali Colombat, Caroline Beugnet, Astrid Quéant, Jonathan London, Jean-Baptiste Daudin, Claire Le Jeunne, Luc Mouthon, Dominique Monnet, Cécile Cauquil, Catherine Lacroix, David Adams, Antoine Brézin, Sophie Valleix   +13 more
doaj   +1 more source