Results 31 to 40 of about 28,989 (238)

Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report

Journal of Medical Case Reports, 2018
Background Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs.
Hiroyuki Yamamoto, Toru Hashimoto, Shunji Kawamura, Michiaki Hiroe, Taro Yamashita, Yukio Ando, Tomoki Yokochi   +6 more
doaj   +1 more source

Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat [PDF]

, 2002
Earlier studies at our laboratory indicated that several hydroxylated polychlorinated biphenyls (OH-PCBs) detected in human blood could specifically inhibit thyroxine (T4) transport by competitive binding to the thyroid hormone transport protein ...
Bergman, A., Berg, J.J.J., van den, van den Berg, J.H.J., Meerts, I.A.T.M., Weijers, B.M., van den Berg, J.J.J., Brouwer, A., Assink, Y., Cenijn, P.H., Berg, J.H.J. van den, Koeman, J.H., Assin, Y.   +11 more
core   +1 more source

Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy

Journal of the American College of Cardiology, 2019
Transthyretin (TTR) amyloidosis is an underdiagnosed disease caused by destabilization of TTR due to pathogenic mutations or aging. Both pathogenic and protective mutations illuminate mechanisms of disease and potential interventions. AG10 is a selective, oral TTR stabilizer under development for transthyretin amyloidosis cardiomyopathy (ATTR-CM) that ...
Daniel P, Judge, Stephen B, Heitner, Rodney H, Falk, Mathew S, Maurer, Sanjiv J, Shah, Ronald M, Witteles, Martha, Grogan, Van N, Selby, Daniel, Jacoby, Mazen, Hanna, Jose, Nativi-Nicolau, Jignesh, Patel, Satish, Rao, Uma, Sinha, Cameron W, Turtle, Jonathan C, Fox   +15 more
openaire   +2 more sources

The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker

Frontiers in Physiology, 2019
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body.
Meesha Sharma, Sheeza Khan, Safikur Rahman, Laishram Rajendrakumar Singh   +3 more
doaj   +1 more source

Transthyretin cardiac amyloidosis

Cardiovascular Research, 2022
AbstractTransthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart failure (HF) and mortality worldwide. Advances in non-invasive diagnosis, coupled with the development of effective treatments, have shifted ATTR-CA from a rare and untreatable disease to a relatively prevalent condition that clinicians should consider on a
Aldostefano Porcari, Marianna Fontana, Julian D Gillmore   +2 more
openaire   +4 more sources

Specific Therapy for Transthyretin Cardiac Amyloidosis: A Systematic Literature Review and Evidence‐Based Recommendations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The emergence of specific therapies for transthyretin cardiac amyloidosis (CA) warrants the need for a systematic review of the literature.
Nuno Marques, Olga Azevedo, Ana Rita Almeida, Dina Bento, Inês Cruz, Emanuel Correia, Carolina Lourenço, Luís Rocha Lopes   +7 more
doaj   +1 more source

Proteomic analysis of plasma proteins of high-flux haemodialysis and on-line haemodiafiltration patients reveals differences in transthyretin levels related with anaemia

Scientific Reports, 2020
A large proportion of end-stage renal disease (ESRD) patients under long-term haemodialysis, have persistent anaemia and require high doses of recombinant human erythropoietin (rhEPO).
Emma Martínez-Alonso, Paula Alcázar, Emilio Camafeita, Milagros Fernández-Lucas, Gloria Ruíz-Roso, Alberto Alcázar   +5 more
doaj   +1 more source

Liver Transplantation for Transthyretin Amyloidosis

, 2009
Liver transplantation has until now proved to be the only treatment available that halts the progression of hereditary transthyretin (TTR) associated amyloidosis.
Ole B. Suhr, Lundgren, E, Ericzon, B-G, Ericzon, Bo-Göran,, Erik Lundgren, Lundgren, Erik,, Bo-Göran Ericzon, Suhr, OB, Suhr, Ole B.,   +8 more
core   +2 more sources

Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient: a case report

Journal of Medical Case Reports, 2017
Background Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy.
Benjamin Terrier, Magali Colombat, Caroline Beugnet, Astrid Quéant, Jonathan London, Jean-Baptiste Daudin, Claire Le Jeunne, Luc Mouthon, Dominique Monnet, Cécile Cauquil, Catherine Lacroix, David Adams, Antoine Brézin, Sophie Valleix   +13 more
doaj   +1 more source

Structural Characterization of Cardiac Ex Vivo Transthyretin Amyloid: Insight into the Transthyretin Misfolding Pathway in Vivo

, 2020
© 2020 American Chemical Society. Structural characterization of misfolded protein aggregates is essential to understanding the molecular mechanism of protein aggregation associated with various protein misfolding disorders.
Lim, Kwang Hun, Gan, Zhehong, Griffin, Robert Guy, Hung, Ivan, Michael, Brian, Kelly, Jeffery W., Dasari, Anvesh K. R., Connors, Lawreen H.   +7 more
core   +2 more sources