Results 31 to 40 of about 32,046 (240)

Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient: a case report

Journal of Medical Case Reports, 2017
Background Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy.
Benjamin Terrier, Magali Colombat, Caroline Beugnet, Astrid Quéant, Jonathan London, Jean-Baptiste Daudin, Claire Le Jeunne, Luc Mouthon, Dominique Monnet, Cécile Cauquil, Catherine Lacroix, David Adams, Antoine Brézin, Sophie Valleix   +13 more
doaj   +1 more source

Structural Characterization of Cardiac Ex Vivo Transthyretin Amyloid: Insight into the Transthyretin Misfolding Pathway in Vivo

, 2020
© 2020 American Chemical Society. Structural characterization of misfolded protein aggregates is essential to understanding the molecular mechanism of protein aggregation associated with various protein misfolding disorders.
Lim, Kwang Hun, Gan, Zhehong, Griffin, Robert Guy, Hung, Ivan, Michael, Brian, Kelly, Jeffery W., Dasari, Anvesh K. R., Connors, Lawreen H.   +7 more
core   +2 more sources

A machine learning model for identifying patients at risk for wild-type transthyretin amyloid cardiomyopathy

Nature Communications, 2021
Transthyretin amyloid cardiomyopathy is a treatable but often unrecognized cause of heart failure. We derived and validated a machine learning model based on medical diagnostic codes that identifies heart failure patients at risk for wild-type ...
Ahsan Huda, Adam Castaño, Anindita Niyogi, Jennifer Schumacher, Michelle Stewart, Marianna Bruno, Mo Hu, Faraz S. Ahmad, Rahul C. Deo, Sanjiv J. Shah   +9 more
doaj   +1 more source

Liver Transplantation for Transthyretin Amyloidosis

, 2009
Liver transplantation has until now proved to be the only treatment available that halts the progression of hereditary transthyretin (TTR) associated amyloidosis.
Ole B. Suhr, Lundgren, E, Ericzon, B-G, Ericzon, Bo-Göran,, Erik Lundgren, Lundgren, Erik,, Bo-Göran Ericzon, Suhr, OB, Suhr, Ole B.,   +8 more
core   +2 more sources

Stroke volume and myocardial contraction fraction in transthyretin amyloidosis cardiomyopathy: A systematic review

Frontiers in Cardiovascular Medicine, 2023
BackgroundCardiac amyloidosis (CA) is primarily a restrictive cardiomyopathy in which the impairment of diastolic function is dominant. Despite this, the left ventricular ejection fraction (LVEF) may be depressed in the late stage of the disease, but it ...
Serenelli Matteo, Cantone Anna, Sanguettoli Federico, Maio Daniele, Fabbri Gioele, Dal Passo Beatrice, Pavasini Rita, Tonet Elisabetta, Passarini Giulia, Rapezzi Claudio, Campo Gianluca   +10 more
doaj   +1 more source

Transthyretin cardiac amyloidosis.

Medicine and pharmacy reports, 2021
Transthyretin amyloid cardiomyopathy (ATTR-CM) may be an under recognized cause of heart failure (HF). TTR amyloidosis can be inherited, caused by variants in the TTR gene (ATTRv) or by deposition of wild-type TTR protein (ATTRwt), leading to high mortality if untreated.
Tomoaia, Raluca, Beyer, Ruxandra, Manole, Simona, Chirilă, Alina, Dădârlat-Pop, Alexandra, Minciună, Ioan Alexandru, Pop, Dana   +6 more
openaire   +2 more sources

The transthyretin cDNA sequence is normal in transthyretin-derived senile systemic amyloidosis [PDF]

, 1991
A variety of mutations leading to amino acid substitutions have been described in the transthyretin gene in association with different familial amyloidoses and have been implicated to be involved in the pathogenesis of amyloid deposits.
Gustavsson, Å., Betsholtz, C., L. Christmanson, Johansson, B., Sletten, K., Westermark, P., B. Johansson, K. Sletten, Christmanson, L., C. Betsholtz, Å. Gustavsson, P. Westermark   +11 more
core   +1 more source

Technetium-99m-labeled pyrophosphate uptake in the rectum of a patient with wild-type transthyretin cardiac amyloidosis

Radiology Case Reports
Wild-type transthyretin amyloidosis is a disease characterized by deposition of transthyretin amyloid protein in systemic organs and tissues, especially the heart, lungs, tenosynovium, and ligaments.
Koji Takahashi, MD, PhD, Daisuke Sasaki, MRT, Shuhei Yamamoto, MD, Nobuhisa Yamamura, MLT, Yushi Utsunomiya, MD, Hiroe Morioka, MD, Shigeki Uemura, MD, Tomoki Sakaue, MD, PhD, Katsuji Inoue, MD, PhD   +8 more
doaj   +1 more source

Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC

Fluids and Barriers of the CNS, 2018
Background Choroid plexus epithelial cells express high levels of transthyretin, produce cerebrospinal fluid and many of its proteins, and make up the blood-cerebrospinal fluid barrier. Choroid plexus epithelial cells are vital to brain health and may be
Brett A. Johnson, Margaret Coutts, Hillary M. Vo, Xinya Hao, Nida Fatima, Maria J. Rivera, Robert J. Sims, Michael J. Neel, Young-Jin Kang, Edwin S. Monuki   +9 more
doaj   +1 more source

Transthyretin as a Biomarker to Predict and Monitor Major Depressive Disorder Identified by Whole-Genome Transcriptomic Analysis in Mouse Models

Biomedicines, 2021
Background: Accumulations of stressful life events result in the onset of major depressive disorder (MDD). Comprehensive genomic analysis is required to elucidate pathophysiological changes and identify applicable biomarkers.
Sung-Liang Yu, Selina Shih-Ting Chu, Min-Hui Chien, Po-Hsiu Kuo, Pan-Chyr Yang, Kang-Yi Su   +5 more
doaj   +1 more source