Results 61 to 70 of about 51,205 (281)

Thyroid hormones correlate with resting metabolic rate, not daily energy expenditure, in two charadriiform seabirds [PDF]

, 2013
K. Woo, M. Le Vaillant, T. van Nus, and especially A. Wesphal, J. Schultner and I. Dorresteijn, assisted with field work, often under unpleasant conditions. K. Wauthier was instrumental in wrestling the gamma counter into submission. P.
Anderson, W. Gary, Elliott, Kyle H., Gaston, Anthony J., Hare, James F., Hatch, Scott A., Palace, Vince, Speakman, John R., Welcker, Jorg   +7 more
core   +2 more sources

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Amyloid Transthyretin Cardiomyopathy in Elderly Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The prevalence of calcific aortic stenosis and amyloid transthyretin cardiomyopathy (ATTR‐CM) increase with age, and they often coexist. The objective was to determine the prevalence of ATTR‐CM in patients with severe aortic stenosis and ...
Stephan Dobner, Thomas Pilgrim, Daniel Hagemeyer, Dik Heg, Jonas Lanz, Nicole Reusser, Christoph Gräni, Ali Afshar‐Oromieh, Axel Rominger, Bettina Langhammer, David Reineke, Stephan Windecker, Stefan Stortecky   +12 more
doaj   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Structure of human transthyretin complexed with bromophenols: a new mode of binding [PDF]

, 2000
The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography ...
Bergman, A, Brouwer, A, Cook, Atlanta, Ghosh, M, Johnson, L N, Meerts, I A   +5 more
core   +2 more sources

Progression and prognostic significance of electrocardiographic findings in patients with cardiac amyloidosis

ESC Heart Failure, Volume 12, Issue 2, Page 809-818, April 2025.
Abstract Aims This study aimed to evaluate the change of the main electrocardiographic (ECG) characteristics and their prognostic role across the main subtypes of cardiac amyloidosis [light‐chain amyloidosis (AL) and hereditary (ATTRv) and wild‐type transthyretin amyloidosis (ATTRwt)].
Alessia Argirò, Mattia Zampieri, Carlotta Mazzoni, Carlo Fumagalli, Michela Baccini, Alessandra Mattei, Alberto Cipriani, Laura De Michieli, Aldostefano Porcari, Gianfranco Sinagra, Marco Merlo, Giacomo Tini, Beatrice Musumeci, Domitilla Russo, Pier Filippo Vianello, Marco Canepa, Roberto Licordari, Gianluca di Bella, Claudio Rapezzi, Federico Perfetto, Francesco Cappelli   +20 more
wiley   +1 more source

Bioelectrical Impedance Analysis (BIA)-derived Phase Angle (PA) is a practical aid to nutritional assessment in hospital in-patients [PDF]

, 2019
Background: Nutritional status can be difficult to assess. Bioelectrical impedance analysis (BIA)-derived phase angle (PA), and the plasma markers citrulline and transthyretin (pre-albumin) have the potential to assist, but the protocol of fasting and ...
Alexandre, L, Chan, WY, Dutton, J, Forbes, A, Morris, P, Player, EL, Tang, J, Thomas, T, Vyas, R   +8 more
core   +1 more source

172 CLINICAL AND PROGNOSTIC IMPLICATIONS OF RV UPTAKE WITH RADIONUCLIDE SCINTIGRAPHY IN TRANSTHYRETIN CARDIAC AMYLOIDOSIS [PDF]

, 2022
Aldostefano Porcari, Marianna Fontana, Marco Canepa, Elena Biagini, Francesco Cappelli, Christian Gagliardi, Simone Longhi, Linda Pagura, Giacomo Tini, Franca Dore, Rachele Bonfiglioli, Matteo Bauckneht, Alberto Miceli, Francesca Girardi, Anna Lisa Martini, Giulia Barbati, Egidio Natalino Costanzo, Angelo Giuseppe Caponetti, Andrea Paccagnella, Maurizio Sguazzotti, Giovanni La Malfa, Mattia Zampieri, Roberto Sciagrà, Federico Perfetto, David A. Hutt, Claudio Rapezzi, Marco Merlo, Gianfranco Sinagra, Julian D. Gillmore   +28 more
openalex   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Case Report: Transthyretin Glu54Leu—a rare mutation with predominant cardiac phenotype

Frontiers in Cardiovascular Medicine, 2023
We report two unrelated Bulgarian families with hereditary transthyretin (ATTR) amyloidosis due to a rare p.Glu74Leu (Glu54Leu) pathogenic variant found in seven individuals—three of them symptomatic.
Mariana Gospodinova, Sashka Zhelyazkova, Teodora Chamova, Ognyan Asenov, Zornitsa Pavlova, Tihomir Todorov, Dilyana Mikova, Yordan Palashev, Yordan Palashev, Ivan Gruev, Atanas Kundurdjiev, Atanas Kundurdjiev, Albena Todorova, Albena Todorova, Ivailo Tournev, Ivailo Tournev   +15 more
doaj   +1 more source