Results 81 to 90 of about 51,205 (281)

Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition [PDF]

, 2018
Each of the 30 human amyloid diseases is associated with the aggregation of a particular precursor protein into amyloid fibrils. In transthyretin amyloidosis (ATTR), mutant or wild-type forms of the serum carrier protein transthyretin (TTR), synthesized ...
Benson, Merrill D., Chung, Kevin, Cohn, Whitaker, Eisenberg, David S., Lee, Ji H., Saelices, Lorena, Whitelegge, Julian P.   +6 more
core   +1 more source

Exercise limitations in amyloid cardiomyopathy assessed by cardiopulmonary exercise testing—A multicentre study

ESC Heart Failure, Volume 12, Issue 2, Page 1326-1335, April 2025.
Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved or reduced ejection fraction.
Robin Willixhofer, Mauro Contini, Michele Emdin, Damiano Magrì, Alice Bonomi, Elisabetta Salvioni, Fabrizio Celeste, Alberico Del Torto, Claudio Passino, Christophe D.J. Capelle, Chiara Arzilli, Emiliano Fiori, Nicolò Capra, Christina Kronberger, Nikita Ermolaev, Andreas Kammerlander, Beatrice Musumeci, Giuseppe Vergaro, Vincenzo Castiglione, René Rettl, Giacomo Tini, Andrea Baggiano, Iacopo Fabiani, Susanna Sciomer, Roza Badr Eslam, Piergiuseppe Agostoni   +25 more
wiley   +1 more source

Transthyretin promotes the invasion of combined hepatocellular cholangiocarcinoma by tumor‐associated macrophages

Cancer Reports, 2023
Background Patients with combined hepatocellular‐cholangiocarcinoma (cHCC‐CCA) have limited treatment options and poor prognosis. Tumor‐associated macrophages (TAMs) are the most abundant infiltrating immune cells in the tumor microenvironment and ...
Kun Ke, Junqing Lin, Ning Huang, Leye Yan, Rihua Liao, Weizhu Yang   +5 more
doaj   +1 more source

Transthyretin is a metallopeptidase with an inducible active site [PDF]

, 2012
TTR (transthyretin) was found recently to possess proteolytic competency besides its well-known transport capabilities. It was described as a cryptic serine peptidase cleaving multiple natural substrates (including beta-amyloid and apolipoprotein A-I ...
Bur, Daniel, Damas, Ana M., Juliano, Luiz, Leite, Sergio C., Liz, Marcia A., Saraiva, Maria J., Sousa, Monica M.   +6 more
core   +2 more sources

Familial Amyloidotic Polyneuropathy with Leptomeningeal and Cardiac Involvement in a Patient with Gly73Glu Transthyretin Gene Mutation — Non-invasive Diagnostic Approach with Multimodality Imaging Findings: a Case Report [PDF]

, 2022
BCK Chow, SSM Lo, JCY Lee, JB Chiang, HF Chan, CB Ho, L. D. Szeto, KW Tang   +7 more
openalex   +1 more source

Serum Transthyretin [PDF]

Circulation: Heart Failure, 2018
See Article by Hanson et al > The future depends on what you do today. > > ―Mahatma Gandhi A biomarker is defined by the National Institutes of Health Biomarkers Definitions Working Group as “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses ...
openaire   +2 more sources

Single-centre experience on transthyretin familial amyloid polyneuropathy : case series and literature review [PDF]

, 2018
Familial amyloid polyneuropathy (FAP) is a most often length-dependent axonal neuropathy, often part of a multisystem disorder also affecting other organs, such as cardiac, gastrointestinal, genitourinary, renal, meningeal and eye tissue.
De Bleecker, Jan, De Pauw, Michel, Martens, Broes   +2 more
core   +2 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Prevalence and characteristics of transthyretin amyloid cardiomyopathy in hypertrophic cardiomyopathy

ESC Heart Failure
Aims Recognition of transthyretin amyloid cardiomyopathy is increasing due to advances in cardiac imaging and diagnostic strategies, but questions remain regarding disease frequency and characteristics.
Pablo Garcia‐Pavia, Thibaud Damy, Nicolas Piriou, Roberto Barriales‐Villa, Francesco Cappelli, Catherine Bahus, Carmen Munteanu, Denis Keohane, Pablo Mallaina, Perry Elliott, the TTRACK investigators   +10 more
doaj   +1 more source

Serum Transthyretin Level as a Plausible Marker for Diagnosis of Child Acute Malnutrition

Biochemistry Research International, 2017
Malnutrition is a major underlying condition for mortality in children under five years of age in developing countries, particularly in Ethiopia. The most important forms of malnutrition in Ethiopia are protein and energy deficiencies.
Behailu Tsegaye, Amha Mekasha, Solomon Genet   +2 more
doaj   +1 more source