Results 81 to 90 of about 10,856 (192)

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Top‐Down CSF Peptidomics Reveals Disease‐Associated Peptide Signatures and Oxidative Modifications in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

PROTEOMICS, EarlyView.
ABSTRACT Multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory demyelinating diseases of the CNS whose diagnosis is mainly based on clinical evidence, magnetic resonance imaging, and the analysis of cerebrospinal fluid (CSF). Current approaches provide only partial insight into disease‐related biological processes, thus
Cristina Contini, Lorena Lorefice, Greca Lai, Alessandra Schirru, Giorgia Zodio, Tiziana Cabras, Alessandra Olianas, Giacomo Diaz, Eleonora Cocco, Barbara Manconi   +9 more
wiley   +1 more source

Transthyretin is a promising prognostic marker of non-developing pregnancy in hypothyroidism

Фундаментальная и клиническая медицина
Non-developing pregnancy is one of the most important problems in the practice of an obstetrician-gynecologist. Transthyretin is a transplacental transport protein of T3, T4 and is expressed in cyto- and syncytiotrophoblast cells.
A. A. Orazmuradov, J. D. Suleymanova, E. A. Kuzmina, E. V. Mukovnikova, Kh. Haddad, A. N. Akhmatova   +5 more
doaj   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Protein mis-folding and human disease

, 2010
Serum Amyloid P Component (SAP), a putative molecular chaperone, is a homopentamericplasma protein of 25kDa subunits. It binds to the amyloid fibrils ofmisfolded proteins, which cause amyloidosis in humans. SAP not only stabilizesamyloid fibrils but also
Pal, Mohinder
core   +1 more source

Serum transthyretin in hemodialysis patients : relationship to nutritional status [PDF]

, 1997
The validity of serum transthyretin as a nutrition assessment parameter in hemodialysis patients was investigated. Fifty-one subjects (39% male and 61 % female; 53% black, 28% white, 12% Hispanic, 7% Other) receiving hemodialysis for 30 24 months (mean ...
Duggan, Annmarie
core   +1 more source

Diuretic Dose and NYHA Functional Class Are Independent Predictors of Mortality in Patients With Transthyretin Cardiac Amyloidosis

JACC. CardioOncology, 2020
Background: With increasing diagnoses and available treatment options for transthyretin amyloidosis cardiomyopathy (ATTR-CM), risk stratification of ATTR-CM patients is imperative.
Richard K. Cheng, MD, MSc, Wayne C. Levy, MD, Alexi Vasbinder, RN, Sergio Teruya, MD, Jeffeny De Los Santos, MD, Douglas Leedy, MD, Mathew S. Maurer, MD   +6 more
doaj   +1 more source

Asymptotic r2 Enhancement in Formulation‐Optimized Lipid‐Iron Oxide Nanoparticles for Assessing Glioblastoma Heterogeneity at Ultrahigh‐Field MRI

Small, EarlyView.
Lipid‐coated superparamagnetic iron oxide nanoparticles (LSPIONs) are developed as MRI‐visible lipid nanocarriers for glioblastoma imaging. By tuning nanoparticle size and SPION loading, their transverse relaxivity (r2) can be systematically controlled over one order of magnitude, reaching 390 mm−1 s−1 at 9.4 T.
Marcos Bazarra‐Barreiros, María Teresa Abengoza‐Bello, Sabela Fernández‐Rodicio, Sara Ortega‐Espina, Lucía García‐Astray, José Castillo, Ramón Iglesias‐Rey, Pelayo García‐Acevedo, Pablo Hervella   +8 more
wiley   +1 more source

Small molecule amyloid disrupters demonstrate therapeutic efficacy for transthyretin amyloidosis [PDF]

The escalating global trend of an aging population has brought attention to the rising prevalence of late-onset amyloid disorders. Among them, transthyretin amyloidosis (ATTR) presents a growing medical challenge, particularly in the elderly.
Genki, Kudo, Youhei, Sohma, Moe, Toyobe, Yukiko, Hori, Mina, Yamane, Shigehiro A., Kawashima, Hiroki, Umeda, Yukio, Ando, Masamitsu, Okada, Motomu, Kanai, Takatsugu, Hirokawa, Atsushi, Iwai, Mitsuharu, Ueda, Taisuke, Tomita, Kunitoshi, Yamanaka, Harunobu, Mitsunuma, Mineyuki, Mizuguchi   +16 more
core   +1 more source

Transthyretin amyloid cardiomyopathy

, 2020
Transthyretin amyloid cardiomyopathy (ATTR-CM) resulting from deposition of transthyretin amyloid fibrils in the heart is an underrecognised cause of heart failure in the elderly and is associated with a poor life expectancy.
Hansen, Peter Riis, Krakauer, Martin
core   +1 more source