Results 91 to 100 of about 10,856 (192)

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly, Andrew Barrick, Tham C. Hoang, Ramon Lavado   +3 more
wiley   +1 more source

New Medications in the Treatment of Hereditary Transthyretin Amyloidosis

, 2018
Hereditary transthyretin amyloidosis is an inherited disorder that results in the gradual progressive deposit of abnormal protein called amyloid in the body’s organs and tissues.
Scot Walker
core   +1 more source

Serum transthyretin combined with first trimester uterine artery doppler ultrasound for preeclampsia prediction in singleton pregnancies: a prospective observational study

Scientific Reports
This study aimed to evaluate the predictive value of serum transthyretin levels in conjunction with uterine artery Doppler ultrasound during the first trimester for predicting preeclampsia.
Siraphat Fungtammasan, Vorapong Phupong
doaj   +1 more source

Transthyretin Amyloidosis Due to a Rare TTR Val142del Deletion With Relatively Early Clinical Manifestations

JACC: Case Reports
Background: Hereditary transthyretin amyloidosis shows marked phenotypic heterogeneity. In-frame deletions at codon 142 are exceedingly rare, and their cardiac expression remains poorly characterized.
Cristhian Espinoza Romero, MD, Kevin De Paula Morales, MD, Christiane Espirito Santo, MD, Guilherme dos Santos Ferreira, MD, Alan Silva Martins, MD, Bruno Vaz Kerges Bueno, MD, Fabio Fernandes, MD, PhD   +6 more
doaj   +1 more source

Cardiometabolic Protein Profile Changes During Gender‐Affirming Hormone Therapy: A Prospective Clinical Study

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Cardiovascular disease (CVD) risk is elevated in transgender individuals during gender‐affirming hormone therapy (GAHT) with expected different mechanisms between T‐ and E2‐based GAHT. We investigated prospective changes in cardiometabolic proteins relating to complement, inflammation, and transport during GAHT.
Emilie Bukh Madsen, Louise Lehmann Christensen, Sara Ravn Bach, Louise Skøttrup Christiansen, Mathilde Kamp Nørlund, Tine Taulbjerg Kristensen, Guy T'Sjoen, Anne Pernille Hermann, Camilla Viola Buskbjerg Palm, Jan Frystyk, Marianne Skovsager Andersen, Martin Overgaard, Dorte Glintborg   +12 more
wiley   +1 more source

Specific therapeutic options for transthyretin amyloidosis

The epidemiology of systemic amyloidosis has recently undergone a spectacular transformation. While light-chain amyloidosis remains a rare disease with a stable incidence, chronic inflammatory disease associated amyloidosis (AA) is diagnosed less ...
Zoltán Pozsonyi
core   +1 more source

Characterising differential maturation of stem cell‐derived islets in mice: Graft function and transcriptomic analysis

Diabetic Medicine, EarlyView.
Abstract Aims Stem cell‐derived islets (SC‐islets) offer the potential to revolutionise type 1 diabetes treatment. However, functional maturation in vivo is variable, suggesting that specific, but as‐yet undefined, environmental cues are critical. We aimed to identify pathways associated with SC‐islet in vivo maturation in mice, assess early functional
Rosie Sullivan, Lydia F. Daniels Gatward, Tzu‐Wen Hong, Zekun Lyu, William T. Blackstone Whines, Claire Duff, Ryea Arora, Adya Lonsane, Min Zhao, Victoria Salem, Aileen J. F. King, Peter M. Jones, Shanta J. Persaud   +12 more
wiley   +1 more source

Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy

, 2013
Transthyretin can cause amyloidosis attributable to destabilization of transthyretin tetramers in plasma. We tested the hypothesis that genetic stabilization of transthyretin associates with reduced risk of vascular disease and increased life expectancy.
Tybjærg-Hansen, Anne, Frikke-Schmidt, Ruth, Nordestgaard, Børge G, Hornstrup, Louise S   +3 more
core   +1 more source

The hydrophobic C‐terminal sequence of transthyretin affects its catalytic kinetics towards amidated neuropeptide Y

FEBS Open Bio, 2019
Transthyretin (TTR) is a transporter for thyroid hormone and retinol binding protein that has recently been reported to have proteolytic activity against certain substrates, including amidated neuropeptide Y (NPY).
Sukanya Tangthavewattana, Ladda Leelawatwattana, Porntip Prapunpoj   +2 more
doaj   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source