Results 91 to 100 of about 28,989 (238)
Neuroprotection, EarlyView.Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji +4 more
wiley +1 more source
Low transthyretin concentration linked to adverse prognosis in elderly inpatients
BMC GeriatricsBackground To investigate the association between low transthyretin (prealbumin) concentration and mortality or readmission for all causes in elderly inpatients.
Ting Wang +9 more
doaj +1 more source
The two shapes of the Tau protein
eLife, 2018 Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer’s disease.
Jeffery W Kelly
doaj +1 more source
SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies
PROTEOMICS, EarlyView.ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà +10 more
wiley +1 more source
Transthyretin is a promising prognostic marker of non-developing pregnancy in hypothyroidism
Фундаментальная и клиническая медицинаNon-developing pregnancy is one of the most important problems in the practice of an obstetrician-gynecologist. Transthyretin is a transplacental transport protein of T3, T4 and is expressed in cyto- and syncytiotrophoblast cells.
A. A. Orazmuradov +5 more
doaj +1 more source
Small molecule amyloid disrupters demonstrate therapeutic efficacy for transthyretin amyloidosis
The escalating global trend of an aging population has brought attention to the rising prevalence of late-onset amyloid disorders. Among them, transthyretin amyloidosis (ATTR) presents a growing medical challenge, particularly in the elderly.
Genki, Kudo +16 more
core +1 more source
Precision Radiation Oncology, EarlyView.Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen +6 more
wiley +1 more source
Helical reconstruction of amyloids in cryoSPARC
Acta Crystallographica Section F, EarlyView.We present practical guidelines for helical reconstruction of amyloid filaments in cryoSPARC, benchmarked against publicly available datasets. Our analysis defines current capabilities and limitations, and outlines optimization strategies to enable high‐throughput structural studies and therapeutic discovery.Amyloid‐mediated proteotoxicity underlies ...
Jan-Hannes Schaefer +5 more
wiley +1 more source
Systemic transthyretin amyloidosis: carpal tunnel syndrome in a Portuguese population (CarPoS) [PDF]
Exploration of CardiologyCarpal tunnel syndrome (CTS) is the most common type of entrapment neuropathy and affects approximately 1% to 5% of the general population, mostly patients older than 50 years.
Sofia Pimenta +11 more
doaj +1 more source
Specific therapeutic options for transthyretin amyloidosis
The epidemiology of systemic amyloidosis has recently undergone a spectacular transformation. While light-chain amyloidosis remains a rare disease with a stable incidence, chronic inflammatory disease associated amyloidosis (AA) is diagnosed less ...
Zoltán Pozsonyi
core +1 more source