Results 91 to 100 of about 51,205 (281)
Transthyretin: a multifaceted protein
BioMolecular Concepts, 2014 AbstractTransthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. Behavior, cognition, neuropeptide amidation, neurogenesis, nerve regeneration, axonal growth and 14-3-3ζ ...
Vieira Marta, Saraiva Maria João
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SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies
PROTEOMICS, EarlyView.ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà +10 more
wiley +1 more source
Synthesis and structural analysis of the N-terminal domain of the thyroid hormone-binding protein transthyretin [PDF]
, 2002 Transthyretin (TTR) is a 55 kDa protein responsible for the transport of thyroid hormones and retinol in human serum. Misfolded forms of the protein are implicated in the amyloid diseases familial amyloidotic polyneuropathy and senile systemic ...
Hamilton JA +9 more
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Comparative Stability and Clearance of [Met30]Transthyretin and [Met119]Transthyretin [PDF]
European Journal of Biochemistry, 1997 [Met119]Transthyretin has been described as a non‐amyloidogenic transthyretin variant. In Portugal, it has also been found in compound heterozygotic individual carriers of [Met30]transthyretin, the most prevalent variant associated with familial amyloidotic polyneuropathy.
I, Longo Alves, M T, Hays, M J, Saraiva
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Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury
Cell Proliferation, EarlyView.Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy +7 more
wiley +1 more source
Fish and amphibians as test organisms for evaluation of effects caused by chemicals [PDF]
, 2007 A large number of chemicals can contaminate aquatic environments and therefore be exposed to fish and amphibians during their sensitive stages of development.
Carlsson, Gunnar
core
EE526 Cost-Effectiveness Analysis of Transthyretin-Associated Amyloid Cardiomyopathy from the Brazilian Public Healthcare System Perspective [PDF]
, 2023 Maria João Sebastião +4 more
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Journal of Cardiovascular Electrophysiology, EarlyView.ABSTRACT Background Cardiac amyloidosis is commonly associated with cardiac conduction disease. We sought to determine the prevalence of advanced conduction disease requiring a pacemaker in patients with known cardiac amyloidosis to evaluate current screening practices among patients receiving pacemakers.
Peishan Cai +4 more
wiley +1 more source
The proteostasis network and its decline in ageing
, 2019 Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
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