Results 71 to 80 of about 32,046 (240)

A clinical case of hereditary transthyretin amyloidosis with predominant involvement of the peripheral nervous system

Анналы клинической и экспериментальной неврологии
Hereditary transthyretin amyloidosis is a fatal systemic progressive disease caused by mutations in the transthyretin (TTR) gene, inherited in an autosomal dominant pattern, primarily affecting the peripheral and autonomic nervous systems and the heart ...
Elizaveta A. Guseva, Natalia A. Suponeva, Marianna V. Mukhacheva   +2 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Prevalence and characteristics of transthyretin amyloid cardiomyopathy in hypertrophic cardiomyopathy

ESC Heart Failure
Aims Recognition of transthyretin amyloid cardiomyopathy is increasing due to advances in cardiac imaging and diagnostic strategies, but questions remain regarding disease frequency and characteristics.
Pablo Garcia‐Pavia, Thibaud Damy, Nicolas Piriou, Roberto Barriales‐Villa, Francesco Cappelli, Catherine Bahus, Carmen Munteanu, Denis Keohane, Pablo Mallaina, Perry Elliott, the TTRACK investigators   +10 more
doaj   +1 more source

Serum Transthyretin Level as a Plausible Marker for Diagnosis of Child Acute Malnutrition

Biochemistry Research International, 2017
Malnutrition is a major underlying condition for mortality in children under five years of age in developing countries, particularly in Ethiopia. The most important forms of malnutrition in Ethiopia are protein and energy deficiencies.
Behailu Tsegaye, Amha Mekasha, Solomon Genet   +2 more
doaj   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

The two shapes of the Tau protein

eLife, 2018
Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer’s disease.
Jeffery W Kelly
doaj   +1 more source

Transthyretin-thyroid hormone internalization by trophoblasts

, 2013
Normal fetal neurological development depends on a regulated supply of maternal thyroid hormone (TH). We have previously demonstrated that transthyretin (TTR) a TH binding protein, is synthesized, secreted and internalized by trophoblast cells and may ...
Richard, K., Subramaniam, V. N., Landers, K.A., Li, H., Mortimer, R.H., Landers, K. A., Mortimer, R. H., Subramaniam, V.N.   +7 more
core   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly, Andrew Barrick, Tham C. Hoang, Ramon Lavado   +3 more
wiley   +1 more source