Results 71 to 80 of about 560,049 (292)

The great mimicker: Multimodality imaging in cardiac sarcoidosis

Romanian Journal of Cardiology
Cardiac sarcoidosis is a granulomatous inflammatory disease that can mimic genetic cardiomyopathies, making diagnosis challenging, particularly in young patients with preserved ventricular function.
Neculae Gabriela, Chadhaa Gagan Deep Singh, Hentati Mouna, Oghina Silvia, Damy Thibaud   +4 more
doaj   +1 more source

Tracheal Amyloidosis Presenting as Life Threatening Airway Obstruction [PDF]

Journal of Clinical and Diagnostic Research, 2017
We hereby present a case of a 62-year-old man who presented with tracheostomy in situ for the last two years and unexplained etiology for the life-threatening airway compromise.
Alkesh Kumar Khurana, Vikas Gupta, Abhishek Goyal, Ganakalyan Behera, Garima Goel   +4 more
doaj   +1 more source

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

, 2015
Item does not contain fulltextIMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are
Fagan, A.M., Madsen, K., Prabhakar, S., Alcolea, D., Ramakers, I.H., Nordberg, A., Spiru, L., Waldemar, G., Alexander, M., Scheltens, P., Drzezga, A., Zboch, M., Leon, M., Freund-Levi, Y., Herukka, S.K., Hellwig, S., Kohler, S., Sarazin, M., Chetelat, G., Rodriguez-Rodriguez, E., Aalten, P., Ivanoiu, A., Johannsen, P., Teunissen, C.E., Forster, S., Novak, G.P., Blennow, K., Sanchez-Juan, P., Verhey, F.R.J., van Buchem, M.A., Gkatzima, O., Klunk, W.E., Meulenbroek, O., Mroczko, B., Verhey, F.R., Almdahl, I.S., Bibeau, K., Fladby, T., Møllergård, H.M., Struyfs, H., Vos, S.J., Schütte, C., Camus, V., Lleo, A., Frederiksen, K.S., van der Flier, W.M., Baldeiras, I., Hildebrandt, H., Chen, K., Froelich, L., Koglin, N., Lisetti, V., Gordon, M.F., Rowe, C.C., Foskett, N., Meulenbroek, O.V., Kornhuber, J., Mollergard, H.M., Cavedo, E., Gill, K.D., Rodrigue, K.M., Scheltens, P.J., Aarsland, D., Newberg, A., Wolk, D.A., Hampel, H., Roe, C.M., Vandenberghe, R., Parnetti, L., Peters, O., Verbeek, M.M., Tijms, B.M., Ishihara, L., Kramberger, M.G., Mintun, M.A., Rot, U., Zetterberg, H., Villemagne, V.L., Mattsson, N., Morris, J.C., Soininen, H., Mussele, S. Van der, Laere, K. Van, Brooks, D.J., Ossenkoppele, R., de Mendonça, A., Wallin, Å.K., Grimmer, T., Van Laere, K., Landau, S.M., Sabri, O., Na, D.L., Oliveira, C.R., Rinne, J.O., Soetewey, F., Gomez-Tortosa, E., Rüther, E., van Waalwijk van Doorn, L.J., Fleisher, A.S., Kapaki, E., Buchem, M.A. van, Meyer, P.T., Hausner, L., Schröder, J., Berckel, B.N. van, Rabinovici, G.D., Frisoni, G.B., Ford, L., van Berckel, B.N., Rami, L., Gabryelewicz, T., Mendonca, A. de, et al., Fortea, J., Flier, W.M. van der, Wallin, A., Jansen, W.J., Visser, P.J., Knol, D.L., Maier, W., Cohen, A.D., Lee, D.Y., Wiltfang, J., Paraskevas, G.P., Mok, V., Arnold, S.E., Marcusson, J., Tsolaki, M., Barthel, H., Santana, I., Klimkowicz-Mrowiec, A., Molinuevo, J.L., Engelborghs, S., Resende de Oliveira, C., Nordlund, A., Perera, G., de Leon, M., Kandimalla, R., Popp, J., Jagust, W.J., Seo, S.W., Van der Mussele, S.   +141 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Prognostic mortality factors in advanced light chain cardiac amyloidosis: A prospective cohort study

ESC Heart Failure
Aims Predicting mortality in severe AL cardiac amyloidosis is challenging due to elevated biomarker levels and limited thresholds for stratifying severe cardiac damage.
Amira Zaroui, Mounira Kharoubi, Romain Gounot, Silvia Oghina, Charlotte Degoutte, Melanie Bezard, Arnault Galat, Soulef Guendouz, Louise Roulin, Vincent Audard, Vincent Leroy, Emmanuel Teiger, Elsa Poullot, Valérie Molinier‐Frenkel, Fabien Le Bras, Karim Belhadj, Jean‐Philippe Bastard, Soraya Fellahi, Jason Shourick, Francois Lemonier, Thibaud Damy   +20 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Quantitative Proteomics of Plasma-Derived Extracellular Vesicles Reveals a Plasminogen-Centered Protein Network in Transthyretin Cardiac Amyloidosis

JACC: Advances
Background: The prognosis of patients with transthyretin cardiac amyloidosis (ATTR) remains poor; this is primarily due to late diagnosis, when irreversible damage has already occurred.
Amira Zaroui, MD, Damien Habert, MSc, Benoit Vallée, MSc, Mounira Kharoubi, PhD, Soraya Fellahi, PharmD, Benoit Vingert, PhD, Michel Seve, PharmD, PhD, Ilaria Cascone, PhD, Vincent Audard, MD, PhD, Emmanuel Itti, MD, PhD, Hajer Abroud, PharmD, Arnault Galat, MD, Thibaud Damy, MD, PhD, Sandrine Bourgoin-Voillard, PhD, Valérie Molinier-Frenkel, MD, PhD   +14 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Diagnostic Trends and Geographic Health Care Disparities Among Patients With Transthyretin Amyloid Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a rare, life‐threatening form of restrictive cardiomyopathy. Access to cardiology providers and specialized amyloid centers may impact ATTR‐CM diagnosis.
Joshua D. Mitchell, Kevin M. Alexander, Hanh Dung Dao, Elizabeth Nagelhout, Neil Lamarre, Margarita Udall, Richard K. Cheng   +6 more
doaj   +1 more source