Results 71 to 80 of about 547,277 (291)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The great mimicker: Multimodality imaging in cardiac sarcoidosis

Romanian Journal of Cardiology
Cardiac sarcoidosis is a granulomatous inflammatory disease that can mimic genetic cardiomyopathies, making diagnosis challenging, particularly in young patients with preserved ventricular function.
Neculae Gabriela, Chadhaa Gagan Deep Singh, Hentati Mouna, Oghina Silvia, Damy Thibaud   +4 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Prognostic mortality factors in advanced light chain cardiac amyloidosis: A prospective cohort study

ESC Heart Failure
Aims Predicting mortality in severe AL cardiac amyloidosis is challenging due to elevated biomarker levels and limited thresholds for stratifying severe cardiac damage.
Amira Zaroui, Mounira Kharoubi, Romain Gounot, Silvia Oghina, Charlotte Degoutte, Melanie Bezard, Arnault Galat, Soulef Guendouz, Louise Roulin, Vincent Audard, Vincent Leroy, Emmanuel Teiger, Elsa Poullot, Valérie Molinier‐Frenkel, Fabien Le Bras, Karim Belhadj, Jean‐Philippe Bastard, Soraya Fellahi, Jason Shourick, Francois Lemonier, Thibaud Damy   +20 more
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

, 2015
Item does not contain fulltextIMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are
Fagan, A.M., Madsen, K., Prabhakar, S., Alcolea, D., Ramakers, I.H., Nordberg, A., Spiru, L., Waldemar, G., Alexander, M., Scheltens, P., Drzezga, A., Zboch, M., Leon, M., Freund-Levi, Y., Herukka, S.K., Hellwig, S., Kohler, S., Sarazin, M., Chetelat, G., Rodriguez-Rodriguez, E., Aalten, P., Ivanoiu, A., Johannsen, P., Teunissen, C.E., Forster, S., Novak, G.P., Blennow, K., Sanchez-Juan, P., Verhey, F.R.J., van Buchem, M.A., Gkatzima, O., Klunk, W.E., Meulenbroek, O., Mroczko, B., Verhey, F.R., Almdahl, I.S., Bibeau, K., Fladby, T., Møllergård, H.M., Struyfs, H., Vos, S.J., Schütte, C., Camus, V., Lleo, A., Frederiksen, K.S., van der Flier, W.M., Baldeiras, I., Hildebrandt, H., Chen, K., Froelich, L., Koglin, N., Lisetti, V., Gordon, M.F., Rowe, C.C., Foskett, N., Meulenbroek, O.V., Kornhuber, J., Mollergard, H.M., Cavedo, E., Gill, K.D., Rodrigue, K.M., Scheltens, P.J., Aarsland, D., Newberg, A., Wolk, D.A., Hampel, H., Roe, C.M., Vandenberghe, R., Parnetti, L., Peters, O., Verbeek, M.M., Tijms, B.M., Ishihara, L., Kramberger, M.G., Mintun, M.A., Rot, U., Zetterberg, H., Villemagne, V.L., Mattsson, N., Morris, J.C., Soininen, H., Mussele, S. Van der, Laere, K. Van, Brooks, D.J., Ossenkoppele, R., de Mendonça, A., Wallin, Å.K., Grimmer, T., Van Laere, K., Landau, S.M., Sabri, O., Na, D.L., Oliveira, C.R., Rinne, J.O., Soetewey, F., Gomez-Tortosa, E., Rüther, E., van Waalwijk van Doorn, L.J., Fleisher, A.S., Kapaki, E., Buchem, M.A. van, Meyer, P.T., Hausner, L., Schröder, J., Berckel, B.N. van, Rabinovici, G.D., Frisoni, G.B., Ford, L., van Berckel, B.N., Rami, L., Gabryelewicz, T., Mendonca, A. de, et al., Fortea, J., Flier, W.M. van der, Wallin, A., Jansen, W.J., Visser, P.J., Knol, D.L., Maier, W., Cohen, A.D., Lee, D.Y., Wiltfang, J., Paraskevas, G.P., Mok, V., Arnold, S.E., Marcusson, J., Tsolaki, M., Barthel, H., Santana, I., Klimkowicz-Mrowiec, A., Molinuevo, J.L., Engelborghs, S., Resende de Oliveira, C., Nordlund, A., Perera, G., de Leon, M., Kandimalla, R., Popp, J., Jagust, W.J., Seo, S.W., Van der Mussele, S.   +141 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Diagnostic Trends and Geographic Health Care Disparities Among Patients With Transthyretin Amyloid Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a rare, life‐threatening form of restrictive cardiomyopathy. Access to cardiology providers and specialized amyloid centers may impact ATTR‐CM diagnosis.
Joshua D. Mitchell, Kevin M. Alexander, Hanh Dung Dao, Elizabeth Nagelhout, Neil Lamarre, Margarita Udall, Richard K. Cheng   +6 more
doaj   +1 more source

On Amyloid Protein [PDF]

Medical Humanities, 2017
I watch your eyes tracing my face. Furrowed brows suggest blurred image. Slow, slow, not in haste— Mine is a forgotten visage, Erased …
openaire   +2 more sources

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source