Results 71 to 80 of about 504,545 (312)

Exploring the sequence–structure relationship for amyloid peptides [PDF]

, 2012
Amyloid fibril formation is associated with misfolding diseases, as well as fulfilling a functional role. The cross-β molecular architecture has been reported in increasing numbers of amyloid-like fibrillar systems. The Waltz algorithm is able to predict
Morris, Kyle L., Rousseau, F. (Frederic), Maya Debulpaep (16158989), Rodger, Alison, Frederic Rousseau (5872), Schymkowitz, Joost, Joost Schymkowitz (5868), Serpell, Louise C., Matthew R Hicks (16064381), Louise Serpell (4461124), Rousseau, Frederic, Hicks, Matthew R., Kyle L Morris (9164846), Alison Rodger (282425), Debulpaep, Maya   +14 more
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Diagnostic Trends and Geographic Health Care Disparities Among Patients With Transthyretin Amyloid Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a rare, life‐threatening form of restrictive cardiomyopathy. Access to cardiology providers and specialized amyloid centers may impact ATTR‐CM diagnosis.
Joshua D. Mitchell, Kevin M. Alexander, Hanh Dung Dao, Elizabeth Nagelhout, Neil Lamarre, Margarita Udall, Richard K. Cheng   +6 more
doaj   +1 more source

Amyloid imaging

International Psychogeriatrics, 2011
Molecular neuroimaging techniques such as PET are proving valuable in the early and differential diagnosis of Alzheimer's disease (AD).With the advent of new therapeutic strategies aimed at reducing β-amyloid (Aβ) burden in the brain to potentially prevent or delay functional and irreversible cognitive loss, there is increased interest in developing ...
Victor L, Villemagne, Christopher C, Rowe   +1 more
openaire   +2 more sources

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes [PDF]

, 2014
Aims/hypothesis: Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP ...
Hamilton, D. Lee, Montagut , Gemma, Meakin, Paul J., Susan M. Jalicy, Meakin, PJ, D. Lee Hamilton, Dawn Bestow, Bestow, D, Hamilton, DL, Montagut, G, Michael L. J. Ashford, Jalicy, Susan M., Findlay, John A., Jalicy, SM, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, Montagut, Gemma, John A. Findlay, Gemma Montagut, Meakin, Paul J, Ashford, Michael L J, Bestow, Dawn, Findlay, John A, Jalicy, Susan M, Hamilton, David Lee, Findlay, JA, Paul J. Meakin   +26 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Association of Cerebral Amyloid-beta Aggregation With Cognitive Functioning in Persons Without Dementia

, 2018
Importance: Cerebral amyloid-beta aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the ...
Fagan, A.M., Madsen, K., Alcolea, D., Nordberg, A., Spiru, L., Waldemar, G., Alexander, M., Scheltens, P., Rodríguez-Rodríguez, E., Zboch, M., Drzezga, A., Leon, M., Freund-Levi, Y., Herukka, S.K., Sarazin, M., Hellwig, S., Kohler, S., Chetelat, G., Aalten, P., Ivanoiu, A., Johannsen, P., Teunissen, C.E., Forster, S., Novak, G.P., Sanchez-Juan, P., Blennow, K., Verhey, F.R.J., van Buchem, M.A., Chipi, E., Gkatzima, O., Klunk, W.E., Meulenbroek, O., Mroczko, B., Almdahl, I.S., Fladby, T., Stomrud, E., Møllergård, H.M., Struyfs, H., van Waalwijk van Doorn, LJC, Camus, V., Lleo, A., Frederiksen, K.S., van der Flier, W.M., Baldeiras, I., Hildebrandt, H., Froelich, L., Chen, K., Koglin, N., Lisetti, V., Rowe, C.C., Gordon, M.F., Kornhuber, J., Mollergard, H.M., Cavedo, E., Vos, SJB, Newberg, A., Wolk, D.A., Aarsland, D., Hampel, H., Roe, C.M., Vandenberghe, R., Parnetti, L., Peters, O., Verhey, FRJ, Verbeek, M.M., Tijms, B.M., Mintun, M.A., Kramberger, M.G., Rot, U., Zetterberg, H., Villemagne, V.L., Mattsson, N., Morris, J.C., Soininen, H., Laere, K. Van, Brooks, D.J., Ossenkoppele, R., de Mendonça, A., Wallin, Å.K., Grimmer, T., Landau, S.M., Sabri, O., Na, D.L., Rinne, J.O., Rüther, E., Fleisher, A.S., Kapaki, E., Buchem, M.A. van, Meyer, P.T., Hausner, L., Schröder, J., Rabinovici, G.D., Berckel, B.N. van, Frisoni, G.B., Ramakers, I., et al., Ramakers, IHGB, Rami, L., Gabryelewicz, T., Mendonca, A. de, Fortea, J., Flier, W.M. van der, Wallin, A., Jansen, W.J., Visser, P.J., Maier, W., Hansson, O., Cohen, A.D., Lee, D.Y., van Laere, K., van Berckel, BNM, Wiltfang, J., Paraskevas, G.P., Mok, V., Arnold, S.E., Marcusson, J., Tsolaki, M., Oliveira, C. de, Barthel, H., Santana, I., Klimkowicz-Mrowiec, A., Molinuevo, J.L., Engelborghs, S., Resende de Oliveira, C., Nordlund, A., Perera, G., de Leon, M., Popp, J., Jagust, W.J., Seo, S.W.   +128 more
core   +1 more source

The role of amyloid precursor proteins : studies using neurons generated from wild-type and mutant embryonic stem cells [PDF]

, 2006
Alzheimer′s Disease (AD) is the most common neurodegenerative disorder in elderly people. It is becoming an ever larger problem due to prolonged life-expectancies in developed countries.
Schrenk, Katrin
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source