Results 31 to 40 of about 405,002 (265)

AL Amyloidosis for the Cardiologist and Oncologist

JACC. CardioOncology, 2019
AL amyloidosis results from clonal production of immunoglobulin light chains, most commonly arising from a clonal plasma cell disorder. Once considered a nearly uniformly fatal disease, prognosis has improved markedly over the past 15 years ...
Ronald M. Witteles, MD, Michaela Liedtke, MD   +1 more
doaj   +1 more source

Exploring Biomolecular Self-Assembly with Far-Infrared Radiation

Biomolecules, 2022
Physical engineering technology using far-infrared radiation has been gathering attention in chemical, biological, and material research fields. In particular, the high-power radiation at the terahertz region can give remarkable effects on biological ...
Takayasu Kawasaki, Yuusuke Yamaguchi, Hideaki Kitahara, Akinori Irizawa, Masahiko Tani   +4 more
doaj   +1 more source

The amyloid precursor protein: beyond amyloid.

Molecular neurodegeneration, 2006
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Zheng H., Koo E.H.
openaire   +3 more sources

The Development of an Early Diagnostic Method for Alzheimer’s Disease

Proceedings
Alzheimer’s disease (AD) is the most common form of dementia, characterized by neuronal degeneration and death [...]
Yulia K. Styufliaeva, Andrew A. Zelinsky, Oksana A. Malikova, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Transthyretin in high density lipoproteins: association with apolipoprotein A-I

Journal of Lipid Research, 2000
Previous studies have revealed the presence of transthyretin (TTR) on lipoproteins. To further address this issue, we fractionated plasma lipoproteins from 9 normal individuals, 10 familial amyloidotic polyneuropathy (FAP) patients, and 19 hyperlipidemic
Mónica Mendes Sousa, Lars Berglund, Maria João Saraiva   +2 more
doaj   +1 more source

Night‐to‐night variability in sleep and amyloid beta burden in normal aging

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants
Aurore Jouvencel, Marion Baillet, Marie Meyer, Bixente Dilharreguy, Frederic Lamare, Karine Pérès, Catherine Helmer, Jean‐François Dartigues, Hélène Amieva, Willy Mayo, Gwenaëlle Catheline   +10 more
doaj   +1 more source

Implication of tau propagation on neurodegeneration in Alzheimer’s disease

Frontiers in Neuroscience, 2023
Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression of Alzheimer’s disease (AD). Although it is not well-established what drives or attenuates tau spreading, new studies on human brain using
Daniel Lamontagne-Kam, Anosha Kiran Ulfat, Vincent Hervé, Tra-My Vu, Jonathan Brouillette   +4 more
doaj   +1 more source

Yeast Approach in Amyloidogenic Proteins Study

Proceedings
Self-reproducing protein aggregates of a fibrillar nature (amyloids) are associated with a number of animal and human diseases [...]
Andrew A. Zelinsky, Marina V. Ryabinina, Yury O. Chernoff, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source