Results 31 to 40 of about 547,277 (291)

The amyloid precursor protein: beyond amyloid.

Molecular neurodegeneration, 2006
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Zheng H., Koo E.H.
openaire   +3 more sources

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly [PDF]

, 2008
Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid results in numerous human diseases. Despite an increasing number of proteins and peptide fragments being recognised as amyloidogenic, how these amyloid aggregates ...
Xue, Wei-Feng, Radford, Sheena E., Homans, Steve W.   +2 more
core   +1 more source

β-microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH [PDF]

, 2014
Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of β-microglobulin (βm),
Eric W. Hewitt, Xue, W-F, Beales Paul A., Sheynis, T, Radford, SE, Neil A. Ranson (610030), Sheena E. Radford (197775), Beales, Paul A, Goodchild Sophia C., Thompson, Rebecca, Xue Wei-Feng, Neil A. Ranson, Thompson Rebecca, Sheena E Radford, Sophia C. Goodchild, Sheynis Tania, Eric W Hewitt, Kevin W. Tipping (610028), Radford Sheena E., Tipping Kevin W., Sheena E. Radford, Hewitt, EW, Xue, Wei-Feng, Beales, PA, Radford, Sheena E, Tipping, KW, Sophia C Goodchild, Paul A Beales, Goodchild, SC, Ranson, Neil A, Rebecca Thompson, Wei-Feng Xue (610029), Ranson Neil A., Neil A Ranson, Tipping, Kevin W, Tania Sheynis (610026), Kevin W Tipping, Tania Sheynis, Sheynis, Tania, Wei-Feng Xue, Goodchild, Sophia C, Eric W. Hewitt (197779), Hewitt, Eric W, Hewitt Eric W., Sophia C. Goodchild (283440), Ranson, NA, Rebecca Thompson (610027), Paul A. Beales (435545), Thompson, R, Paul A. Beales   +49 more
core   +1 more source

Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells

Biochemistry and Biophysics Reports
Background: Light chain research is hampered by lack of mammalian cell lines producing human light chains (FLC). Therefore, we used heterohybridoma (HH) technology to produce clones making FLC thereby providing tools to study light chain behavior ...
P. Zhou, X. Ma, S. Scalia, D. Toskic, X. Wu, T. Fogaren, Nancy Coady Lyons, Luis del Pozo-Yauner, R.L. Comenzo   +8 more
doaj   +1 more source

AL Amyloidosis for the Cardiologist and Oncologist

JACC. CardioOncology, 2019
AL amyloidosis results from clonal production of immunoglobulin light chains, most commonly arising from a clonal plasma cell disorder. Once considered a nearly uniformly fatal disease, prognosis has improved markedly over the past 15 years ...
Ronald M. Witteles, MD, Michaela Liedtke, MD   +1 more
doaj   +1 more source

Exploring Biomolecular Self-Assembly with Far-Infrared Radiation

Biomolecules, 2022
Physical engineering technology using far-infrared radiation has been gathering attention in chemical, biological, and material research fields. In particular, the high-power radiation at the terahertz region can give remarkable effects on biological ...
Takayasu Kawasaki, Yuusuke Yamaguchi, Hideaki Kitahara, Akinori Irizawa, Masahiko Tani   +4 more
doaj   +1 more source

Cerebral amyloid angiopathy : new insights from transgenic mice [PDF]

, 2004
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of congophilic material within the walls of small to medium-sized blood vessels of the brain and leptomeninges.
Herzig, Martin C.
core   +1 more source

The Development of an Early Diagnostic Method for Alzheimer’s Disease

Proceedings
Alzheimer’s disease (AD) is the most common form of dementia, characterized by neuronal degeneration and death [...]
Yulia K. Styufliaeva, Andrew A. Zelinsky, Oksana A. Malikova, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Transthyretin in high density lipoproteins: association with apolipoprotein A-I

Journal of Lipid Research, 2000
Previous studies have revealed the presence of transthyretin (TTR) on lipoproteins. To further address this issue, we fractionated plasma lipoproteins from 9 normal individuals, 10 familial amyloidotic polyneuropathy (FAP) patients, and 19 hyperlipidemic
Mónica Mendes Sousa, Lars Berglund, Maria João Saraiva   +2 more
doaj   +1 more source

Night‐to‐night variability in sleep and amyloid beta burden in normal aging

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants
Aurore Jouvencel, Marion Baillet, Marie Meyer, Bixente Dilharreguy, Frederic Lamare, Karine Pérès, Catherine Helmer, Jean‐François Dartigues, Hélène Amieva, Willy Mayo, Gwenaëlle Catheline   +10 more
doaj   +1 more source