Results 31 to 40 of about 504,545 (312)

AL Amyloidosis for the Cardiologist and Oncologist

JACC. CardioOncology, 2019
AL amyloidosis results from clonal production of immunoglobulin light chains, most commonly arising from a clonal plasma cell disorder. Once considered a nearly uniformly fatal disease, prognosis has improved markedly over the past 15 years ...
Ronald M. Witteles, MD, Michaela Liedtke, MD   +1 more
doaj   +1 more source

Exploring Biomolecular Self-Assembly with Far-Infrared Radiation

Biomolecules, 2022
Physical engineering technology using far-infrared radiation has been gathering attention in chemical, biological, and material research fields. In particular, the high-power radiation at the terahertz region can give remarkable effects on biological ...
Takayasu Kawasaki, Yuusuke Yamaguchi, Hideaki Kitahara, Akinori Irizawa, Masahiko Tani   +4 more
doaj   +1 more source

Bacterial Amyloids [PDF]

, 2012
Many bacteria can assemble functional amyloid fibers on their cell surface. The majority of bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface or with another cell. Bacterial amyloids, like all functional amyloids, share structural and biochemical properties with disease-associated eukaryotic ...
Yizhou, Zhou, Luz P, Blanco, Daniel R, Smith, Matthew R, Chapman   +3 more
openaire   +2 more sources

Mitochondrial β-amyloid in Alzheimer's disease

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Conway, SJ, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway   +20 more
core   +1 more source

Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells

Biochemistry and Biophysics Reports
Background: Light chain research is hampered by lack of mammalian cell lines producing human light chains (FLC). Therefore, we used heterohybridoma (HH) technology to produce clones making FLC thereby providing tools to study light chain behavior ...
P. Zhou, X. Ma, S. Scalia, D. Toskic, X. Wu, T. Fogaren, Nancy Coady Lyons, Luis del Pozo-Yauner, R.L. Comenzo   +8 more
doaj   +1 more source

Transthyretin in high density lipoproteins: association with apolipoprotein A-I

Journal of Lipid Research, 2000
Previous studies have revealed the presence of transthyretin (TTR) on lipoproteins. To further address this issue, we fractionated plasma lipoproteins from 9 normal individuals, 10 familial amyloidotic polyneuropathy (FAP) patients, and 19 hyperlipidemic
Mónica Mendes Sousa, Lars Berglund, Maria João Saraiva   +2 more
doaj   +1 more source

Night‐to‐night variability in sleep and amyloid beta burden in normal aging

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants
Aurore Jouvencel, Marion Baillet, Marie Meyer, Bixente Dilharreguy, Frederic Lamare, Karine Pérès, Catherine Helmer, Jean‐François Dartigues, Hélène Amieva, Willy Mayo, Gwenaëlle Catheline   +10 more
doaj   +1 more source

Implication of tau propagation on neurodegeneration in Alzheimer’s disease

Frontiers in Neuroscience, 2023
Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression of Alzheimer’s disease (AD). Although it is not well-established what drives or attenuates tau spreading, new studies on human brain using
Daniel Lamontagne-Kam, Anosha Kiran Ulfat, Vincent Hervé, Tra-My Vu, Jonathan Brouillette   +4 more
doaj   +1 more source

The amyloid precursor protein: beyond amyloid.

Molecular neurodegeneration, 2006
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Zheng H., Koo E.H.
openaire   +3 more sources

Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia

, 2001
Familial British dementia (FBD), pathologically characterized by cerebral amyloid angiopathy (CAA), amyloid plaques, and neurofibrillary degeneration, is associated with a stop codon mutation in the BRI gene resulting in the production of an ...
Tammaryn Lashley, Ghiso, J, Vidal, R, Ayling, H., Gibb, G, Anderton, B H, Hilary Ayling, Rostagno, A., Anderton, B.H., Plant, G., Janice L. Holton, Tamas Revesz, Revesz, T, Martinian, L, Henry Houlden, Ruben Vidal, Nicholas W. Wood, Lashley, T, Revesz, T., Frangione, B., Jorge Ghiso, Ayling, H, Holton, J.L., Christopher J. Guerin, Houlden, H, Plant, G, Holton, J L, Gordon Plant, Rostagno, A, Lashle, T., Gibb, G., Lillian Martinian, Ghiso, J., Graham Gibb, Martinian, L., Brian H. Anderton, Agueda Rostagno, Houlden, H., Wood, N.W., Frangione, B, Vidal, R., Guerin, C J, Wood, N W, Guerin, C.J., Blas Frangione   +44 more
core   +1 more source