Results 1 to 10 of about 202,263 (297)
Nature Reviews Disease Primers, 2021 Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic neurodegenerative disease that causes an amnestic cognitive impairment in its prototypical presentation and non-amnestic cognitive impairment in its less common variants.
David S. Knopman +7 more
openaire +4 more sources
BMJ Open, 2022 Objective Preventing Alzheimer’s dementia (AD) fundamentally equates to delaying onset. Thus, we quantified associations of modifiable, psychosocial risk factors to years of delayed onset of dementia.Design Two prospective cohorts (n=2860) with negative ...
Robert S Wilson +4 more
doaj +1 more source
Brain Sciences, 2021 Objective: The aim of the current study was to estimate the discriminant potential and validity of the Digit Symbol Substitution Test (DSST) of the WAIS-R in the Greek elderly population meeting criteria for subjective cognitive decline (SCD), mild ...
Marianna Tsatali +8 more
doaj +1 more source
Network: Computation in Neural Systems, 2011 Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in biomedicine--neurodegeneration. Eponymic diseases of the nervous system such as Alzheimer's, Parkinson's, and Huntington's diseases that were long characterized by mechanistic ignorance have yielded striking progress ...
Adam, Gazzaley, Scott A, Small
+8 more sources
Plasma microRNAs as potential biomarkers in early Alzheimer disease expression
Scientific Reports, 2022 The microRNAs (miRNAs) are potential biomarkers for complex pathologies due to their involvement in the regulation of several pathways. Alzheimer Disease (AD) requires new biomarkers in minimally invasive samples that allow an early diagnosis. The aim of
Carmen Peña-Bautista +7 more
doaj +1 more source
Brain Sciences, 2022 Background: It can be easily inferred that dementia caregivers were severely affected by the general home confinement, or ‘lockdown’, due to their caregiving roles.
Evdokia Nikolaidou +6 more
doaj +1 more source
Journal of Neurology, Neurosurgery & Psychiatry, 2000 Use of valid diagnostic criteria is extremely important in the recognition of Alzheimer's disease (AD). Patients with mild to moderate Alzheimer's disease should be started on a cholinesterase inhibitor and possibly anti-inflammatory agents, antioxidants (vitamin E or selegiline), and estrogen replacement therapy (for postmenopausal women).
, Schachter, , Davis
+8 more sources
Biosensors, 2021 Presenilin (PS)/γ-secretase is an aspartyl protease that processes a wide range of transmembrane proteins such as the amyloid precursor protein (APP) and Notch1, playing essential roles in normal biological events and diseases.
Mei C. Q. Houser +5 more
doaj +1 more source
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018 Alzheimer's disease (AD) is a serious medical and social problem of our time, while remaining the most common cause of dementia in the elderly. The leading symptom in the clinical picture of the disease is a progressive loss of memory with further development of behavioral disorders.
O A, Kicherova, L I, Reikhert
openaire +4 more sources
GPS driving: a digital biomarker for preclinical Alzheimer disease
Alzheimer’s Research & Therapy, 2021 Background Alzheimer disease (AD) is the most common cause of dementia. Preclinical AD is the period during which early AD brain changes are present but cognitive symptoms have not yet manifest.
Sayeh Bayat +6 more
doaj +1 more source