Results 11 to 20 of about 362,575 (339)
Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
Molecular Neurodegeneration, 2023 DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways.
Yige Huang +4 more
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Analyses of off‐label use of acetylcholinesterase inhibitors (AChEIs) in mild cognitive impairment (MCI) has produced mixed results. Post hoc analyses of observational cohorts, such as the Alzheimer's Disease Neuroimaging Initiative (ADNI ...
Eddie Stage +8 more
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Alzheimer’s Research & Therapy, 2021 Background Comprehensive testing of cognitive functioning is standard practice in studies of Alzheimer disease (AD). Short-form tests like the Montreal Cognitive Assessment (MoCA) use a “sampling” of measures, administering key items in a shortened ...
Jason Hassenstab +7 more
doaj +1 more source
The Importance of Advancing Research on Aging and Driving
Geriatrics, 2021 Between 2009 and 2018, the number of older adults (i [...]
Samantha A. Murphy +2 more
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Pharmaceutics, 2023 (1) Background: The role of antihypertensives in Alzheimer’s Disease (AD) prevention is controversial. This case-control study aims to assess whether antihypertensive medication has a protective role by studying its association with amyloid and tau ...
Gemma García-Lluch +5 more
doaj +1 more source
TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease
Acta Neuropathologica Communications, 2018 TDP-43 pathology was investigated in the anterior temporal pole cortex (ATPC) and orbital frontal cortex (OFC), regions often degenerated in frontotemporal lobar degenerations (FTLD), in aging and Alzheimer’s disease (AD).
Sukriti Nag +5 more
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Nature Reviews Disease Primers, 2021 Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic neurodegenerative disease that causes an amnestic cognitive impairment in its prototypical presentation and non-amnestic cognitive impairment in its less common variants.
David S. Knopman +7 more
openaire +2 more sources
A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells
Sensors, 2020 Presenilin (PS)/γ-secretase plays a pivotal role in essential cellular events via proteolytic processing of transmembrane proteins that include APP and Notch receptors. However, how PS/γ-secretase activity is spatiotemporally regulated by other molecular
Mei CQ Houser +6 more
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In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons
Biosensors, 2022 Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture
Alec K. McKendell +5 more
doaj +1 more source
Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET
Acta Neuropathologica Communications, 2018 This study aimed to determine the pattern of [18F]flortaucipir uptake in individuals affected by Gerstmann-Sträussler-Scheinker disease (GSS) associated with the PRNP F198S mutation.
Shannon L. Risacher +11 more
doaj +1 more source