Results 1 to 10 of about 339,510 (279)

Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non‐demented adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction We investigated whether insulin resistance (IR) was associated with longitudinal age‐related change in cognition and biomarkers of Alzheimer's disease (AD) pathology and neurodegeneration in middle‐aged and older adults who were non‐demented
Gilda E. Ennis, Rebecca L. Koscik, Yue Ma, Erin M. Jonaitis, Carol A. Van Hulle, Tobey J. Betthauser, Allison M. Randall, Nathaniel Chin, Corinne D. Engelman, Rozalyn Anderson, Ivonne Suridjan, Gwendlyn Kollmorgen, Bradley T. Christian, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B. Bendlin   +18 more
doaj   +1 more source

Association between BrainAGE and Alzheimer's disease biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION The brain age gap estimation (BrainAGE) method uses a machine learning model to generate an age estimate from structural magnetic resonance imaging (MRI) scans. The goal was to study the association of brain age with Alzheimer's disease (AD)
Yousaf Abughofah, Rachael Deardorff, Aaron Vosmeier, Savannah Hottle, Jeffrey L. Dage, Desarae Dempsey, Liana G. Apostolova, Jared Brosch, David Clark, Martin Farlow, Tatiana Foroud, Sujuan Gao, Sophia Wang, Henrik Zetterberg, Kaj Blennow, Andrew J. Saykin, Shannon L. Risacher   +16 more
doaj   +1 more source

Characterizing biomarker features of cognitively normal individuals with ventriculomegaly

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear. Methods We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and ...
Xiaofeng Li, Maowen Ba, Kok Pin Ng, Sulantha Mathotaarachchi, Tharick A. Pascoal, Pedro Rosa‐Neto, Serge Gauthier, Alzheimer's Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

Cognitive decline across five cognitive batteries: Sample size implications for clinical trials

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION We evaluated the statistical power for a theoretical randomized trial of anti‐amyloid treatment in preclinical Alzheimer's Disease across five cognitive composites in preclinical Alzheimer's Disease across five cognitive composites ...
Andrea R. Zammit, Ana W. Capuano, Lisa L. Barnes, Julie A. Schneider, Reisa A. Sperling, David A. Bennett, Francine Grodstein   +6 more
doaj   +1 more source

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Neurobiology of Disease, 2013
Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been suggested that modulation of neuronal activity may alter Aβ production in the brain.
Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M. Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T. Hyman, Oksana Berezovska   +9 more
doaj   +1 more source

Associations of renin–angiotensin system inhibitor use with brain insulin signaling and neuropathology

Annals of Clinical and Translational Neurology
Objective To examine the associations of renin–angiotensin system (RAS) inhibitor use with postmortem brain insulin signaling and neuropathology. Methods Among Religious Orders Study participants, 150 deceased and autopsied older individuals (75 with ...
Han Tong, Ana W. Capuano, Rupal I. Mehta, Ajay Sood, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis   +7 more
doaj   +1 more source

Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Abnormal brain amyloid beta (Aβ) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown whether the assessment of the topographical distribution of Aβ
Tharick A. Pascoal, Joseph Therriault, Sulantha Mathotaarachchi, Min Su Kang, Monica Shin, Andrea L. Benedet, Mira Chamoun, Cecile Tissot, Firoza Lussier, Sara Mohaddes, Jean‐Paul Soucy, Gassan Massarweh, Serge Gauthier, Pedro Rosa‐Neto, for the Alzheimer's Disease Neuroimaging Initiative   +14 more
doaj   +1 more source

Linkage analysis of multiplex Caribbean Hispanic families loaded for unexplained early‐onset cases identifies novel Alzheimer's disease loci

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Less than 10% of early‐onset Alzheimer's disease (EOAD) is explained by known mutations. Methods We conducted genetic linkage analysis of 68 well‐phenotyped Caribbean Hispanic families without clear inheritance patterns or mutations in APP ...
Rong Cheng, Min Tang, Izri Martinez, Temitope Ayodele, Penelope Baez, Dolly Reyes‐Dumeyer, Rafael Lantigua, Martin Medrano, Ivonne Jimenez‐Velazquez, Joseph H. Lee, Gary W. Beecham, Christiane Reitz   +11 more
doaj   +1 more source

A service‐oriented approach to clinical trial recruitment for dementia and brain health: Methods and case examples of MyAlliance for Brain Health

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Recruitment of sufficient and diverse participants into clinical research for Alzheimer's disease and related dementias remains a formidable challenge.
Eric D. Vidoni, Emma Swinford, Kelli Barton, Jaime Perales‐Puchalt, C. Michelle Niedens, Tina Lewandowski, Tiffany Schwasinger‐Schmidt, Jill Peltzer, JoEllen Wurth, Jannette Berkley‐Patton, Ryan A. Townley, W. Todd Moore, Ashley R. Shaw, Mickeal N. Key, Erica Andrade, Melissa Robinson, Susan Sprague, Aiden Bondurant, Debra Brook, Jennifer Freund, Jeffrey M. Burns   +20 more
doaj   +1 more source

Thioredoxin‐80 is a product of alpha‐secretase cleavage that inhibits amyloid‐beta aggregation and is decreased in Alzheimer's disease brain

EMBO Molecular Medicine, 2012
Thioredoxin‐1 (Trx1) is an endogenous dithiol reductant and antioxidant that was shown to be decreased in Alzheimer's disease (AD) neurons. A truncated form of Trx1, thioredoxin 80 (Trx80), was reported to be secreted from monocytes having cytokine ...
Francisco Gil‐Bea, Susanne Akterin, Torbjörn Persson, Laura Mateos, Anna Sandebring, Javier Avila‐Cariño, Angel Gutierrez‐Rodriguez, Erik Sundström, Arne Holmgren, Bengt Winblad, Angel Cedazo‐Minguez   +10 more
doaj   +1 more source