Relation of neuropathology with cognitive decline among older persons without dementia
Frontiers in Aging Neuroscience, 2013 Objective: Although it is now widely accepted that dementia has a long preclinical phase during which neuropathology accumulates and cognition declines, little is known about the relation of neuropathology with the longitudinal rate of change in ...
Patricia eBoyle +4 more
doaj +1 more source
ARIA in patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer's disease
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023 INTRODUCTION Lecanemab is a humanized immunoglobulin G1 (IgG1) monoclonal antibody that preferentially targets soluble aggregated Aβ species (protofibrils) with activity at amyloid plaques.
Lawrence S. Honig +8 more
doaj +1 more source
Why musical memory can be preserved in advanced Alzheimer's disease [PDF]
, 2015 Musical memory is relatively preserved in Alzheimer's disease and other dementias. In a 7 Tesla functional MRI study employing multi-voxel pattern analysis, Jacobsen et al.
Chételat, Gael +4 more
core +2 more sources
Factors related to the quality of life in family carers of people with dementia: a meta- analysis [PDF]
, 2021 Objectives: This meta-analysis aimed to (1) quantitatively synthesize evidence of factors related to the quality of life (QoL) of family carers of people with dementia and (2) explore moderating factors that may influence the strength of the relationship
Contreras, Milena +2 more
core +3 more sources
Risk Aversion is Associated with Decision Making among Community-Based Older Persons
Frontiers in Psychology, 2012 Background: Risk aversion is associated with many important decisions among younger and middle aged persons, but the association of risk aversion and decision making has not been well studied among older persons who face some of the most significant ...
Patricia eBoyle +3 more
doaj +1 more source
Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]
, 2018 IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat +7 more
core +1 more source
Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative. [PDF]
, 2018 IntroductionWe characterize long-term disease dynamics from cognitively healthy to dementia using data from the Alzheimer's Disease Neuroimaging Initiative.MethodsWe apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker ...
Aisen, Paul S +5 more
core +1 more source
The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease. [PDF]
, 2019 IntroductionClinical trials on preclinical Alzheimer's disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more ...
Aisen, Paul S +4 more
core +1 more source
Applications of neuroimaging to disease-modification trials in Alzheimer's disease. [PDF]
, 2009 Critical to development of new therapies for Alzheimer's disease (AD) is the ability to detect clinical or pathological change over time. Clinical outcome measures typically used in therapeutic trials have unfortunately proven to be relatively variable ...
Aisen, Paul S +5 more
core +2 more sources
Progression of extrapyramidal signs in Alzheimer's disease. clinical and neuropathological correlates [PDF]
, 2015 Extrapyramidal signs (EPS) are frequent in Alzheimer's disease (AD) and core manifestation of related diseases, i.e., dementia with Lewy bodies and Parkinson's disease; furthermore, Lewy bodies and AD-type pathology occur in all three ...
Bruno, Giuseppe +4 more
core +1 more source