Results 11 to 20 of about 5,103,561 (270)

Alzheimer disease [PDF]

Nature Reviews Disease Primers, 2021
Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic neurodegenerative disease that causes an amnestic cognitive impairment in its prototypical presentation and non-amnestic cognitive impairment in its less common variants.
David S. Knopman, Helene Amieva, Ronald C. Petersen, Gäel Chételat, David M. Holtzman, Bradley T. Hyman, Ralph A. Nixon, David T. Jones   +7 more
openaire   +4 more sources

Alzheimer’s disease [PDF]

Current Biology, 2018
The German psychiatrist and neuropathologist Alois Alzheimer was fascinated by the symptoms of Auguste D., a 50-year-old woman admitted to the Frankfurt Psychiatric Hospital in 1901 who suffered from memory disturbances, paranoia and progressive confusion. After her death and autopsy, Alzheimer described histological alterations in her brain that later
Grøntvedt, G., Navarro Schröder, T., Sando, S., White, L., Bråthen, G., Doeller, C. ; https://orcid.org/0000-0003-4120-4600   +5 more
openaire   +5 more sources

Elucidating the role of DEPTOR in Alzheimer's disease [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.The mammalian or mechanistic target of rapamycin (mTOR) is a Ser/Thr protein kinase that, in response to nutrient stimulation, regulates cellular growth, proliferation ...
Karteris, E, Zachariades, E, Rogers-Broadway, K-R, Davies, J   +3 more
core   +7 more sources

Alzheimer’s disease [PDF]

Network: Computation in Neural Systems, 2011
Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in biomedicine--neurodegeneration. Eponymic diseases of the nervous system such as Alzheimer's, Parkinson's, and Huntington's diseases that were long characterized by mechanistic ignorance have yielded striking progress ...
Adam, Gazzaley, Scott A, Small
  +8 more sources

A data-driven examination of apathy and depressive symptoms in dementia with independent replication [PDF]

, 2023
Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or ...
Schuff, N, Stern, Y, Reinwald, LT, Carroll, M, Ward, C, Ballard, C, Jagust, W, Mathis, C, Schneider, LS, Teodoro, L, Meyer, JV, Gessert, D, Harvey, D, Dolen, S, Mintun, MA, Weiner, M, Carter, R, Leon, S, Ances, B, Householder, E, Rountree, S, Gunter, J, Brewer, J, Toga, AW, Schneider, S, Landau, S, Creese, B, Bell, KL, Aisen, P, Shaw, LM, Senjem, M, Jack, CR, Melendez-Torres, GJ, Sather, T, Nho, K, Shen, L, Dang, M, Borowski, B, DeCArli, C, Molchan, S, Beckett, L, Frank, R, Liu, E, Foroud, TM, Cairns, NJ, Korecka, M, Oliver, A, Lord, JL, Koeppe, RA, Knopman, D, Fleisher, A, Walter, S, Vasconcelos Da Silva, M, Fox, N, Albers, CS, Beccera, M, Vemuri, P, Lee, V, Lind, B, Green, RC, Figurski, M, Kim, S, Snyder, PJ, Johnson, K, Heidebrink, JL, Pawluczyk, S, Thomas, RG, Foster, N, Jones, D, Honig, LS, Petersen, R, Bernstein, M, Chowdhury, M, Spann, BM, Kaye, J, Marson, D, Montine, T, Kantarci, K, Trojanowki, JQ, Kachaturian, Z, Testad, I, Reiman, EM, Chen, K, Mason, SS, Crawford, K, Van der Swag, H, Donohue, M, Jiminez, G, Morris, J, Doody, RS, Potkin, S, Kelley, F, Ismail, Z, Saykin, AJ, Quinn, J, Thompson, P, Neu, S   +96 more
core   +1 more source

Alzheimer's Disease [PDF]

Neurobiology of Disease, 2000
Use of valid diagnostic criteria is extremely important in the recognition of Alzheimer's disease (AD). Patients with mild to moderate Alzheimer's disease should be started on a cholinesterase inhibitor and possibly anti-inflammatory agents, antioxidants (vitamin E or selegiline), and estrogen replacement therapy (for postmenopausal women).
, Schachter, , Davis
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Barriers and facilitators to participating in Alzheimer's disease biomarker research in black and white older adults

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023
Introduction The study examined Black and White prospective participants’ views of barriers to and facilitators of participation in Alzheimer's disease (AD) biomarker research.
Johanne Eliacin, Angelina J. Polsinelli, Francine Epperson, Sujuan Gao, Sarah Van Heiden, Glenda Westmoreland, Ralph Richards, Mollie Richards, Christopher Campbell, Hugh Hendrie, Shannon L. Risacher, Andrew J. Saykin, Sophia Wang   +12 more
doaj   +1 more source

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

iScience, 2021
Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer ...
Ana Claudia Amaral, Beatriz G. Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P. Frosch, Susanne Wegmann, Teresa Gomez-Isla   +15 more
doaj   +1 more source

Alzheimer's Disease Beyond Amyloid: Lessons From Atherosclerosis. [PDF]

Ann Clin Transl Neurol
Annals of Clinical and Translational Neurology, EarlyView.
Ciaccio M, Agnello L.
europepmc   +2 more sources

Stability and change in acculturation‐related characteristics in older Latinos: Implications for culturally compatible ADRD research

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023
Introduction Acculturation‐related characteristics, that is, factors directly connected to culture and familial relationships, are associated with engaged research participation within Latino communities.
Melissa Lamar, Crystal M. Glover, Ana W. Capuano, Robert S. Wilson, Debra A. Fleischman, David A. Bennett, David X. Marquez   +6 more
doaj   +1 more source