Results 1 to 10 of about 1,078,221 (259)

Evaluation of cognitive function in the Dog Aging Project: associations with baseline canine characteristics

Scientific Reports, 2022
Canine cognitive dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously in relatively small cohorts of dogs using multiple different rating scales.
Sarah Yarborough, Annette Fitzpatrick, Stephen M. Schwartz, Dog Aging Project Consortium   +3 more
doaj   +1 more source

Implementation and review of the care ecosystem in an integrated healthcare system

BMC Geriatrics, 2023
Background and objectives The University of California, San Francisco Memory and Aging Center (UCSF-MAC) led the development and tested a collaborative care model delivered by lay care team navigators (CTNs) with support from a multidisciplinary team ...
Michael H. Rosenbloom, Bhavani Kashyap, Ana Diaz-Ochoa, Jan Karrmann, Aleta Svitak, Jennifer Finstad, Ann Brombach, Ann Sprandel, Leah Hanson, Sarah Dulaney, Katherine Possin   +10 more
doaj   +1 more source

Coenzyme A binding sites induce proximal acylation across protein families

Scientific Reports, 2023
Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated ...
Chris Carrico, Andrew Cruz, Marius Walter, Jesse Meyer, Cameron Wehrfritz, Samah Shah, Lei Wei, Birgit Schilling, Eric Verdin   +8 more
doaj   +1 more source

Ageing and vascular ageing [PDF]

Postgraduate Medical Journal, 2006
Abstract There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance.
B, Jani, C, Rajkumar
openaire   +2 more sources

Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2023
Background Atrial fibrillation (AF) is a strong risk factor for Alzheimer’s disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated.
Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Hayato Odagiri, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki   +8 more
doaj   +1 more source

Expert consensus on neuroimaging diagnosis of dementia and cognitive impairment (2023) [PDF]

Zhenduanxue lilun yu shijian
For patients with cognitive impairment as the main clinical manifestation, structural MRI (or CT instead) should be performed first to clarify intracranial lesions and brain atrophy.
Aging and Cognitive Impairment Branch of Shanghai Society of Aging and Degenerative Diseases
doaj   +1 more source

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Nature Communications, 2021
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen, Travis B. Lear, John W. Evankovich, Mads B. Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood, Ferhan Tuncer, Jie Liu, Michael M. Myerburg, John F. McDyer, Yuan Liu, Toren Finkel, Bill B. Chen   +16 more
doaj   +1 more source

To age or not to age

Proceedings of the Royal Society of London. Series B: Biological Sciences, 2004
According to the antagonistic pleiotropy theory of ageing, natural selection has favoured genes conferring short-term benefits to the organism at the cost of deterioration in later life. The 'disposable soma' theory expresses this as a life-history strategy in which somatic maintenance is below the level required to prevent ageing, thus enabling higher
Peter D, Sozou, Robert M, Seymour
openaire   +3 more sources

MARK-AGE biomarkers of ageing [PDF]

Mechanisms of Ageing and Development, 2015
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age.
Bürkle, Alexander, Moreno Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H. J., Toussaint, Olivier, Grubeck Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, FRANCESCHI, CLAUDIO, CAPRI, MIRIAM, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko, Aspinall, Richard   +29 more
openaire   +7 more sources

Effects of repetitive Transcranial Magnetic Stimulation in aged rats depend on pre-treatment cognitive status: Toward individualized intervention for successful cognitive aging

Brain Stimulation, 2021
Background: Repetitive Transcranial Magnetic Stimulation (rTMS) has shown initial promise in combating age-related cognitive decline and dementia. The nature and severity of cognitive aging, however, varies markedly between individuals.
Marina Weiler, Perla Moreno-Castilla, Hannah M. Starnes, Edward L.R. Melendez, Kevin C. Stieger, Jeffrey M. Long, Peter R. Rapp   +6 more
doaj   +1 more source