Results 11 to 20 of about 2,842,411 (305)

Opportunities for organoids as new models of aging. [PDF]

, 2018
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica, Arora, Astashkina, Auger, Aw, Azpurua, Barbero, Barkauskas, Barkauskas, Barker, Bartfeld, Behjati, Belmin, Ben-Ze’ev, Bhumiratana, Blau, Blokzijl, Brack, Broutier, Busuttil, Caron, Caughey, Cerchiari, Chambers, Chang, Chaudhuri, Choi, Cornacchia, Crabb, Danahay, Dekkers, Dos Santos, Dye, Eiraku, Elahy, Engevik, Freedman, Gao, Garbe, Gjorevski, Greider, Gullapalli, Hannum, Hansen, Hegab, Heintz, Hibiya, Hohwieler, Horvath, Htwe, Huch, Huch, Jennifer L. Hu, Jones, Jung, Karthaus, Kolesky, Koo, Kwong, Lang, Lee, Lee, Levental, Li, Li, Lindahl, Linnemann, Liu, Lozito, Lyons, López-Otín, L’Heureux, Madden, Marciniak, Mark A. LaBarge, Matsui, Mattison, McElwee, Meerwaldt, Mertens, Messner, Michael E. Todhunter, Miller, Moore, Moore, Morizane, Murrow, Myers, Nalapareddy, Nasto, Nelson, Nevalainen, Nguyen-Ngoc, Nicholas, Noguchi, Ootani, O’Brien, Pageon, Pang, Parrinello, Pauli, Phillip, Plaks, Pribluda, Qian, Raja, Rangarajan, Rodriguez-Teja, Ruan, Sancar, Sato, Schütte, Seok, Simian, Singh, Squires, Stampfer, Stearns-Reider, Stojadinovic, Sun, Takasato, Takebe, Tan, Tanos, Toda, Todhunter, Turco, Tzatzalos, van Vliet, Vanhooren, Vernetti, Verzijl, Villadsen, Villeda, Voytik-Harbin, Watson, Williams, Wilson, Workman, Wu, Wylie, Xiang, Yilmaz, Zev J. Gartner, Zhang, Zhang   +145 more
core   +2 more sources

Correction for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium

BMC Medical Research Methodology, 2018
Background Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery.
Annie M. Racine, Yun Gou, Tamara G. Fong, Edward R. Marcantonio, Eva M. Schmitt, Thomas G. Travison, Sharon K. Inouye, Richard N. Jones   +7 more
doaj   +1 more source

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease [PDF]

, 2013
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as ...
Barclay, Stephen, McGuinness, Dagmara, McLauchlan, John, Mills, Peter R., Patel, Arvind H., Robinson, Mark W., Shiels, Paul G., Swann, Rachael   +7 more
core   +2 more sources

Aging Scaled Brownian Motion [PDF]

, 2015
Scaled Brownian motion (SBM) is widely used to model anomalous diffusion of passive tracers in complex and biological systems. It is a highly non-stationary process governed by the Langevin equation for Brownian motion, however, with a power-law time ...
Chechkin, A. V., Jafari, G. R., Metzler, R., Safdari, H.   +3 more
core   +3 more sources

Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome

Drugs in R&D, 2020
Background Individuals with Down syndrome are likely to develop clinical and neuropathological brain changes resembling Alzheimer’s disease dementia by the ages of 35–40 years.
Michael Rosenbloom, Terry Barclay, Justin Johnsen, Lauren Erickson, Aleta Svitak, Maria Pyle, William Frey, Leah R. Hanson   +7 more
doaj   +1 more source

Ageing and vascular ageing [PDF]

Postgraduate Medical Journal, 2006
Abstract There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance.
B, Jani, C, Rajkumar
openaire   +2 more sources

MARK-AGE biomarkers of ageing [PDF]

Mechanisms of Ageing and Development, 2015
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age.
Bürkle, Alexander, Moreno Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H. J., Toussaint, Olivier, Grubeck Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, FRANCESCHI, CLAUDIO, CAPRI, MIRIAM, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko, Aspinall, Richard   +29 more
openaire   +6 more sources

First passage statistics for aging diffusion in annealed and quenched disorder [PDF]

, 2014
Aging, the dependence of the dynamics of a physical process on the time $t_a$ since its original preparation, is observed in systems ranging from the motion of charge carriers in amorphous semiconductors over the blinking dynamics of quantum dots to the ...
Godec, Aljaz, Kruesemann, Henning, Metzler, Ralf   +2 more
core   +3 more sources

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]‐PBR28 positron‐emission tomography imaging.
Tammy T. Hshieh, Sarinnapha M. Vasunilashorn, Madeline L. D'Aquila, Steven E. Arnold, Bradford C. Dickerson, Tamara G. Fong, Richard N. Jones, Edward R. Marcantonio, Eva M. Schmitt, Guoquan Xu, Yun Gou, Fan Chen, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha R. Abdeen, Jeffrey K. Lange, Brandon E. Earp, Alexandra Touroutoglou, Becky C. Carlyle, Pia Kivisakk‐Webb, Thomas G. Travison, Simon T. Dillon, Towia A. Libermann, Sharon K. Inouye, RISE Study Group, Sharon K. Inouye, Steven Arnold, Bradford Dickerson, Tamara Fong, Richard Jones, Towia A. Libermann, Edward R. Marcantonio, Thomas Travison, Becky C. Carlyle, Michele Cavallari, Simon T. Dillon, Jacob Hooker, Tammy Hshieh, Savannah Kandigian, Pia Kivisakk‐Webb, Long Ngo, Hasan Otu, Eva M. Schmitt, Alexandra Touroutoglou, Bianca Trombetta, Sarinnapha Vasunilashorn, Ayesha Abdeen, Douglas Ayres, Brandon Earp, Jeffrey Lange, Gregory Brick, Antonia Chen, Robert Davis, Jacob Drew, Richard Iorio, Fulton Kornack, Michael Weaver, Anthony Webber, Richard Wilk, Lisa Kunze, David Shaff, Kamen Vlassakov, Brett Armstrong, Angelee Banda, Sylvie Bertrand, Madeline D'Aquila, Jacqueline Gallagher, Baileigh Hightower, Shannon Malloy, Jacqueline Nee, Chloe Nobuhara, Abigail Overstreet, Annie Racine, David Urick, Guoquan Xu, Grae Arabasz, Michael Brickhouse, Regan Butterfield, Shirley Hsu, Sara Makaretz, Judit Sore, Fan Chen, Yun Gou, Douglas Tommet, Sabrina Carretie, Ted Gruen, Katherine Tasker   +86 more
doaj   +1 more source

The role of glyoxalases for sugar stress and aging, with relevance for dyskinesia, anxiety, dementia and Parkinson's disease [PDF]

, 2011
Commentary on: Scheckhuber CQ et al. Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan. Aging.
Auburger, Georg, Kurz, Alexander
core   +1 more source