Results 31 to 40 of about 2,842,411 (305)

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARKAGE Study [PDF]

, 2016
Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in ...
Bacalini, Maria Giulia, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Ciccarone, Fabio, Dollé, Martijn E.T., Franceschi, Claudio, Gonos, Efstathios S, Grune, Tilman, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno-Villanueva, María, Reale, Anna, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Valentini, Elisabetta, Zampieri, Michele   +24 more
core   +6 more sources

Correlation between Sub-Tg relaxation processes and mechanical behavior for different hydrothermal ageing conditions in epoxy assemblies [PDF]

, 2010
The aim of this study is to understand aging phenomena by monitoring physical parameters after real and simulated aging experiments. This study focuses on aluminum-epoxy assemblies, which are commonly used on spacecraft structures.
Apicella, Bellenger, Bershtein, Boye, Cognard, Colombini, Comrie, Dodiuk, Gupta, Havriliak, Havriliak, Hedvig, Luo, Maggana, Mijovic, Moy, Nogueira, Ochi, Pangrle   +18 more
core   +2 more sources

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

A role for Fis1 in dendritic development

Scientific Reports
Mitochondrial ATP production and calcium handling are critical for metabolic regulation and neurotransmission. Thus, the formation and maintenance of the mitochondrial network is a critical component of neuronal health. Cortical pyramidal neurons contain
Klaudia Strucinska, Parker Kneis, Travis Pennington, Katarzyna Cizio, Patrycja Szybowska, Abigail Morgan, Joshua Weertman, Tommy L. Lewis   +7 more
doaj   +1 more source

The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls

BMC Geriatrics, 2018
Background Peripheral sensory loss is considered one of many risk factors for gait impairments and falls in older adults, yet no prospective studies have examined changes in touch sensation in the foot over time and their relationship to mobility and ...
Lewis A. Lipsitz, Brad Manor, Daniel Habtemariam, Ikechukwu Iloputaife, Junhong Zhou, Thomas G. Travison   +5 more
doaj   +1 more source

The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]

, 2020
Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core   +1 more source

Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]

, 2018
BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina, Chiappini, Elena, Dalzini, Annalisa, De Rossi, Anita, Galli, Luisa, Giaquinto, Carlo, Petrara, Maria Raffaella   +6 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

The Summit on Creativity and Aging in America [PDF]

, 2016
This report looks at how the federal government can leverage the arts to foster healthy aging and inclusive design for this growing population. This white paper features recommendations from the May 2015 Summit on Creativity and Aging in America, a ...
Ace Everett, Gay Hanna, Janice Blanchard, Judith-Kate Friedman, Judy Rollins, Linda Noelker, Paula Cleggett, Tobi Abramson   +7 more
core  

Chemical aging of large-scale randomly rough frictional contacts

, 2018
It has been shown that contact aging due to chemical reactions in single asperity contacts can have a significant effect on friction. However, it is currently unknown how chemically-induced contact aging of friction depends on roughness that is typically
Li, Zhuohan, Pastewka, Lars, Szlufarska, Izabela   +2 more
core   +1 more source