Results 21 to 30 of about 340,510 (279)

Accelerating diversity in Alzheimer's disease research by partnering with a community advisory board

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023
Introduction Community advisory boards (CABs) and researcher partnerships present a promising opportunity to accelerate enrollment of underrepresented groups (URGs).
Alex Pena‐Garcia, Ralph Richards, Mollie Richards, Christopher Campbell, Hank Mosley, Joseph Asper, Johanne Eliacin, Angelina Polsinelli, Liana Apostolova, Hugh Hendrie, Andrew Tackett, Caprice Elliott, Sarah Van Heiden, Sujuan Gao, Andrew Saykin, Sophia Wang, IADRC CAB   +16 more
doaj   +1 more source

Presumed small vessel disease, imaging and cognition markers in the Alzheimer's Disease Neuroimaging Initiative [PDF]

, 2021
MRI-derived features of presumed cerebral small vessel disease are frequently found in Alzheimer's disease. Influences of such markers on disease-progression measures are poorly understood.
Alzheimer's Disease Neuroimaging Initiative
core  

Association of Heel Bone Mineral Density With Incident Disability and Mortality in Community‐Dwelling Older Adults

JBMR Plus, 2020
Age‐related bone loss is common in older adults. However, the association of low bone mass with incident disability and mortality is not well established.
Ryan D Ross, Raj C Shah, Sue E Leurgans, Aron S Buchman, David A Bennett   +4 more
doaj   +1 more source

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. [PDF]

, 2010
The unparalleled collection of clinical data and biomaterials within the EHDN's REGISTRY can expedite the search for disease modifiers (genetic and environmental) of age at onset and disease progression that could be harnessed for the development of ...
Handley, Olivia J, Landwehrmeyer, G Bernhard, Aileen K Ho, Bisson, Jonathan Ian, Schwenke C, David Craufurd, Dunnett, Stephen B., Handley, Olivia, Investigators of the European Huntington's Disease Network, The, DI MARIA, EMILIO, Craufurd D, Dunnett, SB, Carsten Schwenke, the investigators of the European Huntington's Disease Network, Craufurd, David, Edward Wild, Landwehrmeyer, GB, Busse, Monica, Rosser, Anne Elizabeth, Olivia J Handley, Romano Silvia., Tabrizi SJ, Ho, Aileen K., Wild, E, Landwehrmeyer GB, Craufurd, D, Tabrizi, SJ, Tabrizi, Sarah J., Handley, OJ, Rickards, Hugh, Dunnett, Stephen, Ho, Aileen K, Orth, Michael, Ho, AK, Wild, Edward, Stephen B. Dunnett, Sarah J Tabrizi, Wild, EJ, Landwehrmeyer, G. Bernhard, Naji, Jenny, Landwehrmeyer, G. Bernhard, Wild E, Investigators of the European Huntington's Disease Network, Handley, Olivia J., Orth, M, Ellison-Rose, Lynda, Tabrizi, Sarah J, Price, Kathleen, Ho AK, ABBRUZZESE, GIOVANNI, Schwenke, C, Ho, A, Orth M, Handley OJ, Schwenke, Carsten, Dunnett SB, Dunnett, Stephen B, Michael Orth, G. Bernhard Landwehrmeyer   +59 more
core   +1 more source

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
Silvia Cianci, ROMANO, ADELE, Romano, A, M. r. Elphick, Gianluigi Vendemiale, Pace, Lorenzo, Elphick, Maurice R, Bedse, G, Angelo M. Lavecchia, Gaurav Bedse, GAETANI, SILVANA, VENDEMIALE, GIANLUIGI, LAVECCHIA, ANGELO MICHELE, @CORRESPONDING AUTHOR, Vendemiale, G, CIANCI, SILVIA, Pace Lorenzo, Lorenzo Federico Pace, Adele Romano, Gaetani, S, Tommaso Cassano, BEDSE, GAURAV, Lorenzo, P, Caterina Grillo, Cassano, T, Grillo, C, Laferla, Frank M, ALTIERI, Fabio, Elphick, MR, LaFerla, FM, Maurice R. Elphick, GRILLO, CATERINA, Silvana Gaetani, Frank M. LaFerla, F. m. Laferla, CASSANO, TOMMASO, Lavecchia, AM, Fabio Altieri, Altieri, F, Cianci, S   +39 more
core   +1 more source

Hippocampal atrophy has limited usefulness as a diagnostic biomarker on the early onset Alzheimer's disease patients: A comparison between visual and quantitative assessment

NeuroImage: Clinical, 2019
NIA-AA diagnostic criteria include volumetric or visual rating measures of hippocampal atrophy (HA) as a diagnostic biomarker of Alzheimer's disease (AD).
Neus Falgàs, Raquel Sánchez-Valle, Núria Bargalló, Mircea Balasa, Guadalupe Fernández-Villullas, Beatriz Bosch, Jaume Olives, Adrià Tort-Merino, Anna Antonell, Cristina Muñoz-García, María León, Oriol Grau, Magdalena Castellví, Nina Coll-Padrós, Lorena Rami, Alberto Redolfi, Albert Lladó   +16 more
doaj   +1 more source

Elucidating the role of DEPTOR in Alzheimer's disease [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.The mammalian or mechanistic target of rapamycin (mTOR) is a Ser/Thr protein kinase that, in response to nutrient stimulation, regulates cellular growth, proliferation ...
Karteris, E, Zachariades, E, Rogers-Broadway, K-R, Davies, J, Davies, Julie   +4 more
core   +1 more source

Sex and ethnicity in early‐onset Alzheimer's disease biomarkers and global function

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Early‐onset Alzheimer's disease (EOAD) may have distinct biomarker and clinical features from late‐onset AD (LOAD). EOAD is understudied in ethnically heterogeneous populations. METHODS We studied EOAD (N = 44, age 64.7 ± 5.5, 55% female, 52%
Breton M. Asken, Wei‐En Wang, Franchesca Arias, Shellie‐Anne Levy, Warren W. Barker, Monica Rosselli, Rosie Curiel Cid, Michael Marsiske, Melissa J. Armstrong, David E. Vaillancourt, David A. Loewenstein, Glenn E. Smith, Ranjan Duara   +12 more
doaj   +1 more source

Forecasting the progression of Alzheimer's disease using neural networks and a novel preprocessing algorithm

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction There is a 99.6% failure rate of clinical trials for drugs to treat Alzheimer's disease, likely because Alzheimer's disease (AD) patients cannot be easily identified at early stages. This study investigated machine learning approaches to use
Jack Albright, Alzheimer's Disease Neuroimaging Initiative   +1 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source