Results 21 to 30 of about 154,200 (247)

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

Neurobiology of Disease, 2008
The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou, Jan-Åke Gustafsson, Heikki Tanila, Cecilia Bjorkdahl, Rong Liu, Bengt Winblad, Jin-Jing Pei   +6 more
doaj   +1 more source

Cognitive Decline Detection for Alzheimer’s Disease Patients Through an Activity of Daily Living (ADL)

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022
There are conventional screening instruments for the detection of cognitive impairment, but they have a reduced ecological validity and the information they present could be biased.
G. Palacios-Navarro, J. Buele, S. Gimeno Jarque, A. Bronchal Garcia   +3 more
doaj   +1 more source

Deciphering the factors that influence participation in studies requiring serial lumbar punctures

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Cerebrospinal fluid biomarkers increasingly inform the causes of dementia and may provide objective markers of disease progression. There is a need to decipher participant and procedural factors that promote participation in studies ...
Gregory S. Day, Tracy Rappai, Sushila Sathyan, John C. Morris   +3 more
doaj   +1 more source

The Road to Recovery: A Pilot Study of Driving Behaviors Following Antibody-Mediated Encephalitis

Frontiers in Neurology, 2020
Introduction: Safe driving requires integration of higher-order cognitive and motor functions, which are commonly compromised in patients with antibody-mediated encephalitis (AME) associated with N-methyl-D-aspartate receptors or leucine-rich glioma ...
Gregory S. Day, Gregory S. Day, Ganesh M. Babulal, Ganesh M. Babulal, Ganesh Rajasekar, Sarah Stout, Catherine M. Roe, Catherine M. Roe   +7 more
doaj   +1 more source

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Nature Communications, 2021
Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre ...
Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Serge Gauthier, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, John C. S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group   +20 more
doaj   +1 more source

A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology

Frontiers in Neurology, 2020
Chronic traumatic encephalopathy (CTE) was recently recognized as a new tauopathy in which multifocal perivascular phosphorylated tau aggregates accumulate in neurons, astrocytes, and neurites at the depths of the cortical sulci.
Chunhui Yang, Sukriti Nag, Sukriti Nag, Guoqiang Xing, Neelum T. Aggarwal, Neelum T. Aggarwal, Julie A. Schneider, Julie A. Schneider, Julie A. Schneider   +8 more
doaj   +1 more source

Using the A/T/N Framework to Examine Driving in Preclinical Alzheimer’s Disease

Geriatrics, 2018
The A/T/N classification system is the foundation of the 2018 NIA-AA Research Framework and is intended to guide the Alzheimer disease (AD) research agenda for the next 5–10 years.
Catherine M. Roe, Ganesh M. Babulal, Sarah H. Stout, David B. Carr, Monique M. Williams, Tammie L. S. Benzinger, Anne M. Fagan, David M. Holtzman, Beau M. Ances, John C. Morris   +9 more
doaj   +1 more source

Methyl-CpG Binding Protein 2 in Alzheimer Dementia [PDF]

International Neurourology Journal, 2019
Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp.
Baeksun Kim, Yunjung Choi, Hye-Sun Kim, Heh-In Im   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source