Results 21 to 30 of about 5,368,097 (298)

A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells

Sensors, 2020
Presenilin (PS)/γ-secretase plays a pivotal role in essential cellular events via proteolytic processing of transmembrane proteins that include APP and Notch receptors. However, how PS/γ-secretase activity is spatiotemporally regulated by other molecular
Mei CQ Houser, Steven S Hou, Florian Perrin, Yuliia Turchyna, Brian J Bacskai, Oksana Berezovska, Masato Maesako   +6 more
doaj   +1 more source

Cognitive Decline Detection for Alzheimer’s Disease Patients Through an Activity of Daily Living (ADL)

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022
There are conventional screening instruments for the detection of cognitive impairment, but they have a reduced ecological validity and the information they present could be biased.
G. Palacios-Navarro, J. Buele, S. Gimeno Jarque, A. Bronchal Garcia   +3 more
doaj   +1 more source

Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review [PDF]

Journal of Yeungnam Medical Science, 2022
The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat
Haneol Ko, Sang-Pil Yoon
doaj   +1 more source

Deciphering the factors that influence participation in studies requiring serial lumbar punctures

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Cerebrospinal fluid biomarkers increasingly inform the causes of dementia and may provide objective markers of disease progression. There is a need to decipher participant and procedural factors that promote participation in studies ...
Gregory S. Day, Tracy Rappai, Sushila Sathyan, John C. Morris   +3 more
doaj   +1 more source

The Road to Recovery: A Pilot Study of Driving Behaviors Following Antibody-Mediated Encephalitis

Frontiers in Neurology, 2020
Introduction: Safe driving requires integration of higher-order cognitive and motor functions, which are commonly compromised in patients with antibody-mediated encephalitis (AME) associated with N-methyl-D-aspartate receptors or leucine-rich glioma ...
Gregory S. Day, Gregory S. Day, Ganesh M. Babulal, Ganesh M. Babulal, Ganesh Rajasekar, Sarah Stout, Catherine M. Roe, Catherine M. Roe   +7 more
doaj   +1 more source

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Nature Communications, 2021
Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre ...
Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Serge Gauthier, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, John C. S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group   +20 more
doaj   +1 more source

Using the A/T/N Framework to Examine Driving in Preclinical Alzheimer’s Disease

Geriatrics, 2018
The A/T/N classification system is the foundation of the 2018 NIA-AA Research Framework and is intended to guide the Alzheimer disease (AD) research agenda for the next 5–10 years.
Catherine M. Roe, Ganesh M. Babulal, Sarah H. Stout, David B. Carr, Monique M. Williams, Tammie L. S. Benzinger, Anne M. Fagan, David M. Holtzman, Beau M. Ances, John C. Morris   +9 more
doaj   +1 more source

A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology

Frontiers in Neurology, 2020
Chronic traumatic encephalopathy (CTE) was recently recognized as a new tauopathy in which multifocal perivascular phosphorylated tau aggregates accumulate in neurons, astrocytes, and neurites at the depths of the cortical sulci.
Chunhui Yang, Sukriti Nag, Sukriti Nag, Guoqiang Xing, Neelum T. Aggarwal, Neelum T. Aggarwal, Julie A. Schneider, Julie A. Schneider, Julie A. Schneider   +8 more
doaj   +1 more source

World Alzheimer report 2015: the global impact of dementia [PDF]

, 2015
Today, over 46 million people live with dementia worldwide, more than the population of Spain. This number is estimated to increase to 131.5 million by 2050. Dementia also has a huge economic impact. Today, the total estimated worldwide cost of dementia
Martin Prince
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source