Results 31 to 40 of about 362,575 (339)
Frontiers in Neurology, 2020 Chronic traumatic encephalopathy (CTE) was recently recognized as a new tauopathy in which multifocal perivascular phosphorylated tau aggregates accumulate in neurons, astrocytes, and neurites at the depths of the cortical sulci.
Chunhui Yang +8 more
doaj +1 more source
Methyl-CpG Binding Protein 2 in Alzheimer Dementia [PDF]
International Neurourology Journal, 2019 Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp.
Baeksun Kim +3 more
doaj +1 more source
Preventing the Unnecessary Losses of Alzheimer\u27s Disease [PDF]
, 1998 Educational Objectives 1. To state the importance of early detection and diagnosis of Alzheimer\u27s disease. 2. To describe common concerns of people in the early stages of Alzheimer\u27s disease. 3.
Noyes, Lin E.
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The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. [PDF]
, 2015 Clues to Alzheimer disease (AD) pathogenesis come from a variety of different sources including studies of clinical and neuropathological features, biomarkers, genomics and animal and cellular models. An important role for amyloid precursor protein (APP)
Cheng, Soan +11 more
core +4 more sources
Dissociation of Alzheimer's morphological pathology from cognitive impairment [PDF]
, 2009 We observed the Alzheimer's morphological pathology, amyloid production induces Alzheimer's cognitive impairment, was dissociated from the cognitive impairment.
Nobuyuki Mikoda, Tohru Hasegawa
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Notebook: An Accidental Alzheimer\u27s Awareness Campaign [PDF]
, 2014 My paper examines and critiques the portrayal of Alzheimer¹s disease in the popular film, The Notebook. Based off of a Nicholas Sparks novel, The Notebook uses Alzheimer¹s disease as a vehicle to relay a love story, but in doing so, presents a distorted ...
Waldron, Danielle
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Alzheimer and vascular brain diseases: Focal and diffuse subforms. [PDF]
, 2015 Alois Alzheimer is best known for his description of the pre-senile neurodegenerative disease named after him. However, his previous interest in vascular brain diseases, underlying cognitive and behavioral changes, was very strong. Besides describing the
Engelhardt, Eliasz, Grinberg, Lea T
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