Results 71 to 80 of about 238,162 (269)

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Quick assessment for systematic test statistic inflation/deflation due to null model misspecifications in genome-wide environment interaction studies.

PLoS ONE, 2019
Gene-environment (GxE) interaction is one potential explanation for the missing heritability problem. A popular approach to genome-wide environment interaction studies (GWEIS) is based on regression models involving interactions between genetic variants ...
Masao Ueki, Masahiro Fujii, Gen Tamiya, for Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer’s Disease Metabolomics Consortium   +3 more
doaj   +1 more source

Targeted stabilization of Munc18‐1 function via pharmacological chaperones

EMBO Molecular Medicine, 2020
Heterozygous de novo mutations in the neuronal protein Munc18‐1 cause syndromic neurological symptoms, including severe epilepsy, intellectual disability, developmental delay, ataxia, and tremor.
Debra Abramov, Noah Guy Lewis Guiberson, Andrew Daab, Yoonmi Na, Gregory A Petsko, Manu Sharma, Jacqueline Burré   +6 more
doaj   +1 more source

Additional file 1: of Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimerâ s disease

, 2016
Presents the results of the alternative analysis based on consideration of borderline and positive biomarker values together. (DOCX 27 kb)
Alexopoulos, Panagiotis, Werle, Lukas, Roesler, Jennifer, Thierjung, Nathalie, Gleixner, Lena, Yakushev, Igor, Laskaris, Nikolaos, Wagenpfeil, Stefan, Gourzis, Philippos, Kurz, Alexander, Perneczky, Robert   +10 more
openaire   +1 more source

Additional file 1: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S1. Effects of the treatment with an anti-TNFSF10 monoclonal antibody on the expression of GITR and FoxP3, as well as the anti-inflammatory protein IL-10 in the hippocampus of 3xTg-AD mice. Representative immunofluorescence images of hippocampi for GITR and FoxP3 expression and co-localization from the same animal groups as above (merge column ...
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Additional file 4: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S4. Co-localization of GITR and Foxp3 in the human AD brain. Immunofluorescence in representative samples for both molecules was detected in immune cells in the hippocampus of AD patients, whereas it was practically absent in the brain of healthy individuals (merge column; DAPIâ =â nuclear staining).
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Additional file 7: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S7. Negative controls for Fig. 8, panel b (phosphorylated Tau protein expression). Negative controls are reported in all panels marked with acronyms of secondary antibodies labeled with, Alexa Fluor 488. (PDF 491 kb)
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source