Results 91 to 100 of about 647,233 (310)

Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease

open access: yesTranslational Neurodegeneration, 2021
Background Neuropsychiatric symptoms (NPS) are increasingly recognized as early non-cognitive manifestations in the Alzheimer’s disease (AD) continuum.
Kok Pin Ng   +12 more
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer   +3 more
wiley   +1 more source

Additional file 1: of Attitudes toward clinical trials across the Alzheimerâ s disease spectrum

open access: yes, 2017
Appendix. (DOC 59 kb)
NuĂąo, Michelle   +6 more
openaire   +1 more source

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt   +8 more
wiley   +1 more source

Variation in TMEM106B in chronic traumatic encephalopathy

open access: yesActa Neuropathologica Communications, 2018
The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative disease, and ...
Jonathan D. Cherry   +26 more
doaj   +1 more source

On bloodvessel branching analysis for the detection of Alzheimer's disease

open access: yes, 2014
Alzheimer’s Disease (AD) is increasingly prevalent in modern society and methods for its diagnosis are only just starting to emerge. Given images of brain tissue, we show how Alzheimer’s disease can be detected from the branching structures of blood ...
Carare, Roxana O.   +2 more
core  

Effect of ApoE E4 Variant on Progression from Mild Cognitive Impairment to Alzheimer’s Disease [PDF]

open access: yes, 2016
Alzheimer’s disease is a very prevalent and fatal disorder in older adults, and Mild Cognitive Impairment is often seen as a precursor to Alzheimer’s disease.
Taylor, Brad P
core   +1 more source

End-of-life care and dementia [PDF]

open access: yes, 2006
In the UK, research continues to confirm that people with certain chronic illnesses, such as chronic lung disease and cardiac failure, represent the ‘disadvantaged dying’ compared to those with terminal cancer.
Ballard, Clive   +5 more
core   +1 more source

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