Results 91 to 100 of about 5,180,843 (313)

Diet moderates the effect of resting state functional connectivity on cognitive function

Scientific Reports, 2022
Past research suggests modifiable lifestyle factors impact structural and functional measures of brain health, as well as cognitive performance, but no study to date has tested the effect of diet on resting state functional connectivity (rsFC), and its ...
Alexandra M. Gaynor, Eleanna Varangis, Suhang Song, Yunglin Gazes, Diala Noofoory, Reshma S. Babukutty, Christian Habeck, Yaakov Stern, Yian Gu   +8 more
doaj   +1 more source

MOESM1 of Histone post-translational modifications in frontal cortex from human donors with Alzheimerâ s disease

, 2015
Additional file 1: Table S1. Donor information.
Anderson, Kyle, Turko, Illarion
openaire   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Clinicial and cost-effectiveness of donepezil, rivastigmine and galantamine for Alzheimer's disease: a rapid and systematic review [PDF]

, 2001
Background Alzheimer’s disease is the most common cause of dementia and is characterised by an insidious onset and slow deterioration. The estimated prevalence of Alzheimer’s disease for a standard health authority (500,000 people) is about 3330. Current
A. Clegg, N. Waugh, S. De Broe, Gerard, K., Bryant, J., K. Gerard, Clegg, A. J., McIntyre, Linda, L. McIntyre, Bryant, Jackie, Gerard, Karen, Waugh, Norman, McIntyre, L., Nicholson, T., T. Nicholson, De Broe, S., Clegg, A., Waugh, N., J. Bryant   +18 more
core   +1 more source

Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis

, 2021
Accumulating evidence has suggested a shared pathophysiology between Alzheimer’s disease (AD) and cardiovascular disease (CVD). Based on genome-wide transcriptomes, specifically those of blood samples, we identify the shared disease-related signatures ...
the Alzheimer’s Disease Neuroimaging Initiative, Hyunju Lee, Taesic Lee, the Alzheimer’s Disease Neuroimaging Initiative the Alzheimer’s Disease Neuroimaging Initiative   +3 more
core   +1 more source

Pathogenic PS1 phosphorylation at Ser367

eLife, 2017
The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ...
Masato Maesako, Jana Horlacher, Katarzyna M Zoltowska, Ksenia V Kastanenka, Eleanna Kara, Sarah Svirsky, Laura J Keller, Xuejing Li, Bradley T Hyman, Brian J Bacskai, Oksana Berezovska   +10 more
doaj   +1 more source

The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults

Alzheimer’s Research & Therapy, 2023
Background Insulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer’s clinical syndrome in epidemiologic studies but have not been associated with tau tangles in neuropathological research and have been ...
Gilda E. Ennis, Tobey J. Betthauser, Rebecca Langhough Koscik, Nathaniel A. Chin, Bradley T. Christian, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin   +7 more
doaj   +1 more source

Additional file 4: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S4. Co-localization of GITR and Foxp3 in the human AD brain. Immunofluorescence in representative samples for both molecules was detected in immune cells in the hippocampus of AD patients, whereas it was practically absent in the brain of healthy individuals (merge column; DAPIâ =â nuclear staining).
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults

Communications Biology
Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected.
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett   +10 more
doaj   +1 more source