Results 111 to 120 of about 400,612 (318)

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Social capabilities in Alzheimer’s patients [PDF]

Patients with stage-I (very mild and mild) Alzheimer’s disease were asked to participate in a Dictator Game, a type of game in which a subject has to decide how to allocate a certain amount of money between himself and another person.
Rosemarie Nagel, Juan Vicente Sánchez-Andrés, Antoni Bosch-Domènech   +2 more
core  

Genetic Linkage Studies in Late-Onset Alzheimer’s Disease Families

, 1988
Alzheimer’s disease (AD) is a devastating neurological disorder and the leading cause of dementia among the elderly. Recent studies have localized the gene for familial AD to chromosome 21 in a series of early-onset AD families (EOAD; mean age-of-onset,
Hung, W.-Y, J. P. Eisenmenger, P. C. Gaskell, Heyman, A. L, Pericak-Vance, M. A, J. E. Lee, M. J. Alberts, Haynes, C. S, Eisenmenger, J. P, J. A. Trofatter, C. S. Haynes, Gilbert, J. R, Clark, C. M, Roses, A. D, Yamaoka, L. H, R. J. Bartlett, Trofatter, J. A, M. A. Pericak-Vance, A. L. Heyman, W.-Y. Hung, Haines, J. L, Earl, N. L, Dawson, D. V, D. V. Dawson, Bartlett, R. J, T. Siddique, Siddique, T, J. R. Gilbert, Speer, M. C, M. C. Speer, Lee, J. E, Alberts, M. J, L. H. Yamaoka, A. D. Roses, Gaskell, P. C, C. M. Clark, N. L. Earl, J. L. Haines   +37 more
core   +1 more source

How does a woman with Alzheimer’s disease make sense of becoming cared for? [PDF]

, 2016
This case study explores the meaning one woman with Alzheimer’s disease gives to receiving assistance with instrumental activities of daily living (IADL) from her spouse.
Gayle Borley, Sarah Church, Borley, Gayle, Judith Sixsmith, Sixsmith, Judith, Sixsmith, Judith; id_orcid, Church, Sarah   +6 more
core   +1 more source

Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias

Acta Neuropathologica Communications
Pick’s disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterized by intraneuronal 3R-tau inclusions.
Allegra Kawles, Rachel Keszycki, Grace Minogue, Antonia Zouridakis, Ivan Ayala, Nathan Gill, Alyssa Macomber, Vivienne Lubbat, Christina Coventry, Emily Rogalski, Sandra Weintraub, Qinwen Mao, Margaret E. Flanagan, Hui Zhang, Rudolph Castellani, Eileen H. Bigio, M.-Marsel Mesulam, Changiz Geula, Tamar Gefen   +18 more
doaj   +1 more source

Additional file 7: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S7. Negative controls for Fig. 8, panel b (phosphorylated Tau protein expression). Negative controls are reported in all panels marked with acronyms of secondary antibodies labeled with, Alexa Fluor 488. (PDF 491 kb)
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Biomolecular studies in Alzheimer’s Disease models: investigations in vitro and in vivo

, 2013
The Alzheimer’s disease (AD), the most prevalent form of age-related dementia, is a multifactorial and heterogeneous neurodegenerative disease. The molecular mechanisms underlying the pathogenesis of AD are yet largely unknown.
Lattanzio, Francesca <1982>
core   +1 more source

Additional file 4: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Figure S4. Co-localization of GITR and Foxp3 in the human AD brain. Immunofluorescence in representative samples for both molecules was detected in immune cells in the hippocampus of AD patients, whereas it was practically absent in the brain of healthy individuals (merge column; DAPIâ =â nuclear staining).
Di Benedetto, Giulia, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source