Results 131 to 140 of about 400,612 (318)

Proteomic analysis of inflammatory protein expression patterns in cell culture and transgenic animal models for Alzheimer's disease [PDF]

, 2004
Dementia is a syndrome characterized by failure of recent memory and other cognitive functions that is usually insidious in onset but steadily progresses with age. Alzheimer’s disease (AD) is the most common form of senile dementia.
Augé, Christelle
core   +1 more source

Proteomic analysis in Alzheimer’s disease and other dementias: a focus on sex-specific differences

Alzheimer’s Research & Therapy
Background Fluid protein studies in cerebrospinal fluid (CSF) and plasma have provided important insights into neurodegenerative dementias; however, there is a limited investigation of sex-related differences and cross-biofluid relationships.
Aina Comas-Albertí, Albert Lladó, Diana Esteller-Gauxax, Sergi Borrego-Écija, Neus Falgàs, Farida Dakterzada, Agnès Pérez-Millan, Roger Puey, Tània Collet-Romà, Núria Guillén, Miquel Massons, Adrià Tort-Merino, Josep Maria Augé, Guadalupe Fernandez-Villullas, Bea Bosch, Raquel Ruiz-García, Laura Naranjo, Mircea Balasa, Gerard Piñol-Ripoll, Anna Antonell, Raquel Sánchez-Valle   +20 more
doaj   +1 more source

Degenerate codon mixing for PCR-based manipulation of highly repetitive sequences

BMC Research Notes, 2018
Objective Repeat expansion of polyglutamine tracks leads to a group of inherited human neurodegenerative disorders. Studying such repetitive sequences is required to gain insight into the pathophysiology of these diseases.
Dhanushika Ratnayake, Morgan Newman, Michael Lardelli   +2 more
doaj   +1 more source

Additional file 1: Table S1. of Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimerâ s disease

, 2016
Details of patients with other neurodegenerative diseases. (DOCX 13 kb)
Heslegrave, Amanda, Heywood, Wendy, Paterson, Ross, Magdalinou, Nadia, Svensson, Johan, Johansson, Per, ÖHrfelt, Annika, Blennow, Kaj, Hardy, John, Schott, Jonathan, Mills, Kevin, Zetterberg, Henrik   +11 more
openaire   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

The Assessment of Behavioural Decline in Adults with Down's Syndrome

, 2002
The present study examines two methods of using the Vineland Adaptive Behaviour Scales as a measure of behavioural change in people with Down syndrome who are at risk of developing Alzheimer’s disease.
Harte, Cyan, Matheson, Edith, Patrick, Shona, McKenzie, Karen, Murray, George   +4 more
core   +1 more source

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

Nature Communications
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao, Julita Chlebowicz, Karlton Gaskin, Juan A. Briano, Lauren E. Komer, André Pineda, Shrey Jhalani, Saad Ahmad, Eseosa Uwaifo, Luca S. Black, Jillian E. Haller, Serge Przedborski, Diane A. Lane, Sheng Zhang, Manu Sharma, Jacqueline Burré   +15 more
doaj   +1 more source

Additional file 1: of Rubidium and potassium levels are altered in Alzheimerâ s disease brain and blood but not in cerebrospinal fluid

, 2016
ROC analysis of Rb & K levels in plasma (Figure S1) and platelets (Figure S2). (DOCX 1297 kb)
Roberts, Blaine, Doecke, James, Rembach, Alan, L. YĂŠvenes, Fowler, Christopher, McLean, Catriona, Lind, Monica, Volitakis, Irene, Masters, Colin, Bush, Ashley, Hare, Dominic   +10 more
openaire   +1 more source

Problematic Internet Use in Frontotemporal Dementia: A Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The present study investigated problematic internet use (PIU) among 61 patients with frontotemporal dementia (FTD) compared to a cohort of 354 patients with mild cognitive impairment (MCI) and Alzheimer's dementia. PIU was identified in 22.9% of FTD patients compared to only 0.8% of AD patients (p < 0.001). Behaviors included compulsive social
Daniele Urso, Giuseppe Volpe, Agnese Valguarnera, Davide Vilella, Alessandra Vitulli, Valentina Gnoni, Alessia Giugno, Eleonora Rollo, Mark D. Griffiths, Giancarlo Logroscino   +9 more
wiley   +1 more source

Additional file 1: Table S1. of Disease-related determinants are associated with mortality in dementia due to Alzheimerâ s disease

, 2018
Cox proportional hazard models using nonimputed data; influence of baseline characteristics and medical history on survival status. Table S2. Cox proportional hazard models based on nonimputed data; influence of CSF and MRI on survival status. (DOCX 26 kb)
Rhodius-Meester, Hanneke, Liedes, Hilkka, Koene, Ted, Lemstra, Afina, Teunissen, Charlotte, Barkhof, Frederik, Scheltens, Philip, van Gils, Mark, LĂśtjĂśnen, Jyrki, van der Flier, Wiesje   +9 more
openaire   +1 more source