Results 151 to 160 of about 5,180,843 (313)

Additional file 5: of Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimerâ s disease

, 2019
Figure S1. Quantitative abundances of the proteins involved in mitochondrial fusion and fission and mitoribosomes in brain proteomes of early onset AD (log2 (115/114)), late onset AD (log2 (117/116)) and healthy aging subjects (log2 (116/114)). A) iTRAQ quantitative ratios of proteins involved in mitochondrial fusion and fission, B) and C) iTRAQ ...
Adav, Sunil, Park, Jung, Sze, Siu
openaire   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Alzheimer and the Mediterranean report 2016 : overview – challenges – perspectives

, 2016
This report is the first paper to discuss the issues concerning Alzheimer’s disease and related disorders in the Mediterranean region. It aims to assess needs related to the illness and to analyse the emerging medical and social challenges in the region.
Guetin, Stephane, Georges, Jean, Ceccaldi, Mathieu, Lefeuvre, Karine, Naja, Nabil, Kocaman, Fusun, Scerri, Charles, Zlobec, Stefania, Alouane, Leila, Desana, Marie-Odile, Gzil, Fabrice, Kusan Jukic, Marija, Louchart de la Chapelle, Sandrine, Palermiti, Federico, Castel Tallet, Marie Antoinette, Vellas, Bruno, Tsolaki, Magda, Ankri, Joel, Nicaise, Salome, Kissani, Najib, Bartorelli, Luisa, Gelonch, Antoni, Ngatcha-Ribert, Laetitia, Mneimneh, Mira, Do Rosario Zincke, Maria, Monegasque Association for Research on Alzheimer’s disease (AMPA), Wortmann, Marc, Touchan, Jacques, Seleari, Maria, Hirsch, Emmanuel, Mimica, Ninoslav, Abdul-Rahman, Miriam, Alouane, Sandrine, Pesce, Alain   +33 more
core  

Metabolite profiling of Alzheimer's disease cerebrospinal fluid [PDF]

, 2012
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive functions. Today the diagnosis of AD relies on clinical evaluations and is only late in the disease.
Schmitz, Oliver, Czech, Christian, Senn Hans, Hampel Harald, Kristina Busch, Oliver Schmitz, Veronique Most (183225), Wiemer Jan, Wiemer, Jan, Jan Wiemer, Hans Senn, Jürgen Kastler, Peter Berndt, Harald Hampel, Schmitz Oliver, Jürgen Kastler (183232), Kastler, Jürgen, Christian Czech, Peter Berndt (183205), Busch, Kristina, Kristina Busch (183211), Jan Wiemer (183220), Veronique Most, Hans Senn (183234), Hampel, Harald, Oliver Schmitz (183214), Berndt, Peter, Berndt Peter, Most, Veronique, Harald Hampel (183230), Czech Christian, Most Veronique, Christian Czech (183197), Senn, Hans, Busch Kristina, Kastler Jürgen   +35 more
core   +2 more sources

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

Nature Communications
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao, Julita Chlebowicz, Karlton Gaskin, Juan A. Briano, Lauren E. Komer, André Pineda, Shrey Jhalani, Saad Ahmad, Eseosa Uwaifo, Luca S. Black, Jillian E. Haller, Serge Przedborski, Diane A. Lane, Sheng Zhang, Manu Sharma, Jacqueline Burré   +15 more
doaj   +1 more source

Additional file 12: Table S3. of Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimerâ s disease model

, 2017
List of the C3 cytokine array data. (PDF 24088 kb)
Liu, Yi-Ling, Chen, Wei-Ting, Yu-Yi Lin, Po-Hung Lu, Shie-Liang Hsieh, Cheng, Irene   +5 more
openaire   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Additional file 1: of Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimerâ s disease

, 2019
Table S1. Proteins related to neuronally derived EVs of Alzheimerâ s disease patients (DOCX 95 kb)
Watson, Luke, Hamlett, Eric, Stone, Tyler, Sims-Robinson, Catrina   +3 more
openaire   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Alzheimer’s Disease: Theories of Causation

Alzheimer’s disease will be the epidemic of the twenty-first century (1,2). The generally accepted figures are that 5% of individuals of the age of 65 have severe dementia, and another 10% have moderate dementia, with 30% having developed dementia if ...
Bradley, Walter G
core   +1 more source