Results 151 to 160 of about 400,612 (318)

Additional file 1: of Identification of exon skipping events associated with Alzheimerâ s disease in the human hippocampus

, 2019
Figure S1. Functional impact of the AD-associated exon skipping event (exon 37) in RELN. (A) Schema of the potential functional implication of exon skipping and splicing-associated SNP. (B) Normalized expression levels for exon 37 between AD and CN participants.
Han, Seonggyun, Miller, Jason, Byun, Seyoun, Kim, Dokyoon, Risacher, Shannon, Saykin, Andrew, Lee, Younghee, Nho, Kwangsik   +7 more
openaire   +1 more source

Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified STAM3mP Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM3P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the ...
R. W. van Steenhoven, N. Satyadev, A. E. M. Bastiaansen, Y. D. Piura, J. Kerstens, Y. S. Crijnen, J. Brenner, T. Brand, T. M. Bienfait, S. Veenbergen, J. M. de Vries, F. J. de Jong, E. G. P. Dopper, P. A. E. Sillevis Smitt, H. Seelaar, G. S. Day, M. J. Titulaer   +16 more
wiley   +1 more source

Metal Ions in Alzheimer’s disease brain [PDF]

, 2015
There is substantial evidence supporting a critical role for metal ions in the pathogenesis of Alzheimer’s disease (AD). This originated with the observation that certain metal ions (principally copper, iron and zinc) are enriched in the neuritic plaques
Sastre, M, Hajji, N, Ritchie, CW
core  

Additional file 1: of Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimerâ s disease

, 2019
Table S1. Participantsâ family mutations. (DOCX 17 kb)
Weston, Philip, Poole, Teresa, O’Connor, Antoinette, Heslegrave, Amanda, Ryan, Natalie, Liang, Yuying, Druyeh, Ronald, Mead, Simon, Blennow, Kaj, Schott, Jonathan, Frost, Chris, Zetterberg, Henrik, Fox, Nick   +12 more
openaire   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Additional file 1: of Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimerâ s disease

, 2019
Table S1. Proteins related to neuronally derived EVs of Alzheimerâ s disease patients (DOCX 95 kb)
Watson, Luke, Hamlett, Eric, Stone, Tyler, Sims-Robinson, Catrina   +3 more
openaire   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Structural imaging biomarkers of Alzheimer’s disease: predicting disease progression

, 2015
Optimized magnetic resonance imaging (MRI)–based biomarkers of Alzheimer's disease (AD) may allow earlier detection and refined prediction of the disease.
Collins, Louis, Eskildsen, Simon F., Collins, D. Louis, Pruessner, Jens C., Fonov, Vladimir, Eskildse, Simon F., Fonov, Vladimir S., Coupé, Pierrick   +7 more
core   +1 more source

Additional file 2: of Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimerâ s disease

, 2016
BEATADStatisticalPlanFinal_1 3_20141209. (DOC 467 kb)
Cummings, Jeffrey, Zhong, Kate, Kinney, Jefferson, Heaney, Chelcie, Moll-Tudla, Joanne, Joshi, Abhinay, Pontecorvo, Michael, Devous, Michael, Tang, Anne, Bena, James   +9 more
openaire   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source