Results 171 to 180 of about 400,612 (318)

Additional file 2: Table S2. of Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimerâ s disease model

, 2017
Statement on sample size and statistical measures. (PDF 1351 kb)
Liu, Yi-Ling, Chen, Wei-Ting, Lin, Yu-Yi, Lu, Po-Hung, Hsieh, Shie-Liang, Cheng, Irene   +5 more
openaire   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source

Metabolite profiling of Alzheimer's disease cerebrospinal fluid

, 2012
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive functions. Today the diagnosis of AD relies on clinical evaluations and is only late in the disease.
Schmitz, Oliver, Czech, Christian, Senn Hans, Hampel Harald, Kristina Busch, Oliver Schmitz, Veronique Most (183225), Wiemer Jan, Wiemer, Jan, Jan Wiemer, Hans Senn, Jürgen Kastler, Peter Berndt, Harald Hampel, Schmitz Oliver, Jürgen Kastler (183232), Kastler, Jürgen, Christian Czech, Peter Berndt (183205), Busch, Kristina, Kristina Busch (183211), Jan Wiemer (183220), Veronique Most, Hans Senn (183234), Hampel, Harald, Oliver Schmitz (183214), Berndt, Peter, Berndt Peter, Most, Veronique, Harald Hampel (183230), Czech Christian, Most Veronique, Christian Czech (183197), Senn, Hans, Busch Kristina, Kastler Jürgen   +35 more
core   +1 more source

Additional file 1: Table S1. of Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimerâ s disease with cerebrovascular disease

, 2017
Detail of the human postmortem brain tissues analyzed. (DOC 34Â kb)
Gallart-Palau, Xavier, Serra, Aida, Lee, Benjamin, Guo, Xue, Siu Sze   +4 more
openaire   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Additional file 1: Figure S1. of Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimerâ s disease

, 2016
A representative image of methylene blue staining showing the equal spotting of DNA in the membrane. Figure S2 5hmC chromosome-wide densities showing the distribution profiling on chromosomes. A depletion is observed on chr-X relative to autosomes. Figure S3 Representative IGV images show the decrease of 5hmC in some genomic regions of genes identified
Shu, Liqi, Sun, Wenjia, Li, Liping, Xu, Zihui, Lin, Li, Xie, Pei, Shen, Hui, Huang, Luoxiu, Xu, Qi, Jin, Peng, Li, Xuekun   +10 more
openaire   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Additional file 2: of PU.1 regulates Alzheimerâ s disease-associated genes in primary human microglia

, 2018
Table S2. List of antibodies and reagents for ICC and IHC (DOCX 17 kb)
Rustenhoven, Justin, Smith, Amy, Smyth, Leon, Jansson, Deidre, Scotter, Emma, Swanson, Molly, Aalderink, Miranda, Coppieters, Natacha, Narayan, Pritika, Handley, Renee, Overall, Chris, Park, Thomas, Schweder, Patrick, Heppner, Peter, Curtis, Maurice, Faull, Richard, Dragunow, Mike   +16 more
openaire   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Additional file 3: of PU.1 regulates Alzheimerâ s disease-associated genes in primary human microglia

, 2018
Table S3. List of primers used for qRT-PCR (DOCX 18 kb)
Rustenhoven, Justin, Smith, Amy, Smyth, Leon, Jansson, Deidre, Scotter, Emma, Swanson, Molly, Aalderink, Miranda, Coppieters, Natacha, Narayan, Pritika, Handley, Renee, Overall, Chris, Park, Thomas, Schweder, Patrick, Heppner, Peter, Curtis, Maurice, Faull, Richard, Dragunow, Mike   +16 more
openaire   +1 more source