Results 171 to 180 of about 5,180,843 (313)

Structural imaging biomarkers of Alzheimer’s disease: predicting disease progression

, 2015
Optimized magnetic resonance imaging (MRI)–based biomarkers of Alzheimer's disease (AD) may allow earlier detection and refined prediction of the disease.
Collins, Louis, Eskildsen, Simon F., Collins, D. Louis, Pruessner, Jens C., Fonov, Vladimir, Eskildse, Simon F., Fonov, Vladimir S., Coupé, Pierrick   +7 more
core   +1 more source

Additional file 2: of PU.1 regulates Alzheimerâ s disease-associated genes in primary human microglia

, 2018
Table S2. List of antibodies and reagents for ICC and IHC (DOCX 17 kb)
Rustenhoven, Justin, Smith, Amy, Smyth, Leon, Jansson, Deidre, Scotter, Emma, Swanson, Molly, Aalderink, Miranda, Coppieters, Natacha, Narayan, Pritika, Handley, Renee, Overall, Chris, Park, Thomas, Schweder, Patrick, Heppner, Peter, Curtis, Maurice, Faull, Richard, Dragunow, Mike   +16 more
openaire   +1 more source

Modeling stimulus-induced stress responses in microglia-like cells using a commercial iPSC-dCas9-KRAB line

Stem Cell Research
Commercially available human iPSC lines with inducible CRISPR interference (CRISPRi) systems offer scalable platforms for gene function studies. One widely available line, the AICS-0090 dCas9-KRAB iPSC line developed by the Allen Institute, has been ...
Devin M. Saunders, Nicola A. Kearns, Bernard Ng, Faraz Sultan, Himanshu Vyas, Ricardo A. Vialle, Eric M. Clark, Sashini De Tissera, Jishu Xu, David A. Bennett, Yanling Wang   +10 more
doaj   +1 more source

Additional file 1: Figure S1. of Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimerâ s disease

, 2016
A representative image of methylene blue staining showing the equal spotting of DNA in the membrane. Figure S2 5hmC chromosome-wide densities showing the distribution profiling on chromosomes. A depletion is observed on chr-X relative to autosomes. Figure S3 Representative IGV images show the decrease of 5hmC in some genomic regions of genes identified
Shu, Liqi, Sun, Wenjia, Li, Liping, Xu, Zihui, Lin, Li, Xie, Pei, Shen, Hui, Huang, Luoxiu, Xu, Qi, Jin, Peng, Li, Xuekun   +10 more
openaire   +1 more source

Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to test the hypothesis that multijoint osteoarthritis would modify the relation between time and frailty progression, in which more affected joints would lead to larger declines over six years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.
Carson Halliwell, Rebecca Moyer, Myles W. O'Brien   +2 more
wiley   +1 more source

Metal Ions in Alzheimer’s disease brain [PDF]

, 2015
There is substantial evidence supporting a critical role for metal ions in the pathogenesis of Alzheimer’s disease (AD). This originated with the observation that certain metal ions (principally copper, iron and zinc) are enriched in the neuritic plaques
Sastre, M, Hajji, N, Ritchie, CW
core  

Additional file 1: of Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimerâ s disease

, 2016
BexProtocol-Ver#2-8-1-12. (DOC 299 kb)
Cummings, Jeffrey, Zhong, Kate, Kinney, Jefferson, Chelcie Heaney, Moll-Tudla, Joanne, Abhinay Joshi, Pontecorvo, Michael, Devous, Michael, Tang, Anne, Bena, James   +9 more
openaire   +1 more source

A Scoping Review and Meta‐Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease

Arthritis Care &Research, Accepted Article.
Objective The objective of this scoping review was to synthesize evidence on the proportion of individuals living with Sjögren's disease who experience central nervous system (CNS) manifestations. Methods We searched MEDLINE (via PubMed) and Embase from 1980 through January 29, 2026, and the ECRI Guidelines Trust from 2020 through January 29, 2026 ...
Arun Varadhachary, Ghaith Noaiseh, Julie Frantsve‐Hawley, Frederick B. Vivino, Jennifer A. McCombe, Shamik Bhattacharyya, E. Sherwood Brown, Andrew R. Carey, Robert Fox, Thomas Grader‐Beck, Janet E. Lewis, Stephen Maitz, Steven Mandel, Astrid Rasmussen, George Sarka, R. Hal Scofield, Daniel J. Wallace, Rochelle Zak, Kristie Cox, Katherine M. Hammitt, Steven Carsons, Nancy Carteron   +21 more
wiley   +1 more source

Additional file 2: of Psychosocial interventions for Alzheimerâ s disease cognitive symptoms: a Bayesian network meta-analysis

, 2018
Risk of Bias Graph. (DOCX 31 kb)
Duan, Yuting, Lu, Liming, Chen, Juexuan, Wu, Chunxiao, Liang, Jielin, Zheng, Yan, Wu, Jinjian, Rong, Peijing, Tang, Chunzhi   +8 more
openaire   +1 more source

Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks

Advanced Functional Materials, EarlyView.
This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran, Kalyan Shobhana, Zlatan Trifunovic, Dan Smith, Michael Stuiber, Chennupati Jagadish, Mirella Dottori, Andrea J. O'Connor, Vini Gautam   +8 more
wiley   +1 more source