Results 161 to 170 of about 400,612 (318)

Modeling stimulus-induced stress responses in microglia-like cells using a commercial iPSC-dCas9-KRAB line

Stem Cell Research
Commercially available human iPSC lines with inducible CRISPR interference (CRISPRi) systems offer scalable platforms for gene function studies. One widely available line, the AICS-0090 dCas9-KRAB iPSC line developed by the Allen Institute, has been ...
Devin M. Saunders, Nicola A. Kearns, Bernard Ng, Faraz Sultan, Himanshu Vyas, Ricardo A. Vialle, Eric M. Clark, Sashini De Tissera, Jishu Xu, David A. Bennett, Yanling Wang   +10 more
doaj   +1 more source

Additional file 12: Table S3. of Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimerâ s disease model

, 2017
List of the C3 cytokine array data. (PDF 24088 kb)
Liu, Yi-Ling, Chen, Wei-Ting, Yu-Yi Lin, Po-Hung Lu, Shie-Liang Hsieh, Cheng, Irene   +5 more
openaire   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Additional file 1: of Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimerâ s disease

, 2017
Supplementary Experimental Procedures. Figure S1. The topological overlap matrix plot of the protein co-expression network constructed from the proteomics data from the autopsied brains in the MSBB cohort, along with the dendrogram showing the tree cutting process used to define modules (above). Figure S2.
McKenzie, Andrew, Moyon, Sarah, Wang, Minghui, Katsyv, Igor, Song, Won-Min, Zhou, Xianxiao, Dammer, Eric, Duong, Duc, Aaker, Joshua, Zhao, Yongzhong, Beckmann, Noam, Wang, Pei, Zhu, Jun, Lah, James, Seyfried, Nicholas, Levey, Allan, Katsel, Pavel, Haroutunian, Vahram, Schadt, Eric, Popko, Brian, Casaccia, Patrizia, Zhang, Bin   +21 more
openaire   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Pharmacotherapy for Alzheimer’s disease

The introduction outlines the biochemical foundations of Alzheimer’s disease (AD). The following chapter provides a general overview of dementia as a collective term, followed by a detailed discussion of the symptoms, diagnostic criteria, and stages of ...
Losin, Stanislav
core  

Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimer's Disease

Acta Neuropathologica Communications
Alzheimer’s Disease (AD) is marked by the accumulation of pathology, neuronal loss, and gliosis and frequently accompanied by decline in cognition.
Katia de Paiva Lopes, Ricardo A. Vialle, Gilad Green, Masashi Fujita, Chris Gaiteri, Vilas Menon, Julie A. Schneider, Yanling Wang, Philip L. De Jager, Naomi Habib, Shinya Tasaki, David A. Bennett   +11 more
doaj   +1 more source

Additional file 1: of Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimerâ s disease

, 2016
BexProtocol-Ver#2-8-1-12. (DOC 299 kb)
Cummings, Jeffrey, Zhong, Kate, Kinney, Jefferson, Chelcie Heaney, Moll-Tudla, Joanne, Abhinay Joshi, Pontecorvo, Michael, Devous, Michael, Tang, Anne, Bena, James   +9 more
openaire   +1 more source

Enhanced Strength and Corrosion Resistance of Ti‐13Nb‐12Ta‐10Zr‐4Sn Alloy by Aging Treatment

Advanced Engineering Materials, EarlyView.
This work systematically investigates the effect of aging treatment on mechanical properties and corrosion behavior of vacuum arc‐melted Ti‐13Nb‐12Ta‐10Zr‐4Sn alloy. Owing to the increased α″ martensite, strength and corrosion resistance were significantly enhanced by aging treatment.
Yuhua Li, Rong Zhao, Qian Zhang, Haojie Wang, Yujing Liu, Lai‐Chang Zhang   +5 more
wiley   +1 more source

World Alzheimer report 2015: the global impact of dementia [PDF]

, 2015
Today, over 46 million people live with dementia worldwide, more than the population of Spain. This number is estimated to increase to 131.5 million by 2050. Dementia also has a huge economic impact. Today, the total estimated worldwide cost of dementia
Martin Prince
core