Results 141 to 150 of about 400,612 (318)

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Alzheimer and the Mediterranean report 2016 : overview – challenges – perspectives

, 2016
This report is the first paper to discuss the issues concerning Alzheimer’s disease and related disorders in the Mediterranean region. It aims to assess needs related to the illness and to analyse the emerging medical and social challenges in the region.
Guetin, Stephane, Georges, Jean, Ceccaldi, Mathieu, Lefeuvre, Karine, Naja, Nabil, Kocaman, Fusun, Scerri, Charles, Zlobec, Stefania, Alouane, Leila, Desana, Marie-Odile, Gzil, Fabrice, Kusan Jukic, Marija, Louchart de la Chapelle, Sandrine, Palermiti, Federico, Castel Tallet, Marie Antoinette, Vellas, Bruno, Tsolaki, Magda, Ankri, Joel, Nicaise, Salome, Kissani, Najib, Bartorelli, Luisa, Gelonch, Antoni, Ngatcha-Ribert, Laetitia, Mneimneh, Mira, Do Rosario Zincke, Maria, Monegasque Association for Research on Alzheimer’s disease (AMPA), Wortmann, Marc, Touchan, Jacques, Seleari, Maria, Hirsch, Emmanuel, Mimica, Ninoslav, Abdul-Rahman, Miriam, Alouane, Sandrine, Pesce, Alain   +33 more
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Additional file 1: of Bapineuzumab for mild to moderate Alzheimerâ s disease: a meta-analysis of randomized controlled trials

, 2017
Shows the reasons for exclusion of retrieved articles during full text screening. (DOCX 31 kb)
Abdelrahman Abushouk, Elmaraezy, Ahmed, Aglan, Amro, Reham Salama, Fouda, Samar, Fouda, Rana, AlSafadi, Ammar   +6 more
openaire   +1 more source

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

Final Report: 2007 Alzheimer's Disease Task Force, January 2008

, 2008
Following an overview of the history of the task force and background information on Alzheimer’s disease, the report is divided into four sections. These sections correspond to the delineation of four subcommittees into which task force members were ...

core  

Additional file 7: Figure S2. of Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimerâ s disease with cerebrovascular disease

, 2016
Structural alignment of human and bovine MBP sequences. EMBOSS_001 corresponds to human MBP and MBP_Bovine corresponds to bovine MBP. (PDF 231Â kb)
Gallart-Palau, Xavier, Lee, Benjamin, Adav, Sunil, Jingru Qian, Serra, Aida, Park, Jung, Lai, Mitchell, Chen, Christopher, Kalaria, Raj, Siu Sze   +9 more
openaire   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Additional file 5: of Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimerâ s disease

, 2019
Figure S1. Quantitative abundances of the proteins involved in mitochondrial fusion and fission and mitoribosomes in brain proteomes of early onset AD (log2 (115/114)), late onset AD (log2 (117/116)) and healthy aging subjects (log2 (116/114)). A) iTRAQ quantitative ratios of proteins involved in mitochondrial fusion and fission, B) and C) iTRAQ ...
Adav, Sunil, Park, Jung, Sze, Siu
openaire   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Investigating Therapeutic Strategies in a Preclinical Model for Alzheimer’s Disease

, 2017
Alzheimer’s disease (AD) is a worldwide, incurable disease, and the most common form of dementia. Numbers of cases are rising, and since its discovery the only approved medications have treated only the symptoms, not the pathological cause. With the cost to society rising, the debilitating nature of the disease and the pressure put on the family ...
openaire   +1 more source