Results 121 to 130 of about 400,612 (318)
Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217
Scientific ReportsNowadays, there is an unmet need for reliable and minimally-invasive diagnosis tools capable of detecting Alzheimer’s disease at early stages. Such tools could significantly reduce the reliance on confirmatory tests that are invasive and costly, such as ...
Aleix Martí-Navia +9 more
doaj +1 more source
, 2019 Table S1. List of all antibodies used, with respective working dilutions for either WB or IHF, as well as Companies of origin and catalog number specification. (PDF 290 kb)
Di Benedetto, Giulia +8 more
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak +4 more
wiley +1 more source
The activity of amyloid beta binding alcohol dehydrogenase in Alzheimer's disease
, 2012 The mitochondria are a vibrant hub for many problems that occur in Alzheimer’s disease. The enzyme amyloid-ß binding alcohol dehydrogenase (ABAD) and Cyclophilin D (CypD) are two key mitochondrial proteins that have essential functions in Alzheimer’s ...
Allen, Zoe Eleanor
core
Alzheimer’s disease detection using artificial intelligence
, 2022 Biomedical data relevant to several diseases are generally employed to diagnose precise physiological or pathological conditions. The objective of biomedical image analysis is exact modeling by using Artificial Intelligence (AI) algorithms to diagnose ...
Subasi, Abdulhamit +2 more
core +1 more source
, 2019 Figure S2. Effects of the treatment with an anti-TNFSF10 monoclonal antibody on the expression of FoxP3, as well as the anti-inflammatory protein IL-10 in the hippocampus of 3xTg-AD mice. Immunofluorescence by confocal microscopy of hippocampi for IL-10 and FoxP3 expression and co-localization from the same animal groups as above (merge column; DAPIâ ...
Di Benedetto, Giulia +8 more
openaire +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
, 2017 Shows the authorsâ judgements for risk of bias assessment domains with supporting reasons. (DOCX 20 kb)
Abushouk, Abdelrahman +6 more
openaire +1 more source
Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke +5 more
wiley +1 more source
Alzheimer’s Disease: Theories of Causation
Alzheimer’s disease will be the epidemic of the twenty-first century (1,2). The generally accepted figures are that 5% of individuals of the age of 65 have severe dementia, and another 10% have moderate dementia, with 30% having developed dementia if ...
Bradley, Walter G
core +1 more source