Results 81 to 90 of about 5,180,843 (313)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Donepezil and Memantine for moderate-to-severe Alzheimer's disease [PDF]

, 2012
Background Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer’s disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease ...
O'Brien, John, Roy Jones (3539210), Juszczak, E, R. Brown (3682735), Gray, R, Richard Gray (2619970), Ballard, C, Burns, Alistair; id_orcid, Adams, Jessica, Knapp, M, J. Adams (7579901), Knapp, Martin, Robert Hills (3685870), Baldwin, A, P. Passmore (7608800), Dening, Tom, Griffin, M, S. Banerjee (1503751), B. Sheehan (7608761), Jones, Roy, T. Dening (7608776), Craig Ritchie (3531092), Sheehan, Bart, McShane, R, Mary Griffin (3203010), Bentham, Peter, O'Brien, John, Bart Sheehan (3836236), McShane, Rupert, Brown, R, Clive Holmes (237359), Dening, T, Hughes, Alan, Robin Jacoby (89610), Jones, R., Holmes, C, Clive Ballard (89605), Jacoby, Robin, Phillips, Patrick, Alan Hughes (178653), Sube Banerjee (4464202), D. Findlay (7608779), McKeith, I, Martin Knapp (146158), Ritchie, C. W., A. Baldwin (7608767), Ritchie, Craig, P. Phillips (5239541), Barber, R, C. Katona (6059216), David Findlay (46833), Banerjee, S, P. Bentham (7589273), Juszczak, Ed, Peter Bentham (16155026), Ashley Baldwin (14422653), Cornelius Katona (15210), Brown, Richard, J. Lindesay (7635890), McKeith, Ian, Barber, Robert, Brown, Richard; id_orcid, E. Juszczak (7589267), Burns, A, Banerjee, Sube, Macharouthu, Ajay, Edmund Juszczak (89612), Passmore, P, Jones, R, James Lindesay (7582160), Gray, Richard, Phillips, P, R. Jacoby (7589288), J. O'Brien (7608797), Robert Barber (337950), Phillips, P., A. Burns (842688), Tom Dening (3097692), R. Howard (1274091), Juszczak, Edmund, Ian McKeith (369422), Patrick Phillips (1420741), C. Holmes (7589285), Peter Passmore (254593), M. Griffin (3933326), Macharouthu, A, M. Knapp (2534038), Rupert McShane (89609), C. Ballard (7608770), Passmore, Peter, Johnson, T, R. l. Barber (7635893), Robert Howard (190740), Hills, Robert Kerrin, Findlay, David, Jacoby, R, Johnson, T., Hughes, A., Barber, R., Howard, Robert, Jessica Adams (2640001), Jones, Roy W., O'Brien, J. T., R. McShane (7608791), Howard, R, Holmes, Clive, Katona, C, Lindesay, J, I. McKeith (7608788), Ritchie, C, Adams, J., A. Macharouthu (7608794), T. Johnson (7602368), Johnson, Tony, McKeith, I. G., A. Hughes (7190519), Jones, Rob, Caroline Onions (16155023), Katona, C. L. E., R. Hills (7635896), John O'Brien (377563), Hills, Robert, Hughes, A, Lindesay, James, Hills, R, Rob Jones (3023226), Tony Johnson (1947625), Onions, Caroline, Griffin, Mary, C. Ritchie (7608806), Onions, C, Richard Brown (130157), Katona, Cornelius, Baldwin, Ashley, Sheehan, B, Adams, J, Burns, Alistair, Burns, Alistair S., Griffin, M., R. Jones (3979994), Ballard, Clive, C. Onions (7608764), Alistair Burns (3580904), Findlay, D, O'Brien, J, Bentham, P, R. Gray (7608782), Ajay Macharouthu (6553472)   +147 more
core   +1 more source

Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease

Experimental and Molecular Medicine
Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular membrane, and regulate cellular function ...
Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae   +3 more
doaj   +1 more source

Relationship between afternoon napping and cognitive function in the ageing Chinese population

General Psychiatry, 2021
Background Several studies have shown that afternoon napping promotes cognitive function in the elderly; on the other hand, some studies have shown opposite results.
Wei Li, Xia Li, Shifu Xiao, Lin Sun, Han Cai, Ning Su   +5 more
doaj   +1 more source

Additional file 4: of Older patients are still under-represented in clinical trials of Alzheimerâ s disease

, 2016
Main characteristics of trials included in the age analyses (79). (DOCX 30 kb)
Banzi, Rita, Camaioni, Paolo, Tettamanti, Mauro, Bertele’, Vittorio, Lucca, Ugo   +4 more
openaire   +1 more source

Robust automated detection of microstructural white matter degeneration in Alzheimer’s disease using machine learning classification of multicenter DTI data [PDF]

, 2013
Diffusion tensor imaging (DTI) based assessment of white matter fiber tract integrity can support the diagnosis of Alzheimer’s disease (AD). The use of DTI as a biomarker, however, depends on its applicability in a multicenter setting accounting for ...
Thomas Kirste, Stefan J. Teipel (417223), Stefan J. Teipel, Fellgiebel, Andreas, Karlheinz Hauenstein (417221), Hauenstein, K., Kilimann, I., Harald Hampel, Thomas Kirste (417222), Dyrba, M., Kirste, Thomas, Bokde, A.L.W., Kilimann, Ingo, Annahita Oswald, Pievani, M., Filippi, M., Martin Dyrba (417214), Ewers, Michael, Martin Wegrzyn, Hauenstein, Karlheinz, Ewers, M., Klöppel, Stefan, Arun L. W. Bokde (206207), Pievani, Michela, Oswald, Annahita, Michela Pievani, EDSD, [Study group], Claudia Plant, Klöppel, S., Karlheinz Hauenstein, Andreas Fellgiebel, Michael Ewers (317132), Massimo Filippi, Thomas Meindl, Arun L W Bokde, Martin Dyrba, Plant, C., Wegrzyn, Martin, Teipel, Stefan, Thomas Meindl (417219), Massimo Filippi (110054), Filippi, Massimo, Claudia Plant (417217), Bokde, Arun L. W., Wegrzyn, M., Kirste, T., Hampel, Harald, Andreas Fellgiebel (382233), Stefan Klöppel (261558), Annahita Oswald (417218), Arun L. W. Bokde, EDSD study group, Meindl, Thomas, Michael Ewers, Ingo Kilimann, EDSD Study Group (), Martin Wegrzyn (417215), Stefan Klöppel, Stefan J Teipel, Michela Pievani (417220), Hampel, H., Plant, Claudia, Harald Hampel (183230), Oswald, A., Teipel, Stefan J., Meindl, T., Teipel, S.J., Ingo Kilimann (417216), Fellgiebel, A., Dyrba, Martin   +69 more
core   +2 more sources

Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits

Scientific Reports, 2023
Differential gene expression (DGE) analysis has been widely employed to identify genes expressed differentially with respect to a trait of interest using RNA sequencing (RNA-Seq) data.
Shizhen Tang, Aron S. Buchman, Yanling Wang, Denis Avey, Jishu Xu, Shinya Tasaki, David A. Bennett, Qi Zheng, Jingjing Yang   +8 more
doaj   +1 more source

Additional file 1: of Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimerâ s disease

, 2016
Presents the results of the alternative analysis based on consideration of borderline and positive biomarker values together. (DOCX 27 kb)
Alexopoulos, Panagiotis, Werle, Lukas, Roesler, Jennifer, Thierjung, Nathalie, Gleixner, Lena, Yakushev, Igor, Laskaris, Nikolaos, Wagenpfeil, Stefan, Gourzis, Philippos, Kurz, Alexander, Perneczky, Robert   +10 more
openaire   +1 more source

Additional file 2: of Older patients are still under-represented in clinical trials of Alzheimerâ s disease

, 2016
list of excluded studies. (DOCX 129 kb)
Banzi, Rita, Camaioni, Paolo, Tettamanti, Mauro, Bertele’, Vittorio, Lucca, Ugo   +4 more
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source