Results 81 to 90 of about 400,612 (318)

G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults

Communications Biology
Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected.
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett   +10 more
doaj   +1 more source

MOESM1 of Histone post-translational modifications in frontal cortex from human donors with Alzheimerâ s disease

, 2015
Additional file 1: Table S1. Donor information.
Anderson, Kyle, Turko, Illarion
openaire   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Comparison of destabilizing activities of a well-known αβ-fibril destabilizer rifampicin with methylene blue for its usage in Alzheimer’s disease treatment [PDF]

, 2013
The aim of this experiment was to determine whether methylene blue has a destabilizing effect on αβ-fibrils or not for the usage in Alzheimer’s disease treatment.
Dursun, Merve
core  

Robust automated detection of microstructural white matter degeneration in Alzheimer’s disease using machine learning classification of multicenter DTI data

, 2013
Diffusion tensor imaging (DTI) based assessment of white matter fiber tract integrity can support the diagnosis of Alzheimer’s disease (AD). The use of DTI as a biomarker, however, depends on its applicability in a multicenter setting accounting for ...
Thomas Kirste, Stefan J. Teipel (417223), Stefan J. Teipel, Fellgiebel, Andreas, Karlheinz Hauenstein (417221), Hauenstein, K., Kilimann, I., Harald Hampel, Thomas Kirste (417222), Dyrba, M., Kirste, Thomas, Bokde, A.L.W., Kilimann, Ingo, Annahita Oswald, Pievani, M., Filippi, M., Martin Dyrba (417214), Ewers, Michael, Martin Wegrzyn, Hauenstein, Karlheinz, Ewers, M., Klöppel, Stefan, Arun L. W. Bokde (206207), Pievani, Michela, Oswald, Annahita, Michela Pievani, EDSD, [Study group], Claudia Plant, Klöppel, S., Karlheinz Hauenstein, Andreas Fellgiebel, Michael Ewers (317132), Massimo Filippi, Thomas Meindl, Arun L W Bokde, Martin Dyrba, Plant, C., Wegrzyn, Martin, Teipel, Stefan, Thomas Meindl (417219), Massimo Filippi (110054), Filippi, Massimo, Claudia Plant (417217), Bokde, Arun L. W., Wegrzyn, M., Kirste, T., Hampel, Harald, Andreas Fellgiebel (382233), Stefan Klöppel (261558), Annahita Oswald (417218), Arun L. W. Bokde, EDSD study group, Meindl, Thomas, Michael Ewers, Ingo Kilimann, EDSD Study Group (), Martin Wegrzyn (417215), Stefan Klöppel, Stefan J Teipel, Michela Pievani (417220), Hampel, H., Plant, Claudia, Harald Hampel (183230), Oswald, A., Teipel, Stefan J., Meindl, T., Teipel, S.J., Ingo Kilimann (417216), Fellgiebel, A., Dyrba, Martin   +69 more
core   +1 more source

Additional file 2: of Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimerâ s disease

, 2016
Is an acknowledgements list for ADNI publications: ADNI infrastructure and site investigators. (PDF 661 kb)
Alexopoulos, Panagiotis, Werle, Lukas, Roesler, Jennifer, Thierjung, Nathalie, Gleixner, Lena, Yakushev, Igor, Laskaris, Nikolaos, Wagenpfeil, Stefan, Gourzis, Philippos, Kurz, Alexander, Perneczky, Robert   +10 more
openaire   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Quick assessment for systematic test statistic inflation/deflation due to null model misspecifications in genome-wide environment interaction studies.

PLoS ONE, 2019
Gene-environment (GxE) interaction is one potential explanation for the missing heritability problem. A popular approach to genome-wide environment interaction studies (GWEIS) is based on regression models involving interactions between genetic variants ...
Masao Ueki, Masahiro Fujii, Gen Tamiya, for Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer’s Disease Metabolomics Consortium   +3 more
doaj   +1 more source

MOESM2 of Histone post-translational modifications in frontal cortex from human donors with Alzheimerâ s disease

, 2015
Additional file 2: Table S2. MRM transitions used for identification.
Anderson, Kyle, Illarion Turko
openaire   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source