Results 81 to 90 of about 647,233 (310)

Protein phosphatase 2A dysfunction in Alzheimer’s disease [PDF]

Frontiers in Molecular Neuroscience, 2014
Protein phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular processes, sophisticated regulatory mechanisms are ultimately responsible for ensuring isoform-specific substrate specificity.
Sontag, Jean-Marie, Sontag, Estelle
openaire   +3 more sources

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males

Nature Communications, 2023
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear.
Daniel H. Daneshvar, Evan S. Nair, Zachary H. Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Christine M. Baugh, Brett M. Martin, Joseph N. Palmisano, Jonathan D. Cherry, Victor E. Alvarez, Bertrand R. Huber, Jennifer Weuve, Christopher J. Nowinski, Robert C. Cantu, Ross D. Zafonte, Brigid Dwyer, John F. Crary, Lee E. Goldstein, Neil W. Kowall, Douglas I. Katz, Robert A. Stern, Yorghos Tripodis, Thor D. Stein, Michael D. McClean, Michael L. Alosco, Ann C. McKee, Jesse Mez   +30 more
doaj   +1 more source

Speaking with Barry Rovner, MD [PDF]

, 2009
Q: What Alzheimer’s related studies are you involved in currently at the Farber Institute for Neurosciences? Dr. Rovner: We are evaluating three exciting new disease-modifying drug treatments that may slow down the course of Alzheimer’s disease.

core   +1 more source

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease [PDF]

, 2015
Acknowledgements: Authors want to express their gratitude to Dr. P. Davies (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder (NorthWestern, Chicago, IL, USA) for the generous gift of mAbs (TG-3, Alz-50, and MC1), and (TauC-3 ...
Cárdenas-Aguayo, María C, Flores-Rodríguez, Paola, Florán-Garduño, Benjamin, Harrington, Charles R, Luna-Arias, Juan P, Luna-Muñoz, José, Mena, Raúl, Meraz-Ríos, Marco A, Ontiveros-Torres, Miguel A, Viramontes-Pintos, Amparo, Wischik, Claude M   +10 more
core   +2 more sources

MOESM1 of Plasma lipoproteome in Alzheimerâ s disease: a proof-of-concept study

, 2018
Additional file 1. Supplementary methods.
Li, Danni, Huang, Fangying, Zhao, Yingchun, Villata, Peter, Griffin, Timothy, Zhang, Lin, Li, Ling, Yu, Fang   +7 more
openaire   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults

Communications Biology
Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected.
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett   +10 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Quick assessment for systematic test statistic inflation/deflation due to null model misspecifications in genome-wide environment interaction studies.

PLoS ONE, 2019
Gene-environment (GxE) interaction is one potential explanation for the missing heritability problem. A popular approach to genome-wide environment interaction studies (GWEIS) is based on regression models involving interactions between genetic variants ...
Masao Ueki, Masahiro Fujii, Gen Tamiya, for Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer’s Disease Metabolomics Consortium   +3 more
doaj   +1 more source