Results 51 to 60 of about 5,180,843 (313)

MOESM1 of Patterns of Chinese medicine use in prescriptions for treating Alzheimerâ s disease in Taiwan

, 2016
Additional file 1. The approval Letter from Taipei City Hospital Institutional Review Board.
Shun-Ku Lin, Sui-Hing Yan, Jung-Nien Lai, Tung-Hu Tsai   +3 more
openaire   +1 more source

Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis

BMC Genomics, 2021
Background Early-onset familial Alzheimer’s disease (EOfAD) is promoted by dominant mutations, enabling the study of Alzheimer’s disease (AD) pathogenic mechanisms through generation of EOfAD-like mutations in animal models.
Yang Dong, Morgan Newman, Stephen M. Pederson, Karissa Barthelson, Nhi Hin, Michael Lardelli   +5 more
doaj   +1 more source

NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]

, 2014
There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Teeling, Jessica L., James P. Fuller, Jeffrey B. Stavenhagen, Jessica L. Teeling, Stavenhagen, Jeffrey B., Fuller, James P.   +5 more
core   +1 more source

Brain insulin signaling and cerebrovascular disease in human postmortem brain

Acta Neuropathologica Communications, 2021
Insulin is an important hormone for brain function, and alterations in insulin metabolism may be associated with neuropathology. We examined associations of molecular markers of brain insulin signaling with cerebrovascular disease.
Zoe Arvanitakis, Ana W. Capuano, Hoau-Yan Wang, Julie A. Schneider, Alifiya Kapasi, David A. Bennett, Rexford S. Ahima, Steven E. Arnold   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Communicability disruption in Alzheimer’s disease connectivity networks

, 2019
In real-world networks, information from source to destination does not only flow along the shortest path connecting them, but can flow along any alternative route.
Eufemia Lella, Tommaso Maggipinto, Angela Lombardi, Nicola Amoroso, Roberto Bellotti, Sabina Tangaro, Alzheimer’s Disease Neuroimaging Initiative   +6 more
core   +1 more source

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Molecular Neurodegeneration, 2018
Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients.
WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco   +7 more
doaj   +1 more source

Additional file 1: of Attitudes toward clinical trials across the Alzheimerâ s disease spectrum

, 2017
Appendix. (DOC 59 kb)
NuĂąo, Michelle, Gillen, Daniel, Dosanjh, Kulwant, Brook, Jenny, Elashoff, David, Ringman, John, Grill, Joshua   +6 more
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Probabilistic prediction of Alzheimer’s disease from multimodal image data with Gaussian processes [PDF]

, 2015
Alzheimer’s disease, the most common form of dementia, is an extremely serious health problem, and one that will become even more so in the coming decades as the global population ages.
Young, JM
core