Results 51 to 60 of about 238,162 (269)

Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer’s Disease

Biomedicines, 2022
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical ...
Md Riad Chowdhury, Hee Kyung Jin, Jae-sung Bae   +2 more
doaj   +1 more source

Additional file 2: of Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimerâ s disease

, 2016
Is an acknowledgements list for ADNI publications: ADNI infrastructure and site investigators. (PDF 661 kb)
Alexopoulos, Panagiotis, Werle, Lukas, Roesler, Jennifer, Thierjung, Nathalie, Gleixner, Lena, Yakushev, Igor, Laskaris, Nikolaos, Wagenpfeil, Stefan, Gourzis, Philippos, Kurz, Alexander, Perneczky, Robert   +10 more
openaire   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

MOESM2 of Histone post-translational modifications in frontal cortex from human donors with Alzheimerâ s disease

, 2015
Additional file 2: Table S2. MRM transitions used for identification.
Anderson, Kyle, Illarion Turko
openaire   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease

Experimental and Molecular Medicine
Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular membrane, and regulate cellular function ...
Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae   +3 more
doaj   +1 more source

Mitochondrial links between brain aging and Alzheimer’s disease

Translational Neurodegeneration, 2021
Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging.
Heather M. Wilkins, Russell H. Swerdlow
doaj   +1 more source

Diet moderates the effect of resting state functional connectivity on cognitive function

Scientific Reports, 2022
Past research suggests modifiable lifestyle factors impact structural and functional measures of brain health, as well as cognitive performance, but no study to date has tested the effect of diet on resting state functional connectivity (rsFC), and its ...
Alexandra M. Gaynor, Eleanna Varangis, Suhang Song, Yunglin Gazes, Diala Noofoory, Reshma S. Babukutty, Christian Habeck, Yaakov Stern, Yian Gu   +8 more
doaj   +1 more source

Additional file 4: of Older patients are still under-represented in clinical trials of Alzheimerâ s disease

, 2016
Main characteristics of trials included in the age analyses (79). (DOCX 30 kb)
Banzi, Rita, Camaioni, Paolo, Tettamanti, Mauro, Bertele’, Vittorio, Lucca, Ugo   +4 more
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source