Results 51 to 60 of about 647,233 (310)

Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lower hippocampal volume is associated with late‐life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume.
Alifiya Kapasi, Ana W. Capuano, Melissa Lamar, Sue E. Leurgans, Arnold M. Evia, David A. Bennett, Konstantinos Arfanakis, Julie A. Schneider   +7 more
doaj   +1 more source

Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]

, 2018
IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat, Brown, Jesse A, Fredericks, Carolyn A, Hua, Alice Y, Resnick, Susan M, Seeley, William W, Sturm, Virginia E, Wong, Dean F   +7 more
core   +1 more source

Additional file 2: of The neuropathological diagnosis of Alzheimerâ s disease

, 2019
Figure S2. Clinical Diagnoses of 227 Patients with a Pathologic Diagnosis of Pure AD. More than a third of pathologic AD cases on the Mayo Clinic Brain Bank from 2007 to 2016 were not expected to have AD. (PPTX 52 kb)
DeTure, Michael, Dickson, Dennis
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
Akiyama, Alharbi, Armitage, Armitage, Armitage, Balin, Barbieri, Bergdahl, Berliner, Borilova Linhartova, Borrell-Pages, Bowling, Braak, Braak, Brown, Bu, Buchanan, Burt, Cambell, Cavrini, Chiu, Chukkapalli, Chukkapalli, Chukkapalli, Cole, Corder, Corrada, Curtiss, Cutler, De Oliveira, DeFronzo, DeStefano, Desvarieux, Duarte, Epel, Farrer, Forner, Foster, Freitag-Wolf, Galbraith, Gan, Gao, Genco, Grehan, Grossi, Habib, Haffajee, Hajishengalis, Hajishengalis, Haraszthy, Hardardottir, Hardy, Harold, Harper, Hayashi, Hayden, Heiduschka, Helfand, Het, Hitt, Holt, Hu, Huang, Hunter, Hutton, Imhof, Iqbal, Itzhaki, Jagannathachary, Joiner, Kamer, Kamer, Kamer, Katz, Khovidhunkit, Klein, Kliegel, Kolovou, Kornman, Kozarov, Kubota, Lalla, Lambert, Lesne, Leszcynska, Libby, Machado, Mahley, Mahley, Mahley, Mahley, Maney, Marti, McGeer, Michalowicz, Miklossy, Miklossy, Miller, Mooradian, Moutsopoulos, Nagpal, Neto, Nicoll, Noble, Okuda, Olsen, Ono, O’Brien, Papapanou, Perls, Pitas, Pizzo, Poirier, Poling, Poole, Poole, Rivera, Riviere, Rogers, Rohn, Roses, Roses, Rowe, Saito, Saunders, Scannapieco, Schuett, Shao, Singhrao, Singhrao, Singhrao, Singhrao, Small, Smit, Socransky, Soscia, Stein, Strittmatter, Strittmatter, Sullivan, Velsko, Walsh, Walsh, Watkins, Weisgraber, Wetterau, Wilson, Young   +147 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mitochondrial links between brain aging and Alzheimer’s disease

Translational Neurodegeneration, 2021
Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging.
Heather M. Wilkins, Russell H. Swerdlow
doaj   +1 more source

Additional file 3: of The neuropathological diagnosis of Alzheimerâ s disease

, 2019
Figure S3. Pathologic Diagnoses in 626 Patients with Clinical Diagnosis of AD. The majority of clinical AD cases as observed in the Mayo Clinic Brain Bank from 2007 to 2016 were found to have co-pathologies. (PPTX 63 kb)
DeTure, Michael, Dickson, Dennis
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Astrocytic transporters in Alzheimer's disease [PDF]

, 2016
Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, including ...
Abdul, Ahmed, Alexander, Alexander, Almeida, Amara, Aroeira, Assal, Augustin, Banerjee, Bareggi, Bates, Beart, Beaugé, Beckstrøm, Bjørnsen, Blakely, Boehm-Cagan, Boehm-Cagan, Bolaños, Borden, Bouvier, Bowen, Boycott, Boyden, Brekke, Bridges, Broccardo, Brown, Burkhalter, Busch, Bussière, Butterfield, Cahoy, Carageorgiou, Casper, Chauhan, Chen, Chen, Chen, Chen, Chiang, Cirrito, Coco, Colton, Crambert, Cudkowicz, Cunnane, Dallas, Danbolt, Dawson, De Strooper, Dickey, Dienel, Dolińska, Dong, Duerson, Dunlop, Eulenburg, Figueiredo, Fontana, Fotiadis, Francis, Fu, Fuller, Gannon, Garcia-Alloza, Genda, Gottesman, Graham, Hafiane, Halestrap, Hanu, Harada, Hardie, Hardy, Harik, Harris, Hartz, Hattori, Haydon, Heneka, Hermenegildo, Hewett, Hill, Hirrlinger, Hirst, Hollingworth, Hsu, Hu, Hu, Huang, Huang, Huey, Hynd, Imfeld, Inazu, Israel, Jacob, Jankowsky, Jensen, Jeynes, Jiang, Juopperi, Kandimalla, Kaplan, Kapogiannis, Katz, Katz, Kepe, Kim, Kim, Kim, Kim, Kirischuk, Koch, Kondo, Kong, Kong, Krencik, Krencik, Kristensen, Kruh, Kulijewicz-Nawrot, Kunugi, Kurella, Köfalvi, Lam, Lee, Lee, Lee, Lent, Lewerenz, Lewerenz, Li, Li, Li, Liu-Seifert, Lombardo, Luurtsema, Malynn, Maragakis, Maragakis, Maragos, Marner, Marroni, Masliah, Masliah, Massie, McGrail, Mehta, Mercier, Mergenthaler, Merlini, Mesci, Michikawa, Middeldorp, Mirbolooki, Moechars, Mohler, Mookherjee, Mooradian, Morrissette, Mosconi, Mosconi, Mosconi, Moseley, Mota, Mueckler, Nakagawa, Niccoli, Nies, Nijland, Oddo, Ohnishi, Olabarria, Olabarria, Oliveira, Oliveira, Orr, Orre, Palmer, Palmer, Pellerin, Pellerin, Pellerin, Peng, Pierre, Pirttimaki, Polanski, Pow, Pow, Raiteri, Rambo, Ramirez, Richerson, Rodriguez-Vieitez, Rose, Rose, Rothstein, Sakae, Sato, Savolainen, Schallier, Schousboe, Schousboe, Schwab, Sevigny, Shih, Shih, Simpson, Simpson, Simpson, Sofroniew, Son, Soontornmalai, Soucek, Sultana, Suzuki, Sweadner, Tadi, Tajeddinn, Tajeddinn, Takahashi, Tanaka, Tang, Thöne-Reineke, Timmer, Tomi, Tong, Tsang, Upton, Van Dam, van Neerven, Vandenberg, Vannucci, Vemula, Verkhratsky, Verkhratsky, Verkhratsky, Verkhratsky, Verret, Vitvitsky, Vlassenko, Vogelgesang, Volterra, Volterra, White, Wildsmith, Wilkin, Williams, Winkler, Wolf, Woltjer, Wright, Wu, Yagi, Yamashita, Yang, Ye, Yernool, Yuede, Zhang, Zhou, Zlomuzica, Zumkehr   +265 more
core   +2 more sources