Results 31 to 40 of about 400,612 (318)

Additional file 2: of The neuropathological diagnosis of Alzheimerâ s disease

, 2019
Figure S2. Clinical Diagnoses of 227 Patients with a Pathologic Diagnosis of Pure AD. More than a third of pathologic AD cases on the Mayo Clinic Brain Bank from 2007 to 2016 were not expected to have AD. (PPTX 52 kb)
DeTure, Michael, Dickson, Dennis
openaire   +1 more source

Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases

Acta Neuropathologica Communications, 2022
Background This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2. Methods Data originate from 20 decedents who underwent brain autopsy followed by ex-vivo imaging and ...
Sonal Agrawal, Jose M. Farfel, Konstantinos Arfanakis, Lena Al-Harthi, Tanner Shull, Tara L. Teppen, Arnold M. Evia, Mayur B. Patel, E. Wesley Ely, Sue. E. Leurgans, David A. Bennett, Rupal Mehta, Julie A. Schneider   +12 more
doaj   +1 more source

Additional file 3: of The neuropathological diagnosis of Alzheimerâ s disease

, 2019
Figure S3. Pathologic Diagnoses in 626 Patients with Clinical Diagnosis of AD. The majority of clinical AD cases as observed in the Mayo Clinic Brain Bank from 2007 to 2016 were found to have co-pathologies. (PPTX 63 kb)
DeTure, Michael, Dickson, Dennis
openaire   +1 more source

Donepezil and Memantine for moderate-to-severe Alzheimer's disease [PDF]

, 2012
Background Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer’s disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease ...
O'Brien, John, Roy Jones (3539210), Juszczak, E, R. Brown (3682735), Gray, R, Richard Gray (2619970), Ballard, C, Burns, Alistair; id_orcid, Adams, Jessica, Knapp, M, J. Adams (7579901), Knapp, Martin, Robert Hills (3685870), Baldwin, A, P. Passmore (7608800), Dening, Tom, Griffin, M, S. Banerjee (1503751), B. Sheehan (7608761), Jones, Roy, T. Dening (7608776), Craig Ritchie (3531092), Sheehan, Bart, McShane, R, Mary Griffin (3203010), Bentham, Peter, O'Brien, John, Bart Sheehan (3836236), McShane, Rupert, Brown, R, Clive Holmes (237359), Dening, T, Hughes, Alan, Robin Jacoby (89610), Jones, R., Holmes, C, Clive Ballard (89605), Jacoby, Robin, Phillips, Patrick, Alan Hughes (178653), Sube Banerjee (4464202), D. Findlay (7608779), McKeith, I, Martin Knapp (146158), Ritchie, C. W., A. Baldwin (7608767), Ritchie, Craig, P. Phillips (5239541), Barber, R, C. Katona (6059216), David Findlay (46833), Banerjee, S, P. Bentham (7589273), Juszczak, Ed, Peter Bentham (16155026), Ashley Baldwin (14422653), Cornelius Katona (15210), Brown, Richard, J. Lindesay (7635890), McKeith, Ian, Barber, Robert, Brown, Richard; id_orcid, E. Juszczak (7589267), Burns, A, Banerjee, Sube, Macharouthu, Ajay, Edmund Juszczak (89612), Passmore, P, Jones, R, James Lindesay (7582160), Gray, Richard, Phillips, P, R. Jacoby (7589288), J. O'Brien (7608797), Robert Barber (337950), Phillips, P., A. Burns (842688), Tom Dening (3097692), R. Howard (1274091), Juszczak, Edmund, Ian McKeith (369422), Patrick Phillips (1420741), C. Holmes (7589285), Peter Passmore (254593), M. Griffin (3933326), Macharouthu, A, M. Knapp (2534038), Rupert McShane (89609), C. Ballard (7608770), Passmore, Peter, Johnson, T, R. l. Barber (7635893), Robert Howard (190740), Hills, Robert Kerrin, Findlay, David, Jacoby, R, Johnson, T., Hughes, A., Barber, R., Howard, Robert, Jessica Adams (2640001), Jones, Roy W., O'Brien, J. T., R. McShane (7608791), Howard, R, Holmes, Clive, Katona, C, Lindesay, J, I. McKeith (7608788), Ritchie, C, Adams, J., A. Macharouthu (7608794), T. Johnson (7602368), Johnson, Tony, McKeith, I. G., A. Hughes (7190519), Jones, Rob, Caroline Onions (16155023), Katona, C. L. E., R. Hills (7635896), John O'Brien (377563), Hills, Robert, Hughes, A, Lindesay, James, Hills, R, Rob Jones (3023226), Tony Johnson (1947625), Onions, Caroline, Griffin, Mary, C. Ritchie (7608806), Onions, C, Richard Brown (130157), Katona, Cornelius, Baldwin, Ashley, Sheehan, B, Adams, J, Burns, Alistair, Burns, Alistair S., Griffin, M., R. Jones (3979994), Ballard, Clive, C. Onions (7608764), Alistair Burns (3580904), Findlay, D, O'Brien, J, Bentham, P, R. Gray (7608782), Ajay Macharouthu (6553472)   +147 more
core   +1 more source

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Molecular Neurodegeneration, 2018
Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients.
WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco   +7 more
doaj   +1 more source

MOESM1 of Plasma lipoproteome in Alzheimerâ s disease: a proof-of-concept study

, 2018
Additional file 1. Supplementary methods.
Li, Danni, Huang, Fangying, Zhao, Yingchun, Villata, Peter, Griffin, Timothy, Zhang, Lin, Li, Ling, Yu, Fang   +7 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Brain insulin signaling and cerebrovascular disease in human postmortem brain

Acta Neuropathologica Communications, 2021
Insulin is an important hormone for brain function, and alterations in insulin metabolism may be associated with neuropathology. We examined associations of molecular markers of brain insulin signaling with cerebrovascular disease.
Zoe Arvanitakis, Ana W. Capuano, Hoau-Yan Wang, Julie A. Schneider, Alifiya Kapasi, David A. Bennett, Rexford S. Ahima, Steven E. Arnold   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lower hippocampal volume is associated with late‐life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume.
Alifiya Kapasi, Ana W. Capuano, Melissa Lamar, Sue E. Leurgans, Arnold M. Evia, David A. Bennett, Konstantinos Arfanakis, Julie A. Schneider   +7 more
doaj   +1 more source