Results 31 to 40 of about 647,233 (310)

Communication Bridge™-2 (CB2): an NIH Stage 2 randomized control trial of a speech-language intervention for communication impairments in individuals with mild to moderate primary progressive aphasia

Trials, 2022
Background Primary progressive aphasia (PPA) is a clinical dementia syndrome. Impairments in language (speaking, reading, writing, and understanding) are the primary and persistent symptoms.
Angela C. Roberts, Alfred W. Rademaker, Elizabeth Ann Salley, Aimee Mooney, Darby Morhardt, Melanie Fried-Oken, Sandra Weintraub, Marsel Mesulam, Emily Rogalski   +8 more
doaj   +1 more source

Inverse association between cancer and Alzheimer’s disease: results from the Framingham Heart Study [PDF]

, 2012
Objectives: To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer’s disease and to estimate the risk of incident cancer among participants with and without Alzheimer’s disease.
Au, Rhoda, Beiser, Alexa, Driver, Jane A, Kiel, Douglas P, Kreger, Bernard E, Kurth, Tobias, Lu, Kun Ping, Seshadri, Sudha, Splansky, Greta Lee, Wolf, Phillip A   +9 more
core   +1 more source

509 Understanding community engagement with research through a curated medical record-based database: A cross-sectional, single site study

Journal of Clinical and Translational Science
Objectives/Goals: Since clinical trial participation is a key translational research initiative, the objectiveis to characterize research participants within a health system using electronic health record (EHR) data and evaluate how community-level ...
Chuan Ching Tsai, Leping Fang, David Sedillo, John Gibbons, Jamie B Plenge, Raj Shah   +5 more
doaj   +1 more source

A review on medicinal properties of saffron toward major diseases [PDF]

, 2016
The stigma of Crocus sativus, known as saffron, is one of the most expensive spices in the world. The bioactive components in saffron, picrocrocin, crocin, and safranal, have demonstrated a wide range of uses and capabilities in the medical field.
Abd Razak, Saiful Izwan, Abdul Kadir, Mohammed Rafiq, Foong, Choi Yee, Hamzah, Mohd Syahir Anwar, Mat Nayan, Nadirul Hasraf   +4 more
core   +2 more sources

Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase

Experimental and Molecular Medicine, 2020
Age-related neurodegenerative diseases: role of enzyme crucial to membrane function Targeting a critical enzyme involved in the metabolism of cellular membrane molecules could help treat age-related neurodegenerative diseases.
Min Hee Park, Hee Kyung Jin, Jae-sung Bae   +2 more
doaj   +1 more source

Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases

Acta Neuropathologica Communications, 2022
Background This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2. Methods Data originate from 20 decedents who underwent brain autopsy followed by ex-vivo imaging and ...
Sonal Agrawal, Jose M. Farfel, Konstantinos Arfanakis, Lena Al-Harthi, Tanner Shull, Tara L. Teppen, Arnold M. Evia, Mayur B. Patel, E. Wesley Ely, Sue. E. Leurgans, David A. Bennett, Rupal Mehta, Julie A. Schneider   +12 more
doaj   +1 more source

Escala de Avaliação da Doença de Alzheimer – Subescala cognitiva (ADAS-Cog): Dados normativo para a população portuguesa [PDF]

, 2017
Introduction: The Alzheimer’s Disease Assessment Scale – Cognitive Subscale is a brief battery developed to assess cognitive functioning in Alzheimer’s disease that encompasses the core characteristics of cognitive decline (e.g. memory, language, praxis, 
Almeida, Jorge, Duro, Diana, Freitas, Sandra, Guerreiro, Manuela, Nogueira, Joana, Santana, Isabel, Tábuas-Pereira, Miguel   +6 more
core   +2 more sources

Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice

Journal of Neuroinflammation, 2018
Background Alzheimer’s disease is widely described since the discovery of histopathological lesions in Mrs. Auguste Deter in 1906. However to date, there is no effective treatment to deal with the many cellular and molecular alterations.
J. Vérité, T. Janet, D. Chassaing, B. Fauconneau, H. Rabeony, G. Page   +5 more
doaj   +1 more source

Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis

BMC Genomics, 2021
Background Early-onset familial Alzheimer’s disease (EOfAD) is promoted by dominant mutations, enabling the study of Alzheimer’s disease (AD) pathogenic mechanisms through generation of EOfAD-like mutations in animal models.
Yang Dong, Morgan Newman, Stephen M. Pederson, Karissa Barthelson, Nhi Hin, Michael Lardelli   +5 more
doaj   +1 more source

A REVIEW OF BIOCHEMICAL MARKERS FOR EARLY DIAGNOSIS OF ALZHEIMER’S DISEASE [PDF]

American Journal of Neuroscience, 2012
Alzheimer’s disease, the most prevalent type of dementia, affects the life of elderly, to such extent that it impairs the ability to perform routine functions as well. The impairment of normal functions not only affects the patients but the family members as well.
openaire   +1 more source