Results 11 to 20 of about 5,180,843 (313)

Dissecting the human leptomeninges at single-cell resolution

Nature Communications, 2023
Emerging evidence shows that the meninges conduct essential immune surveillance and immune defense at the brain border, and the dysfunction of meningeal immunity contributes to aging and neurodegeneration.
Nicola A. Kearns, Artemis Iatrou, Daniel J. Flood, Sashini De Tissera, Zachary M. Mullaney, Jishu Xu, Chris Gaiteri, David A. Bennett, Yanling Wang   +8 more
doaj   +1 more source

Explainable deep learning approach for extracting cognitive features from hand-drawn images of intersecting pentagons

npj Digital Medicine, 2023
Hand drawing, which requires multiple neural systems for planning and controlling sequential movements, is a useful cognitive test for older adults.
Shinya Tasaki, Namhee Kim, Tim Truty, Ada Zhang, Aron S. Buchman, Melissa Lamar, David A. Bennett   +6 more
doaj   +1 more source

The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

Acta Neuropathologica Communications, 2021
Lewy bodies (LBs) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older persons and associated with cognitive impairment.
Sonal Agrawal, Lei Yu, Sukriti Nag, Konstantinos Arfanakis, Lisa L. Barnes, David A. Bennett, Julie A. Schneider   +6 more
doaj   +1 more source

Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks

Nature Communications, 2022
Protein changes in a brain with Alzheimer’s are not often accompanied by transcriptional differences. Here, using a deep neural network that predicts protein abundance from mRNA expression, the authors track the early protein changes in Alzheimer’s ...
Shinya Tasaki, Jishu Xu, Denis R. Avey, Lynnaun Johnson, Vladislav A. Petyuk, Robert J. Dawe, David A. Bennett, Yanling Wang, Chris Gaiteri   +8 more
doaj   +1 more source

Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer’s Disease [PDF]

, 2020
This is the final version. Available on open access from Springer Nature via the DOI in this recordBACKGROUND: There is a clear need for simple and effective tests to identify individuals who are most likely to develop Alzheimer’s Disease (AD) both for ...
Davidson, G, Oshota, O, Daunt, P, Hardy, J, Creese, B, Ballard, CG, Gibson, AM, Pither, RJ   +7 more
core   +1 more source

Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study

Brain Sciences, 2021
The aim of the study was to examine potential cognitive, mood (depression and anxiety) and behavioral changes that may be related to the quarantine and the lockdown applied during the COVID-19 pandemic in Greek older adults with mild cognitive impairment
Marianna Tsatali, Despina Moraitou, Eleni Poptsi, Eleni Sia, Christina Agogiatou, Moses Gialaouzidis, Irene-Maria Tabakis, Konstantina Avdikou, Evaggelia Bakoglidou, Georgia Batsila, Dimitrios Bekiaridis-Moschou, Ourania Chatziroumpi, Alexandra Diamantidou, Andromachi Gavra, Eleni Kouroundi, Despina Liapi, Nefeli Markou, Fani Ouzouni, Chrysa Papasozomenou, Aikaterini Soumpourou, Magdalini Tsolaki   +20 more
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Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome

Alzheimer’s Research & Therapy, 2022
Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) and plasma from ...
Eric B. Dammer, Lingyan Ping, Duc M. Duong, Erica S. Modeste, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Erik C. B. Johnson   +7 more
doaj   +1 more source

Cortical proteins may provide motor resilience in older adults

Scientific Reports, 2021
Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that ...
Aron S. Buchman, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Shinya Tasaki, Chris Gaiteri, Robert S. Wilson, Francine Grodstein, Julie A. Schneider, Hans-Ulrich Klein, Philip L. De Jager, David A. Bennett   +11 more
doaj   +1 more source

A Longitudinal Study of Acculturation in Context and Cardiovascular Health and Their Effects on Cognition Among Older Latino Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background We previously outlined the importance of considering acculturation within the context of older Latino adults' lived experience (ie, acculturation in context) to better capture contributors to cognitive aging.
Melissa Lamar, Mayra L. Estrella, Ana W. Capuano, Sue Leurgans, Debra A. Fleischman, Lisa L. Barnes, Brittney S. Lange‐Maia, David A. Bennett, David X. Marquez   +8 more
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Differential vulnerability of the dentate gyrus to tauopathies in dementias

Acta Neuropathologica Communications, 2023
The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer’s type due to Alzheimer’s disease (DAT-AD), but less is known about the susceptibility ...
Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E. Flanagan, Rudolph Castellani, Eileen H. Bigio, M. Marsel Mesulam, Changiz Geula, Tamar Gefen   +14 more
doaj   +1 more source