Results 11 to 20 of about 400,612 (318)

Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer’s Disease [PDF]

, 2020
This is the final version. Available on open access from Springer Nature via the DOI in this recordBACKGROUND: There is a clear need for simple and effective tests to identify individuals who are most likely to develop Alzheimer’s Disease (AD) both for ...
Davidson, G, Oshota, O, Daunt, P, Hardy, J, Creese, B, Ballard, CG, Gibson, AM, Pither, RJ   +7 more
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The Clinical Use of Alzheimer’s Disease Biomarkers in Patients with Mild Cognitive Impairment: A European Alzheimer’s Disease Consortium Survey

, 2022
BACKGROUND: Recent advances occurred in the field of Alzheimer’s disease (AD) biomarkers and the introduction of a research framework grounded on a biomarker-based definition of AD might have fostered an increased clinical use of AD biomarkers.
Assal, Frédéric, Frank Jessen, Gilles Allali, Frisoni, Giovanni, Giovanni B. Frisoni, Jessen, F., European Alzheimer’s Disease Consortium (EADC), Caprioglio, C., Garibotto, V., Frölich, Lutz, Allali, G., Valentina Garibotto, Frisoni, Giovanni B., Altomare, Daniele, Camilla Caprioglio, Frédéric Assal, Frölich, L., Assal, F., Garibotto, Valentina, Daniele Altomare, Jessen, Frank, null null, Frisoni, G.B., Altomare, D., Allali, Gilles, Lutz Frölich, Caprioglio, Camilla   +26 more
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Amyloid and tau in the brain in sporadic Alzheimer’s disease: defining the chicken and the egg [PDF]

, 2014
In the October 2013 issue of Acta Neuropathologica there were three very interesting articles on: Amyloid or tau: the chicken or the egg? In the first article, David Mann and John Hardy argued that the deposition of aggregated amyloid β (Aβ) protein in ...
Cheryl A. Hawkes, Roy O. Weller, Roxana O. Carare, Hawkes, Cheryl A., Carare, Roxana O., Weller, Roy O.   +5 more
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Amyloid-beta peptide, oxidative stress and inflammation in Alzheimer’s disease: Potential neuroprotective effects of omega-3 polyunsaturated fatty acids [PDF]

, 2010
Alzheimer’s disease is the most common form of dementia in the elderly and is a progressive neurodegenerative disorder characterised by a decline in cognitive function and also profound alterations in mood and behaviour. The pathology of the disease is
S. C. Dyall, Dyall, S. C.; id_orcid, Dyall, Simon   +2 more
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Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards

Acta Neuropathologica Communications, 2019
Age is the most robust risk factor for Alzheimer’s dementia, however there is little data on the relation of age to Alzheimer’s disease (AD) and other common neuropathologies that contribute to Alzheimer’s dementia.
Jose M. Farfel, Lei Yu, Patricia A. Boyle, Sue Leurgans, Raj C. Shah, Julie A. Schneider, David A. Bennett   +6 more
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Nuclear dynamics and stress responses in Alzheimer’s disease

Molecular Neurodegeneration, 2021
In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis.
Artemis Iatrou, Eric M. Clark, Yanling Wang   +2 more
doaj   +1 more source

Exercise, cognition and Alzheimer’s disease: More is not necessarily better [PDF]

, 2005
Regional hypoperfusion, associated with a reduction in cerebral metabolism, is a hallmark of Alzheimer’s disease (AD) and contributes to cognitive decline. Cerebral perfusion and hence cognition can be enhanced by exercise.
Swaab, D.F., Scherder, E.J.A., Swaab, D, Luiten, P, Scherder, Erik,, Scherder, Erik, Eggermont, L, Swaab, Dick,, Eggermont, Laura, Luiten, P.G.M., Eggermont, L.H.P., Eggermont, Laura,, Scherder, E, Swaab, Dick, Luiten, Paul,, Luiten, Paul   +15 more
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Accelerated atrophy in dopaminergic targets and medial temporo-parietal regions precedes the onset of delusions in patients with Alzheimer’s disease [PDF]

, 2022
Additional information: *Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu).
Valera-Bermejo, JM, Manca, R., Venneri, A, Manca, R, Valera-Bermejo, J.M., Venneri, A.   +5 more
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A REVIEW OF BIOCHEMICAL MARKERS FOR EARLY DIAGNOSIS OF ALZHEIMER’S DISEASE [PDF]

American Journal of Neuroscience, 2012
Alzheimer’s disease, the most prevalent type of dementia, affects the life of elderly, to such extent that it impairs the ability to perform routine functions as well. The impairment of normal functions not only affects the patients but the family members as well.
openaire   +1 more source

Associations between Neuropsychiatric Symptoms and Alzheimer’s Disease Biomarkers in People with Mild Cognitive Impairment [PDF]

, 2023
Data Availability Statement: All ADNI data are made publicly available upon request.Background: Neuropsychiatric symptoms (NPS) are associated with faster decline in mild cognitive impairment (MCI).
Arenare, G, Venneri, A, Caffarra, P, Manca, R   +3 more
core   +1 more source