Differential vulnerability of the dentate gyrus to tauopathies in dementias
Acta Neuropathologica Communications, 2023 The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer’s type due to Alzheimer’s disease (DAT-AD), but less is known about the susceptibility ...
Allegra Kawles +14 more
doaj +1 more source
Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly a longitudinal study [PDF]
, 2018 Recent evidence suggests that Obstructive Sleep Apnea (OSA) may be a risk factor for developing Mild Cognitive Impairment and Alzheimer’s disease.
Bubu, Omonigho M. +3 more
core +2 more sources
Assessment of Screening Approach in Early and Differential Alzheimer’s Disease Diagnosis
Antioxidants, 2021 Background: Alzheimer’s disease (AD) is the leading cause of dementia in the elderly population. Currently, diagnosis is based on invasive and expensive techniques, so there is a growing need to look for other possible tests, as well as carry out ...
Laura Ferré-González +5 more
doaj +1 more source
Multimodal MRI-based Imputation of the Aβ+ in Early Mild Cognitive Impairment. [PDF]
, 2014 ObjectiveTo identify brain atrophy from structural-MRI and cerebral blood flow(CBF) patterns from arterial spin labeling perfusion-MRI that are best predictors of the Aβ-burden, measured as composite 18F-AV45-PET uptake, in individuals with early mild ...
Joshi, Sarang +3 more
core +1 more source
Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards
Acta Neuropathologica Communications, 2019 Age is the most robust risk factor for Alzheimer’s dementia, however there is little data on the relation of age to Alzheimer’s disease (AD) and other common neuropathologies that contribute to Alzheimer’s dementia.
Jose M. Farfel +6 more
doaj +1 more source
Nuclear dynamics and stress responses in Alzheimer’s disease
Molecular Neurodegeneration, 2021 In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis.
Artemis Iatrou +2 more
doaj +1 more source
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]
, 2019 Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P +9 more
core +3 more sources
The Assessment of Behavioural Decline in Adults with Down's Syndrome [PDF]
, 2007 The present study examines two methods of using the Vineland Adaptive Behaviour Scales as a measure of behavioural change in people with Down syndrome who are at risk of developing Alzheimer’s disease.
Harte, Cyan +4 more
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Level of awareness of alzheimer’s disease among elderly people in Denpasar, Bali
Intisari Sains Medis, 2020 Background: Alzheimer’s disease (AD) is a chronic, irreversible, progressive, neurodegenerative that slowly impair memory and thinking skills especially in elderly people. This study aims to determine the level of awareness of AD among elderly people in Denpasar, Bali.Methods: A descriptive cross-sectional study was conducted by using selfâ ...
Sabrina Annamma Philip +2 more
openaire +2 more sources
Targeting neuroinflammation in Alzheimer’s disease [PDF]
, 2016 Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA +3 more
core +1 more source