Results 101 to 110 of about 211,053 (311)

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease

, 2021
Background Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies. During disease progression, abnormally phosphorylated forms of tau aggregate and accumulate into neurofibrillary tangles, leading to synapse loss, neuroinflammation,
Sun, Xiao-ying, Dong, Quan-Xiu, Liu,Rui-tian, Rui-tian Liu, Zhu,Jie, Yu, Xiao-lin, Ya-ru Huang, Xiao-lin Yu, Jie Zhu, Hou, Sheng-jie, Huang,Ya-ru, Li, Ling-jie, Huang, Ya-ru, Yu,Xiao-lin, Xiao-ying Sun, Liu, Rui-tian, Ling-jie Li, Li,Ling-jie, Dong,Quan-Xiu, Sheng-jie Hou, Sun,Xiao-ying, Quan-Xiu Dong, Hou,Sheng-jie, Zhu, Jie   +23 more
core   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Structural cortical network reorganization associated with early conversion to multiple sclerosis

Scientific Reports, 2018
Brain structural covariance networks (SCNs) based on pairwise statistical associations of cortical thickness data across brain areas reflect underlying physical and functional connections between them.
C. Tur, A. Eshaghi, D. R. Altmann, T. M. Jenkins, F. Prados, F. Grussu, T. Charalambous, A. Schmidt, S. Ourselin, J. D. Clayden, C. A. M. G. Wheeler-Kingshott, A. J. Thompson, O. Ciccarelli, A. T. Toosy   +13 more
doaj   +1 more source

Intra-amniotic LPS causes acute neuroinflammation in preterm rhesus macaques [PDF]

, 2016
BackgroundChorioamnionitis is associated with an increased risk of brain injury in preterm neonates. Inflammatory changes in brain could underlie this injury.
Claire A. Chougnet, Miller, Lisa A., Paranthaman S. Kannan, Steve C. Danzer, Alan H. Jobe, Jobe, Alan H., Augusto F. Schmidt, Kannan, Paranthaman S, Chougnet, Claire A, Danzer, Steve C., Danzer, Steve C, Schmidt, Augusto F, Lisa A. Miller, Kannan, Paranthaman S., Miller, Lisa A, Kallapur, Suhas G, Chougnet, Claire A., Kallapur, Suhas G., Jobe, Alan H, Suhas G. Kallapur, Schmidt, Augusto F.   +20 more
core   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Microglia-associated progression of multiple sclerosis: target identification and therapeutic engagement in human in vitro models

Experimental and Molecular Medicine
Chronic progression of multiple sclerosis (MS) is likely to develop on the basis of a highly complex interaction of different mechanisms, which are probably already present at disease onset.
Alica Blenkle, Anastasia Geladaris, Martin S. Weber   +2 more
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia

The blood-brain barrier (BBB) is a critical interface that maintains the central nervous system homeostasis by controlling the exchange of substances between the blood and the brain.
Wang, Yu, Qiu, Linhui, Huang, Xiaowen, Hoo, Ruby Lai Chong, Fang, Cheng, Xu, Aimin, Chang, Junlei, Wei, Pengju, Yu, Min, Yang, Shilun   +9 more
core   +1 more source

Efeitos da atividade física voluntária sobre a neuroinflamação induzida por LPS [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2015.A inflamação é uma resposta biológica que ocorre em tecidos que sofreram algum tipo de lesão ou ...
Bavaresco, Anelise
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