Results 121 to 130 of about 211,053 (311)

Single-centre, prospective cohort to predict optimal individualised treatment response in multiple sclerosis (POINT-MS): a cohort profile

BMJ Open
Purpose Multiple sclerosis (MS) is a chronic neurological condition that affects approximately 150 000 people in the UK and presents a significant healthcare burden, including the high costs of disease-modifying treatments (DMTs). DMTs have substantially
, Baris Kanber, Alan J Thompson, Jeremy Chataway, Frederik Barkhof, Bhavana Solanky, Marios Yiannakas, Olga Ciccarelli, Heather Wilson, Yael Hacohen, Sarah Wright, Karen Chung, Arman Eshaghi, Le Zhang, Declan Chard, Jonathan Stutters, Ferran Prados Carrasco, Claudia Angela Gandini Wheeler-Kingshott, Floriana De Angelis, Charmaine Yam, Zhaleh Khaleeli, Marcello Moccia, Anuriti Aojula, Samih Fourali, Ahmed Toosy, Josephine Swanton, Alessia Bianchi, Wallace Brownlee, Siobhan Leary, Sarmad Al-Araji, Olivia Goodkin, Anna He, Sara Collorone, Valeria Pozzilli, Suraya Mohamud, Ronja Christensen, Alessandro Cruciani, Weaam Hamed, Ahmed Hammam, Davide Maccarrone, Riccardo Nistri, Anestis Passalis, Eirini Samdanidou, Joy Song, Jed Wingrove, Dimitrios Champas, Mohammad Kurd, Elena Panella, Fatima Pansari, Alyssa Toorop, Anand Trip, Chloe Parker, Michaela Stuart, Hanne Haagenrud   +53 more
doaj   +1 more source

Neuroinflammation in Alzheimer’s disease

, 2015
Fengjin Zhang,1,2 Linlan Jiang11Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou City, People’s Republic of China; 2School of Bioscience and Bioengineering, South China University of Technology, Guangzhou City ...
Zhang FJ, Jiang LL
core  

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Unsaponifiable and phenolic fractions from virgin olive oil prevent neuroinflammation skewing microglia polarization toward M2 phenotype

, 2019
Inhibiting M1 microglia phenotype while stimulating M2 microglia phenotype has been suggested as potential therapeutic approach for the treatment of neuroinflammation-related diseases.
Naranjo, María C., Claro Cala, Carmen María, Millán Linares, María del Carmen, Lemus Conejo, Ana, Toscano Sánchez, María del Rocío, Montserrat de la Paz, Sergio   +5 more
core   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

Neuroinflammation [PDF]

Neuroscience Bulletin, 2015
openaire   +3 more sources

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

Scientific Reports, 2017
Parkinson’s disease (PD) is associated with increased iron levels in the substantia nigra (SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regions and improve PD symptomology ...
Antonio Martin-Bastida, Roberta J. Ward, Rexford Newbould, Paola Piccini, David Sharp, Christina Kabba, Maneesh C. Patel, Michael Spino, John Connelly, Fernando Tricta, Robert R. Crichton, David T. Dexter   +11 more
doaj   +1 more source

Inflammation leads to distinct populations of extracellular vesicles from microglia

Journal of Neuroinflammation, 2018
Background Activated microglia play an essential role in inflammatory responses elicited in the central nervous system (CNS). Microglia-derived extracellular vesicles (EVs) are suggested to be involved in propagation of inflammatory signals and in the ...
Yiyi Yang, Antonio Boza-Serrano, Christopher J. R. Dunning, Bettina Hjelm Clausen, Kate Lykke Lambertsen, Tomas Deierborg   +5 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source