Results 1 to 10 of about 2,707,794 (312)

Bayesian modeling of item heterogeneity in dichotomous recognition memory data and prospects for computerized adaptive testing

Scientific Reports, 2022
Most current models of recognition memory fail to separately model item and person heterogeneity which makes it difficult to assess ability at the latent construct level and prevents the administration of adaptive tests.
Jeremie Güsten, David Berron, Emrah Düzel, Gabriel Ziegler   +3 more
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Caudo‐rostral brain spreading of α‐synuclein through vagal connections

EMBO Molecular Medicine, 2013
α‐Synuclein accumulation and pathology in Parkinson's disease typically display a caudo‐rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages.
Ayse Ulusoy, Raffaella Rusconi, Blanca I. Pérez‐Revuelta, Ruth E. Musgrove, Michael Helwig, Bettina Winzen‐Reichert, Donato A. Di Monte   +6 more
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TALKING TIME: A pilot randomized controlled trial investigating social support for informal caregivers via the telephone

BMC Health Services Research, 2020
Background Caring for people with dementia at home requires considerable time, organization and commitment. Therefore, informal caregivers of people with dementia are often overburdened. This study examined the effects of the telephone-based Talking Time
Martin Nikolaus Dichter, Bernd Albers, Diana Trutschel, Armin Michael Ströbel, Swantje Seismann-Petersen, Katharina Wermke, Margareta Halek, Martin Berwig   +7 more
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Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

Nature Communications, 2023
GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk.
Pascale Baden, Maria Jose Perez, Hariam Raji, Federico Bertoli, Stefanie Kalb, María Illescas, Fokion Spanos, Claudio Giuliano, Alessandra Maria Calogero, Marvin Oldrati, Hannah Hebestreit, Graziella Cappelletti, Kathrin Brockmann, Thomas Gasser, Anthony H. V. Schapira, Cristina Ugalde, Michela Deleidi   +16 more
doaj   +1 more source

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Molecular Neurodegeneration, 2020
Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism ...
Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, Ram Reddy Chandupatla, Sabrina Hübschmann, Stephan Irsen, Sandra Bicher, Christoph Klatt, Eva-Maria Mandelkow, Eckhard Mandelkow   +9 more
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Exploring the ATN classification system using brain morphology

Alzheimer’s Research & Therapy, 2023
Background The NIA-AA proposed amyloid-tau-neurodegeneration (ATN) as a classification system for AD biomarkers. The amyloid cascade hypothesis (ACH) implies a sequence across ATN groups that patients might undergo during transition from healthy towards ...
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Göerß, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Düzel, Gabriel Ziegler, for the Alzheimer’s Disease Neuroimaging Initiative   +42 more
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Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine.
Martin Dyrba, Moritz Hanzig, Slawek Altenstein, Sebastian Bader, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Daniel Cantré, Peter Dechent, Laura Dobisch, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, John-Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Deniz B. Keles, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Björn H. Schott, Annika Spottke, Eike J. Spruth, Marc-André Weber, Birgit Ertl-Wagner, Michael Wagner, Jens Wiltfang, Frank Jessen, Stefan J. Teipel, for the ADNI, AIBL, DELCODE study groups   +40 more
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The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors

Alzheimer’s Research & Therapy
Background With the availability of first disease-modifying treatments, evidence on costs across the entire Alzheimer's Continuum, especially for early disease stages, becomes increasingly important to inform healthcare planning, resource allocation, and
Eva Gläser, Ingo Kilimann, Moritz Platen, Wolfgang Hoffmann, Frederic Brosseron, Katharina Buerger, Marie Coenjaerts, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Ingo Frommann, Maria Gemenetzi, Wenzel Glanz, Julian Hellmann-Regen, Enise I. Incesoy, Daniel Janowitz, Frank Jessen, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Michael Wagner, Bernhard Michalowsky   +25 more
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Anti-aggregant tau mutant promotes neurogenesis

Molecular Neurodegeneration, 2017
Background The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss ...
Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow   +4 more
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Dysfunction of the episodic memory network in the Alzheimer’s disease cascade

Nature Communications
Alzheimer’s disease (AD) is a major cause of dementia and cognitive decline. Here, we assessed how episodic memory (EM) network dysfunction, a hallmark of AD, is related to the longitudinal progression of AD biomarkers, neurodegeneration and cognition ...
René Lattmann, Niklas Vockert, Jose Bernal, Judith Wesenberg, Yanin Suksangkharn, Renat Yakupov, Hartmut Schütze, Wenzel Glanz, Enise Incesoy, Michaela Butryn, Falk Lüsebrink, Matthias Schmid, Melina Stark, Luca Kleineidam, Annika Spottke, Marie Coenjaerts, Frederic Brosseron, Klaus Fliessbach, Anja Schneider, Peter Dechent, Klaus Scheffler, Stefan Hetzer, Alfredo Ramirez, Christoph Laske, Sebastian Sodenkamp, Slawek Altenstein, Luisa-Sophie Schneider, Daria Gref, Eike Jakob Spruth, Andrea Lohse, Björn H. Schott, Jens Wiltfang, Ingo Kilimann, Doreen Goerss, Ayda Rostamzadeh, Josef Priller, Oliver Peters, Julian Hellmann-Regen, Stefan Teipel, Michael Wagner, Frank Jessen, Anne Maass, Gabriel Ziegler, Emrah Düzel   +43 more
doaj   +1 more source